Results 101 to 110 of about 147,933 (225)

Modulation of mechanosensation by endogenous dopaminergic signaling in the lateral parabrachial nucleus in mice

PAIN Reports
. Introduction:. The lateral parabrachial nucleus (LPBN), a crucial hub for integrating and modulating diverse sensory information, is known to express both D1 and D2 dopamine receptors and receive dopaminergic inputs.
Ho Koo, Jigong Wang, Ramesh Pariyar, Regan M. Hammond, Jun-Ho La   +4 more
doaj   +1 more source

Beta band modulation by dopamine D2 receptors in the primary motor cortex and pedunculopontine nucleus in a rat model of Parkinson’s disease

Brain Research Bulletin, 2022
Beta band (12–30 Hz) hypersynchrony within the basal ganglia-thalamocortical network has been suggested as a hallmark of Parkinson’s disease (PD) pathophysiology. Abnormal beta band oscillations are found in the pedunculopontine nucleus (PPN) and primary
Xuenan Wang, Min Li, Jinlu Xie, Dadian Chen, Xiwen Geng, Shuang Sun, Bo Liu, Min Wang   +7 more
doaj  

Dissecting Dopamine D2 Receptor Signaling

, 2015
Dopamine D2 receptor (D2R) is a G protein-coupled receptor (GPCR) that activates G protein and arrestin signaling molecules. D2R antagonism has been a hallmark of antipsychotic medications for more than half a century. However, this drug-class is associated with substantial side effects that decrease quality of life and medication compliance.
openaire   +3 more sources

Modulatory Effects of Dopamine D2 Receptors on Spreading Depression in Rat Somatosensory Neocortex

Basic and Clinical Neuroscience, 2014
Introduction: Spreading depression (SD) is a propagating wave of depolarization followed by depression of the neuroglial activities and can modulate extracellular dopamine concentrations in the neocortex.
Anna Maria Haarmann, Maryam Jafarian, Fariba Karimzadeh, Ali Gorji   +3 more
doaj  

Synthesis and sar study of 2-substituted imidazo[2,1-b] [1,3]benzothiazoles and related compounds endowed with affinity for dopamine D₂ receptors as potential antipsychotics [PDF]

, 2008
Typical antipsychotic agents such as chlorpromazine and haloperidol block the D2 subtype of dopamine receptors in a direct relation to their clinical potency. In this context we have developed a series of (1,2-diphenyl-imidazolyl)piperazine derivatives
Asproni, Battistina, Kehler, Jan, Mura, Stefania, Porcu, Giovanna, Simula, Sergio   +4 more
core  

D2-like dopamine receptors mediate the response to amphetamine in a mouse model of ADHD

Neurobiology of Disease, 2007
The mechanisms underlying the effects of psychostimulants in attention deficit hyperactivity disorder (ADHD) are not well understood, but indirect evidence implicates D2 dopamine receptors. Here we dissect the components of dopaminergic neurotransmission
Xueliang Fan, Ellen J. Hess
doaj  

The Caenorhabditis elegans D2-like dopamine receptor DOP-2 physically interacts with GPA-14, a Gαi subunit [PDF]

Dopaminergic inputs are sensed on the cell surface by the seven-transmembrane dopamine receptors that belong to a superfamily of G-protein-coupled receptors (GPCRs).
Harbinder, Singh, Pandey, Pratima
core   +2 more sources

D2 dopamine receptors and personality traits [PDF]

Nature, 1997
J. Petter Gustavsson, Erik G. Jönsson, Lars Farde   +2 more
openaire   +3 more sources

Neuronal Excitation in the Ventral Tegmental Area Modulates the Micturition Reflex Mediated via the Dopamine D1 and D2 Receptors in Rats

Journal of Pharmacological Sciences, 2003
Involvement of the dopamine D1 and D2 receptors in the ventral tegmental area (VTA) in the micturition reflex was investigated using female Sprague Dawley rats under urethane anesthesia.
Kiyoshi Hashimoto, Tatsuya Oyama, Takahide Sugiyama, Young-Chol Park, Takashi Kurita   +4 more
doaj  

Rotigotine is a potent agonist at dopamine D1 receptors as well as at dopamine D2 and D3 receptors

British Journal of Pharmacology, 2015
M. Wood, V. Dubois, D. Scheller, M. Gillard   +3 more
semanticscholar   +1 more source