Results 231 to 240 of about 294,900 (263)

Soluble Extracellular Domain of Death Receptor 5 Inhibits TRAIL-Induced Apoptosis by Disrupting Receptor–Receptor Interactions

Journal of Molecular Biology, 2017
Dysregulation of tumor necrosis factor (TNF) receptor signaling is a key feature of various inflammatory disorders. Current treatments for TNF-related diseases function either by sequestering ligand or blocking ligand-receptor interactions, which can cause dangerous side effects by inhibiting the receptors that are not involved in the disease condition.
Nagamani, Vunnam, Chih Hung, Lo, Benjamin D, Grant, David D, Thomas, Jonathan N, Sachs   +4 more
openaire   +2 more sources

Heterologous Production of Death Ligands’ and Death Receptors’ Extracellular Domains: Structural Features and Efficient Systems

Protein & Peptide Letters, 2012
The extracellular domains of death ligands and those of death receptors are closely related to many serious human diseases through the initiation of apoptosis. Recombinant production of the extracellular domains has been investigated due to demand for a large amount of purified samples, which are a prerequisite for their biochemical characterization ...
openaire   +2 more sources

[The primary study on a novel protein binding to the death domain of the death receptor 4].

Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae, 2004
To clone and identify novel proteins binding to the death domain of the death receptor 4 (DR4).The yeast two-hybrid system was used for this study. Automatic sequencing was carried out for DNA sequencing. The sequence homology and the functional domains were analyzed by BLAST and the ScanProsite Tool softwares, respectively. Co-immunoprecipitate method
Xiao-ling, Li, Yan-xin, Liu, Shi-lian, Liu, De-xian, Zheng   +3 more
openaire   +1 more source

Induction of cell death by myristylated death domain of p55 TNF receptor is not abolished by Iprcg-like point mutation in death domain.

Journal of inflammation, 1997
We transiently expressed the intracellular domains of p55 TNF receptor (TNFR1) as either a cytosolic- or a membrane-associated form and examined their effects on the endogenous receptor-mediated gene expression as well as on cell viability. We found that gene expression as measured by luciferase activity under NF-kappa B-controlling elements was ...
C H, Kim, Y H, Song, K, Park, Y, Oh, T H, Lee   +4 more
openaire   +1 more source

The Death Domain Superfamily in Intracellular Signaling of Apoptosis and Inflammation

Annual Review of Immunology, 2007
Hyun Ho Park, Su-Chang Lin, Jin Kuk Yang   +2 more
exaly  

"DEATH DOMAIN" CONTAINING RECEPTORS

2000
LEONG CLEMENT, PHILLIPS JOSEPH H
openaire   +5 more sources

Death Domain and Death Receptors

2008
openaire   +1 more source

Fire and death: the pyrin domain joins the death-domain superfamily

Comptes Rendus - Biologies, 2004
Markus G Grutter
exaly  

Cancer death rates in US congressional districts

Ca-A Cancer Journal for Clinicians, 2015
, Liora Sahar, Kenneth M Portier
exaly  

Crystallization and preliminary X-ray crystallographic studies of the oligomeric death-domain complex between PIDD and RAIDD

Acta Crystallographica Section F: Structural Biology Communications, 2007
Hyun Ho Park
exaly