Results 91 to 100 of about 150,460 (322)

The effects of an adenosine A(2A) agonist as an adjunctive treatment to alleviate sensorimotor gating deficits in a rodent model of schizophrenia [PDF]

, 2020
The adenosine system has become a promising target for the treatment of schizophrenia due to its unique relationship with dopamine D2 receptors. Dopamine D2 receptors display heightened sensitivity in schizophrenia, and inhibition of these receptors has ...
Rauhuff, Hannah
core   +1 more source

The Functional DRD3 Ser9Gly Polymorphism (rs6280) Is Pleiotropic, Affecting Reward as Well as Movement [PDF]

, 2013
Abnormalities of motivation and behavior in the context of reward are a fundamental component of addiction and mood disorders. Here we test the effect of a functional missense mutation in the dopamine 3 receptor (DRD3) gene (ser9gly, rs6280) on reward ...
A Agrawal, A Malmberg, A Schosser, AA Grace, AC Tziortzi, Allison Nugent, Andreas Reif, Anthony A. Grace, AS Henderson, B Lerer, BH Schott, C Martin-Soelch, C Toma, CA Hodgkinson, CA Zarate Jr, CB Aiken, CH Lammers, Chantal Martin-Soelch, Colin A. Hodgkinson, D Martinez, David Goldman, DG Dikeos, DG Dikeos, DH Zald, DJ Vandenbergh, DM Segal, EA Rabiner, EG Jonsson, EG Jonsson, EV Gurevich, F Jeanneteau, F Sambataro, F Zhang, FK Maina, G Novak, GF Rowlands, H Deng, HN Koenig, I Bombin, J Costas, J Diaz, J Joutsa, J Maj, J Wei, JC Barrett, Joanna Szczepanik, Jonathan Savitz, JW Buckholtz, L Heimer, LM Oswald, M Hirvonen, M Laruelle, M Papp, M Pecina, MA Khaled, MJ Koepp, ML Bouthenet, NA Lassen, ND Volkow, ND Volkow, NE Goeders, NS Bamford, O Chernoloz, O Valenti, P Proitsi, P Sokoloff, Pei-Hong Shen, Peter Herscovitch, PM Fisher, R Bogdan, R Hwang, RA Rhodes, RE Carson, RG Shulman, RH Perlis, S Pappata, S Ridray, S Taylor, S Tsuchimine, SN Haber, T Kienast, T Pohjalainen, U Dannlowski, V Vengeliene, W Schultz, Wayne C. Drevets, WC Drevets, X Liu, Y Goto, YZ Liu, ZX Xi   +90 more
core   +3 more sources

Contribution of Addictovigilance data to assess adverse‐events linked to psychoactive substances in children and adolescents

British Journal of Clinical Pharmacology, EarlyView.
Aims We sought to characterize adverse events and deaths associated with the use of psychoactive substances in children and adolescents. Methods Two French Addictovigilance databases were analysed: spontaneous reports and deaths over the period 2016–2021, in subjects aged 10–<18 years. An unsupervised classification was implemented on consumption data (
Hélène Peyrière, Anne Batisse, Nathalie Fouilhé Sam‐Laï, Amélie Daveluy, Christine Fournier‐Choma, Sylvie Deheul, Cécile Chevalier, Clémence Lacroix, Valérie Gibaja, Aurélie Aquizerate, Stéphanie Pain, Emilie Jouanjus, Marie‐Christine Picot, Erika Nogue   +13 more
wiley   +1 more source

Spatial Frequency Selectivity Is Impaired in Dopamine D2 Receptor Knockout Mice

Frontiers in Integrative Neuroscience, 2018
Dopamine is a neurotransmitter implicated in several brain functions, including vision. In the present study, we investigated the impacts of the lack of D2 dopamine receptors on the structure and function of the primary visual cortex (V1) of D2-KO mice ...
Bruno Oliveira Ferreira Souza, Mira Abou Rjeili, Clémentine Quintana, Jean M. Beaulieu, Christian Casanova   +4 more
doaj   +1 more source

Tumor suppression and improvement in immune systems by specific activation of dopamine D1-receptor-expressing neurons in the nucleus accumbens

Molecular Brain, 2022
Recent research has suggested that the mesolimbic dopamine network that mainly terminates in the nucleus accumbens may positively control the peripheral immune system.
Daisuke Sato, Yusuke Hamada, Michiko Narita, Tomohisa Mori, Hiroyuki Tezuka, Yukari Suda, Kenichi Tanaka, Sara Yoshida, Hideki Tamura, Akihiro Yamanaka, Emiko Senba, Naoko Kuzumaki, Minoru Narita   +12 more
doaj   +1 more source

ITI-007 demonstrates brain occupancy at serotonin 5-HT2A and dopamine D2 receptors and serotonin transporters using positron emission tomography in healthy volunteers

, 2015
© 2015 Springer-Verlag Berlin Heidelberg.Rationale: Central modulation of serotonin and dopamine underlies efficacy for a variety of psychiatric therapeutics.
Bisuna, B, Brašić, JR, Davis, RE, Gapasin, L, Goldwater, DR, Guevara, MR, Kumar, A, Mates, S, Raymont, V, Vanover, KEE, Willis, W, Wong, DF, Ye, W, Zhou, Y   +13 more
core   +1 more source

Deciphering the skeletal interoceptive circuitry to control bone homeostasis

BMEMat, EarlyView.
This review introduces the skeletal interoceptive circuitry, covering the ascending signals from bone tissues to the brain (sensors), the central neural circuits that integrate this information and dispatch commands (CPU), and the descending pathways that regulate bone homeostasis (effectors).
Yefeng Wu, Jiusi Guo, Zhen Chen, Fengwei Zhang, Billy Kwok Chong Chow, Zhuofan Chen, Kelvin Wai‐Kwok Yeung, Wei Qiao   +7 more
wiley   +1 more source

Effects on turning of microinjections into basal ganglia of D1 and D2 dopamine receptors agonists and the cannabinoid CB1 antagonist SR141716A in a rat Parkinson's model

Neurobiology of Disease, 2004
Brain cannabinoid CB1 receptors are expressed in neural areas that contribute to movement such as basal ganglia, where they co-localize with dopamine D1 and D2 receptors.
Fadwa El Banoua, Isabel Caraballo, Juan A Flores, Beatriz Galan-Rodriguez, Emilio Fernandez-Espejo   +4 more
doaj  

Characterisation of AmphiAmR11, an amphioxus (Branchiostoma floridae) D2-dopamine-like G protein-coupled receptor.

PLoS ONE, 2013
The evolution of the biogenic amine signalling system in vertebrates is unclear. However, insights can be obtained from studying the structures and signalling properties of biogenic amine receptors from the protochordate, amphioxus, which is an ...
Asha L Bayliss, Peter D Evans
doaj   +1 more source

Dopamine D2 receptor occupancy and cognition in schizophrenia: analysis of the CATIE data.

Schizophrenia bulletin, 2013
INTRODUCTION Antipsychotic drugs exert antipsychotic effects by blocking dopamine D2 receptors in the treatment of schizophrenia. However, effects of D2 receptor blockade on neurocognitive function still remain to be elucidated.
H. Sakurai, R. Bies, S. Stroup, R. Keefe, T. Rajji, Takefumi Suzuki, D. Mamo, B. Pollock, Koichiro Watanabe, M. Mimura, H. Uchida   +10 more
semanticscholar   +1 more source