Results 151 to 160 of about 111,594 (254)

The fast‐dissociating D2 antagonist antipsychotic JNJ‐37822681 is a neuronal Kv7 channel opener: Potential repurposing for epilepsy treatment

British Journal of Pharmacology, Volume 182, Issue 22, Page 5574-5595, November 2025.
Abstract Background and Purpose Pharmacological activation of neuronal M‐current mediated by Kv7 (Kv7.2–5) potassium channels is a validated mechanism for epilepsy treatment. However, since the market withdrawal of the prototype Kv7 activator retigabine, no Kv7 activator is clinically available for this condition.
Lidia Carotenuto, Oliver Keminer, Giusy Carleo, Andrea Zaliani, Antonio Leo, Rita Citraro, Giovambattista De Sarro, Nina Dirkx, Marcus Kaji, Sarah Weckhuysen, Jeanette Reinshagen, Vincenzo Barrese, Natascia Guida, Carmine Ostacolo, Francesco Miceli, Philip Gribbon, Maurizio Taglialatela   +16 more
wiley   +1 more source

Interaction Between Oxytocin and Dopamine Signaling: Focus on the Striatum. [PDF]

Int J Mol Sci
Guidolin D, Tortorella C, Cervetto C, Marcoli M, Maura G, Agnati LF.   +5 more
europepmc   +1 more source

Structure‐based discovery of thiamine uptake inhibitors

British Journal of Pharmacology, Volume 182, Issue 22, Page 5611-5626, November 2025.
Background and Purpose Thiamine (vitamin B1) is an essential coenzyme and catalyses various reactions in central metabolic pathways. Since mammals have lost the ability to synthesise thiamine de novo, this micronutrient has to be imported via the high affinity solute carriers SLC19A2 and A3 across the plasma membrane.
Florian Gabriel, Björn Windshügel, Christian Löw   +2 more
wiley   +1 more source

Targeting pro-dopaminergic agonism to attenuate and depression in patient's displaying genetic/epigenetic predisposition to hypodopaminergia. [PDF]

Front Public Health
Lewandrowski KU, Blum K, Lewandrowski APL, Thanos PK, Pinhasov A, Sharafshah A, Baron D, Gold MS, Dennen CA, Elman I, Bowirrat A, Modestino EJ, Zeine F, Jafari N, Sunder K, Makale MT, Giordano J, Gondre-Lewis MC, Lindenau M, Fuehrlein BS, Badgaiyan RD, Levin C, Schmidt SL, Fiorelli RKA.   +23 more
europepmc   +1 more source

PharmGKB summary [PDF]

Pharmacogenetics and Genomics, 2011
Teri E. Klein, Russ B. Altman, Katrin Sangkuhl, Paul Thomas, Huaiyu Mi, Huijun Z. Ring, Ruhong Jiang   +6 more
openaire   +3 more sources

Brain Network Signature of Autoscopic Phenomena in Humans

CNS Neuroscience &Therapeutics, Volume 31, Issue 11, November 2025.
This study identified a common brain network underlying AP, encompassing bilateral angular gyrus, posterior medial cortex, intraparietal sulcus, cuneus, fusiform and insula, and uncovered its multimodal signatures. These findings advance our understanding of the network mechanisms of AP, as well as provide novel insights into bodily self‐consciousness.
Siyi Wang, Lei Qi, Xinqi Huang, Chunxue Wu, Jialin Du, Qing Xue, Jinghui Liu, Yuanhong Chen, Liankun Ren   +8 more
wiley   +1 more source

Effect of pergolide treatment on insulin dysregulation in horses and ponies with pituitary pars intermedia dysfunction

Equine Veterinary Journal, Volume 57, Issue 6, Page 1612-1622, November 2025.
Abstract Background Due to the high frequency of laminitis reported for both conditions, the relationship between pituitary pars intermedia dysfunction (PPID) and insulin dysregulation (ID), and the potential role of dopamine in modifying insulin secretion, requires further investigation.
Nicolas C. Galinelli, Nicholas J. Bamford, Madison L. Erdody, Skye A. Mackenzie, Tobias Warnken, Patricia A. Harris, Martin N. Sillence, Simon R. Bailey   +7 more
wiley   +1 more source

Predicting Symptomatic Response to Prokinetic Treatment Using Gastric Alimetry

Neurogastroenterology &Motility, Volume 37, Issue 11, November 2025.
Gastric Alimetry biomarkers may help in the prediction of prokinetic response in patients with chronic gastroduodenal symptoms. Lower postprandial amplitudes, indicating a reduced meal response, appear to predict benefit. ABSTRACT Background Chronic neurogastroduodenal disorders are challenging to manage, with therapy often initiated on a trial and ...
Chris Varghese, Sibylle Van Hove, Gabriel Schamberg, Billy Wu, Nooriyah Poonawala, Mikaela Law, Nicky Dachs, Gen Johnston, India Fitt, Daphne Foong, Henry P. Parkman, Thomas Abell, Vincent Ho, Stefan Calder, Armen A. Gharibans, Christopher N. Andrews, Gregory O'Grady   +16 more
wiley   +1 more source

Transcranial Direct Current Stimulation in Parkinson's Disease Patients in the Off State: A Randomized Controlled Crossover Trial Examining the Effects on Pain With and Without the Influence of Dopaminergic Medication

Pain Practice, Volume 25, Issue 8, November 2025.
ABSTRACT Background tDCS has demonstrated hypoalgesic effects on Parkinson's disease (PD)‐related pain applied in the On state but not in the Off state. We aimed to determine the effect of tDCS in the Off state followed by dopaminergic medication on PD‐related pain.
Yeray González‐Zamorano, Marcos Moreno‐Verdú, Alexis Martínez‐Benito, Josué Fernández‐Carnero, Juan Pablo Romero   +4 more
wiley   +1 more source

D1 Receptor Agonist Ameliorates Synaptic and Behavioral Deficits in a Shank3‐Deficient Mouse Model of Autism

MedComm, Volume 6, Issue 11, November 2025.
Jun‐Sik Kim, Sukmin Han, Mihyeon An, Jinsu Park, Yeongyeong Lee, Jeein Lim, Sung Hyun Kim, Dong‐Gyu Jo   +7 more
wiley   +1 more source