Results 71 to 80 of about 288,899 (312)

Activation of an atypical plant NLR with an N-terminal deletion initiates cell death at the vacuole

EMBO Reports
Plants evolve nucleotide-binding leucine-rich repeat receptors (NLRs) to induce immunity. Activated coiled-coil (CC) domain containing NLRs (CNLs) oligomerize and form apparent cation channels promoting calcium influx and cell death, with the alpha-1 ...
Sruthi Sunil, Simon Beeh, Eva Stöbbe, Kathrin Fischer, Franziska Wilhelm, Aron Meral, Celia Paris, Luisa Teasdale, Zhihao Jiang, Lisha Zhang, Moritz Urban, Emmanuel Aguilar Parras, Thorsten Nürnberger, Detlef Weigel, Rosa Lozano-Duran, Farid El Kasmi   +15 more
doaj   +1 more source

NLRC5, AT THE HEART OF ANTIGEN PRESENTATION

Frontiers in Immunology, 2013
Nucleotide-binding domain and leucine-rich repeat containing receptors (NLRs) are intracellular proteins mainly involved in pathogen recognition, inflammatory responses, and cell death.
Andreas eNeerincx, Wilson eCastro, Greta eGuarda, Thomas A. Kufer   +3 more
doaj   +1 more source

Targeting Innate Immunity in Cancer Therapy

Vaccines, 2021
The majority of current cancer immunotherapy strategies target and potentiate antitumor adaptive immune responses. Unfortunately, the efficacy of these treatments has been limited to a fraction of patients within a subset of tumor types, with an ...
Srikrishnan Rameshbabu, Brian W. Labadie, Anna Argulian, Akash Patnaik   +3 more
doaj   +1 more source

Extensive regions of the FADD death domain are required for binding to the TRAIL receptor DR5 [PDF]

Cell Death & Differentiation, 2005
Extensive regions of the FADD death domain are required for binding to the TRAIL receptor ...
L R, Thomas, L M, Bender, M J, Morgan, A, Thorburn   +3 more
openaire   +2 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

The Role of Necroptosis in Cardiovascular Disease

Frontiers in Pharmacology, 2018
A newly discovered mechanism of cell death, programmed necrosis (necroptosis), combines features of both necrosis and apoptosis. Necroptosis is tightly modulated by a series of characteristic signaling pathways. Activating necroptosis by ligands of death
Shi Zhe-Wei, Ge Li-Sha, Li Yue-Chun
doaj   +1 more source

CD40 regulation of death domains containing receptors and their ligands on lymphoma B cells [PDF]

British Journal of Haematology, 1998
Within the tumour necrosis factor (TNF) family the induction of apoptosis is restricted to some ligand–receptors pairs, including TNF–TNF receptor type I (TNFRI/p55), FasL‐Fas, TNF‐related apoptosis‐inducing ligand (TRAIL) and its death‐receptors (DR)‐4 and ‐5. The pair CD40L–CD40 belongs to the same family but rescues B cells from apoptosis.
P, Ribeiro, N, Renard, K, Warzocha, C, Charlot, L, Jeandenant, E, Callet-Bauchu, B, Coiffier, G, Salles   +7 more
openaire   +2 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

The Cytoplasmic Domain of the Lymphotoxin-β Receptor Mediates Cell Death in HeLa Cells [PDF]

Journal of Biological Chemistry, 1999
Activation of lymphotoxin-beta receptor (LT-betaR) by conjugation with heterotrimeric lymphotoxin, LT-alpha1/beta2, or by cross-linking with anti-LT-betaR antibodies can trigger apoptosis. We have observed that overexpression of either LT-betaR or the cytoplasmic domain of LT-betaR (LT-betaR(CD)) also induces apoptosis, which may be attributed to the ...
M Y, Wu, P Y, Wang, S H, Han, S L, Hsieh
openaire   +2 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source