Results 171 to 180 of about 2,499,152 (288)

Engineering a Multifunctional Nanozyme Platform for Synergistic Melanoma Therapy: Integrating Enzyme Activity, Immune Activation, and Low‐Temperature Photothermal Effects

Angewandte Chemie, EarlyView.
This study innovatively develops a multifunctional, multienzyme‐active nanoplatform (FeCP@PDA‐GOx), aimed at overcoming the limitations of traditional cancer therapies and achieving precise, efficient, and long‐lasting melanoma treatment. By integrating starvation therapy, CDT, mPTT, and immunotherapy, FeCP@PDA‐GOx generates a multidimensional ...
Qihang Ding, Haowei Liu, Lishan Yan, Liang Chen, Yu Chen, Jong Seung Kim, Ling Mei   +6 more
wiley   +2 more sources

Subtype-specific dysregulation of biogenic amine-related genes and miRNAs in breast cancer: identification of DRD2, HRH2, and HRH4 as potential therapeutic targets in TNBC and HER2+ subtypes. [PDF]

Breast Cancer Res Treat
Sirek A, Sirek T, Nowakowski R, Borawski P, Ossowski P, Mitka-Krysiak K, Zmarzły N, Boroń K, Chalcarz M, Kuraszewska B, Szulik M, Boroń D, Grabarek BO.   +12 more
europepmc   +1 more source

The Relationship between Rest Tremor and Underlying Lewy Pathology in Essential Tremor: A Clinical‐Pathological Study of 201 Cases

Annals of Neurology, EarlyView.
Objectives Prospective studies demonstrated that essential tremor is a risk factor for Parkinson's disease. Identifying clinical markers for conversion from essential tremor to essential tremor‐Parkinson's disease would be of considerable value. Rest tremor can be present in advanced essential tremor and may be a harbinger of conversion. We examined (1)
Elan D. Louis, Nora C. Hernandez, Tomer Guy, Phyllis L. Faust   +3 more
wiley   +1 more source

G Protein Selectivity in Dopamine Receptors is Determined before GDP Release. [PDF]

Biochemistry
Tawfeeq C, Hilibrand AS, Smith JS, Portillo J, Kruse AC, Abrol R.   +5 more
europepmc   +1 more source

Nanoparticles Functionalized with Polymer Brushes for Gene Delivery

Advanced NanoBiomed Research, EarlyView.
The engineering of the next generation gene delivery vectors requires the precise control of the architecture and physicochemical interactions controlling the transport, targeting, uptake, and release of nucleic acid materials to targeted cells. Polymer brush‐functionalized nanomaterials offer unprecedented control over such design and properties, and ...
Carlos E. Neri‐Cruz, Julien E. Gautrot
wiley   +1 more source

SPLICEIT Fluorescent Sensor for Integrating Dopamine Release with Cellular Resolution

Angewandte Chemie, EarlyView.
“Single‐chain protein‐based ligand indication through a chimerically‐engineered integrator tool” (SPLICEIT) is a G‐protein coupled receptor‐based sensor design that leaves a permanent fluorescent mark. We show dopamine detection in primary cultured neurons with a fourfold signal increase normalized to an mCherry (mCh) marker.
Steven M. Havens, Brian Georgis, Jian Weng, Jessi Rodriguez, Hannah Rivett, Shadan Alrawi, Peng Li, Wenjing Wang   +7 more
wiley   +2 more sources

Clozapine: past, present and future. [PDF]

World Psychiatry
Correll CU.
europepmc   +1 more source

Exosomes in Intervertebral Disc Regeneration: Roles, Opportunities, and Challenges

Advanced NanoBiomed Research, EarlyView.
Factors of Intervertebral Disc Degeneration Extracellular Matrix (ECM) Exosomes and Intervertebral Disc Degeneration (IVDD) Exosome‐Mediated Therapy for IVDD of Different Cell Sources Application of Engineered Exosomes in IVDD Clinical Application of Exosomes in IVDD Treatment Conclusion and Future Perspectives. Intervertebral disc degeneration (IVDD),
Xianglong Zhou, Tianyi Xia, Jiheng Xiao, Jianhui Xiang, Hanhong Fang, Haoran Zhou, Yiqiang Hu, Liming Xiong   +7 more
wiley   +1 more source

Smoking, Obesity, and Post-Cessation Weight Gain: Neurobiological Intersection and Treatment Recommendations. [PDF]

J Multidiscip Healthc
Golden A, Davis JM.
europepmc   +1 more source

An Electrochemical Sensor for Tenofovir Monitoring

Advanced NanoBiomed Research, EarlyView.
A novel laser‐scribed graphene/ gold spiky nanostructures/molecularly imprinted polymer electrochemical sensor is developed for sensitive and selective detection of tenofovir (TFV) to support human immunodeficiency virus adherence monitoring. It showed a broad linear range (10 nM–200 μM), low detection limit (3 nM), and high recovery (92.5%–113%) in ...
Abdellatif Ait Lahcen, Gymama Slaughter
wiley   +1 more source