Results 141 to 150 of about 288,899 (312)

Damage-induced signalling mechanisms in the neonatal rat cochlea.

, 2007
Sound overstimulation and exposure to ototoxic drugs damage cochlear hair cells (HCs) and cause their death. The surrounding support cells maintain an epithelial barrier and the appropriate physiological environment for surviving HCs during pathological ...
Lahne, M.
core  

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

The role of the large conductance Ca2+-activated K+ channel in adenosine receptor-mediated cytoprotection

, 2009
The rat embryonic cardiomyoblast-derived H9c2 cell line is increasingly used for studies into cardioprotection, as these cells display similar properties to primary cardiomyocytes.
Fretwell, Laurice V, Fretwell, LV
core  

Lethal activity of FADD death domain in renal tubular epithelial cells

, 2006
Fas-associated death domain (FADD) is an adaptor protein that is required for the transmission of the death signal from lethal receptors of the tumor necrosis factor superfamily. FADD contains a death domain (DD) and a death effector domain (DED).
Justo, P., Egido, J., Sanz, A.B., Lorz, C., Ortiz, A.   +4 more
core   +1 more source

Five‐Year Disease Progression in Synuclein Seeding Positive Sporadic Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To provide a comprehensive description of disease progression in synuclein seeding assay (SAA) positive sporadic Parkinson Disease participants, using Neuronal Synuclein Disease integrated biological and functional impairment staging framework.
Paulina Gonzalez‐Latapi, Caroline Gochanour, Seung Ho Choi, Hyunkeun Cho, Chelsea Caspell‐Garcia, Christopher Coffey, Michael Brumm, David‐Erick Lafontant, Yuge Xiao, Thomas Tropea, John Seibyl, Caroline Tanner, Charles S. Venuto, Karl Kieburtz, Lana M. Chahine, Kathleen L. Poston, Andrew Siderowf, Kenneth Marek, Tanya Simuni, The Parkinson's Progression Markers Initiative   +19 more
wiley   +1 more source

Death Domain Interactions in Death Receptor Signaling

Journal of Biological Sciences, 2004
Laura M. Bender ., Andrew Thorburn .
openaire   +1 more source

Death receptors : extrinsic pathway of apoptosis

, 2012
Apoptoza jest to ściśle regulowany, naturalny proces zaprogramowanej śmierci komórek w organizmie wielokomórkowym. Dzięki niemu z organizmu usuwane są zużyte lub uszkodzone komórki.
Lonc, G., Pedrycz, A., Tomasiak, M., Siermontowski, P.   +3 more
core  

Origin and evolution of TRIM proteins: new insights from the complete TRIM repertoire of zebrafish and pufferfish

, 2011
Tripartite motif proteins (TRIM) constitute a large family of proteins containing a RING-Bbox-Coiled Coil motif followed by different C-terminal domains. Involved in ubiquitination, TRIM proteins participate in many cellular processes including antiviral
Pierre Pontarotti, Pnontarotti, P., Lieke M van der Aa, van der Aa Lieke M., Benmansour, Abdenour, Abdenour Benmansour, Jouneau Luc, Benmansour, A., Pontarotti Pierre, Boudinot Pierre, Van Der Aa, Lieke M, Levraud, Jean-Pierre, Birolat, V., Levraud, L. P., Boudinot, Pierre, Du Pasquier Louis, Jouneau, Luc, Louis Du Pasquier, Benmansour Abdenour, Valérie Briolat, Jean-Pierre Levraud, Pasquier, L., du, Briolat Valérie, Aa, L.M., van der, Pontarotti, P., du Pasquier, L., Van der aa, Lieke, Jouneau, L., Levraud, J.P., Pontarotti, Pierre, van der Aa, L.M., Du Pasquier, Louis, Boudinot, P., Briolat, Valérie, Luc Jouneau, Lieke M. van der Aa, Levraud Jean-Pierre, Boudinot, R., Pierre Boudinot, van der Aa, L. M.   +39 more
core   +2 more sources

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

A new inhibitor of apoptosis from vaccinia virus and eukaryotes.

, 2007
A new apoptosis inhibitor is described from vaccinia virus, camelpox virus, and eukaryotic cells. The inhibitor is a hydrophobic, multiple transmembrane protein that is resident in the Golgi and is named GAAP (Golgi anti-apoptotic protein).
Hollinshead, M, Smith, GL, van Kuppeveld, FJM, van Kuppeveld Frank J. M, Lu, X., Smith, G.L., Xin Lu, Gubser, C, Smith Geoffrey L, Bergamaschi, D., Bergamaschi Daniele, Hollinshead Michael, Caroline Gubser, Hollinshead, M., van Kuppeveld, FJ, Bergamaschi, D, Kuppeveld, F.J.M. van, Gubser Caroline, Geoffrey L Smith, Gubser, C., Frank J M van Kuppeveld, Michael Hollinshead, Lu Xin, Daniele Bergamaschi, Lu, Xin, Lu, X   +25 more
core   +2 more sources