World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.ABSTRACT Allergic rhinitis (AR) is a chronic inflammatory disease of the nasal mucosa characterized by allergen sensitization and the involvement of multiple inflammatory mediators. Currently, the treatment of AR mainly includes symptomatic relief, anti‐inflammatory therapy, and nerve desensitization. However, these treatments have limitations in fully
Yue Gu +7 more
wiley +1 more source
Modulatory Effects of Dopamine D2 Receptors on Spreading Depression in Rat Somatosensory Neocortex
Basic and Clinical Neuroscience, 2014 Introduction: Spreading depression (SD) is a propagating wave of depolarization followed by depression of the neuroglial activities and can modulate extracellular dopamine concentrations in the neocortex.
Anna Maria Haarmann +3 more
doaj
L-Tetrahydropalamatine: A Potential New Medication for the Treatment of Cocaine Addiction [PDF]
, 2012 Levo-tetrahydropalmatine (l-THP) is an active constituent of herbal preparations containing plant species of the genera Stephania and Corydalis and has been approved and used in China for a number of clinical indications under the drug name Rotundine ...
Mantsch, John R., Wang, Jia Bei
core +1 more source
Risk of Dementia in Patients Suffering From Psychosis—A Danish Register‐Based Cohort Study
Acta Psychiatrica Scandinavica, EarlyView.ABSTRACT Objective To investigate the association of psychosis with subsequent risk of dementia and to explore any impact of age at psychosis onset. Methods Using the Danish National health registries, a total of 39,022 patients with a diagnosis of psychosis and a matched sample of 195,109 individuals without psychosis were included in the study.
Simone Normark +3 more
wiley +1 more source
D2 dopamine receptors and personality traits [PDF]
Nature, 1997 J. Petter Gustavsson +2 more
openaire +3 more sources
Management of xylazine toxicity, overdose, dependence, and withdrawal: A systematic review
The American Journal on Addictions, EarlyView.Abstract Background and Objectives Xylazine, an alpha‐2‐adrenergic agonist, has been increasingly implicated in substance use and overdose crises. However, little is known about its effects on humans. With the growing public health crisis surrounding xylazine, it has become important to recognize and promptly manage symptoms of xylazine toxicity ...
Philipa Owusu‐Antwi +4 more
wiley +1 more source
Endogenous Dopamine and Endocannabinoid Signaling Mediate Cocaine-Induced Reversal of AMPAR Synaptic Potentiation in the Nucleus Accumbens Shell [PDF]
, 2018 Repeated exposure to drugs of abuse alters the structure and function of neural circuits mediating reward, generating maladaptive plasticity in circuits critical for motivated behavior.
Hearing, Matthew +3 more
core +2 more sources
Exploring the Link Between Headache, Possible Sleep Bruxism and Self‐Medication in Adolescents
Acta Paediatrica, EarlyView.ABSTRACT Aim Adolescents predominantly suffer from headaches and sleep bruxism. Yet, the association between both conditions remains unclear. This study investigated the relationship between primary headaches and possible sleep bruxism in adolescents. Methods A cross‐sectional study was conducted from August 24 to October 13, 2022, with 567 adolescents
M. C. P. do Nascimento +5 more
wiley +1 more source
Preclinical models for evaluating psychedelics in the treatment of major depressive disorder
British Journal of Pharmacology, EarlyView.Psychedelic drugs have seen a resurgence in interest as a next generation of psychiatric medicines with potential as rapid‐acting antidepressants (RAADs). Despite promising early clinical trials, the mechanisms which underlie the effects of psychedelics are poorly understood.
Laith Alexander +5 more
wiley +1 more source