Results 71 to 80 of about 151,968 (306)

The role of intracerebral dopamine D1 and D2 receptors in sleep‐wake cycles and general anesthesia

Ibrain, 2022
Dopamine (DA), a monoamine neurotransmitter, is synthesized and released mainly by neurons in the ventral tegmental area and the substantia nigra (SN) pars compacta of the midbrain.
Jie Zhang, Jia Li, Cheng‐Xi Liu, Huan Gui, Cheng‐Dong Yuan, Yi Zhang   +5 more
doaj   +1 more source

PACAP Signalling Network in the Nucleus Accumbens Core Regulates Reinstatement Behaviour in Rat. [PDF]

Addict Biol
This study demonstrates the presence of PACAP signalling in the nucleus accumbens, a key brain region for reward processing. In cocaine‐experienced rats, intra‐accumbal PACAP microinjection blocked cocaine‐induced reinstatement and prevented reinstatement driven by D1 but not D2 receptor activation, indicating circuit specificity. In the absence of FDA‐
Bose S, Simandl G, Hess EM, Kong L, Raddatz NJ, Maunze B, Choi S, Baker DA.   +7 more
europepmc   +2 more sources

Tetraspanin (TSP-17) Protects Dopaminergic Neurons against 6-OHDA-Induced Neurodegeneration in C. elegans [PDF]

, 2014
Parkinson's disease (PD), the second most prevalent neurodegenerative disease after Alzheimer's disease, is linked to the gradual loss of dopaminergic neurons in the substantia nigra.
A Garcia-Espana, A Moszczynska, A Priyadarshi, Alexander Holmes, Anton Gartner, AT Allen, B Giros, C Boucheix, C Boucheix, C Boucheix, C Klein, C Missale, CD Dunn, CH Lai, D Vallone, DB Calne, DL Chase, E Rubinstein, E Rubinstein, EA Bolan, ER Sawin, ES Calipari, FJ Lee, FJ Lee, GC Cotzias, GR Uhl, H Maharaj, H Moribe, H Moribe, HP Rang, J Bove, J Sulston, JE Galvin, JG White, JM Beaulieu, JW Langston, K Jellinger, K Strange, K Tieu, KF Tipton, Kim A. Caldwell, L Carvelli, LD Jayanthi, M Santiago, MJ Ferris, MJ LaVoie, MJ Zigmond, ML Toth, MS Szczypka, MW Davis, MY Chang, N Chen, Neda Masoudi, O Thompson, P Seeman, P Seeman, P Sokoloff, Pablo Ibanez-Cruceyra, PW McDonald, QY Zhou, R Andrew, R Nass, R Nass, RM Kostrzewa, RR Gainetdinov, S Brenner, S Cao, S Charrin, S Fahn, S Fahn, S Thaminy, Sarah-Lena Offenburger, TN Chase, W Birkmayer, WA Cass, Y Glinka   +75 more
core   +5 more sources

Dopaminergic presynaptic modulation of nigral afferents: its role in the generation of recurrent bursting in substantia nigra pars reticulata neurons

Frontiers in Systems Neuroscience, 2011
Previous work has shown the functions associated with activation of dopamine presynaptic receptors in some substantia nigra pars reticulata (SNr) afferents: i) striatonigral terminals (direct pathway) posses presynaptic dopamine D1-class receptors whose ...
Jose De Jesus Aceves, Pavel E Rueda-Orozco, Ricardo eHernandez, Victor ePlata, Osvaldo eIbanez-Sandoval, Elvira eGalarraga, Jose eBargas   +6 more
doaj   +1 more source

The G protein-coupled receptor heterodimer network (GPCR-HetNet) and its hub components [PDF]

, 2014
G protein-coupled receptors (GPCRs) oligomerization has emerged as a vital characteristic of receptor structure. Substantial experimental evidence supports the existence of GPCR-GPCR interactions in a coordinated and cooperative manner.
Agnati, Luigi F, Borroto-Escuela, Dasiel O, Brito, Ismel, Di Palma, Michael, Duchou, Jolien, Fuxe, Kjell, Guidolin, Diego, Oflijan, Julia, Rivera, Alicia, Romero-Fernandez, Wilber, Skieterska, Kamila, Suárez-Boomgaard, Diana, Van Craenenbroeck, Kathleen   +12 more
core   +4 more sources

Striatal Dopamine D2/D3 Receptors Mediate Response Inhibition and Related Activity in Frontostriatal Neural Circuitry in Humans

Journal of Neuroscience, 2012
Impulsive behavior is thought to reflect a traitlike characteristic that can have broad consequences for an individual's success and well-being, but its neurobiological basis remains elusive.
D. Ghahremani, Buyean Lee, C. Robertson, G. Tabibnia, A. Morgan, Natalie G. De Shetler, Amira K. Brown, J. Monterosso, A. Aron, M. Mandelkern, R. Poldrack, E. London   +11 more
semanticscholar   +1 more source

Typical Applications and Flame‐Retardant Strategies for Organic Phase‐Change Materials

Carbon Energy, EarlyView.
ABSTRACT This study begins by exploring the typical practical applications of phase‐change materials (PCMs) in various industries, highlighting their importance in energy storage, temperature regulation, and thermal management. It then emphasizes the necessity of flame‐retardant functionalization tailored to the specific application scenarios of PCMs ...
Xiao‐Mei Yang, Tao Shi, Xiaodong Wang, Huan Liu, De‐Yi Wang, Guang‐Zhong Yin   +5 more
wiley   +1 more source

Dopamine D2 antagonist-induced striatal Nur77 expression requires activation of mGlu5 receptors by cortical afferents

Frontiers in Pharmacology, 2012
Dopamine D2 receptor antagonists modulate gene transcription in the striatum. However, the molecular mechanism underlying this effect remains elusive. Here we used the expression of Nur77, a transcription factor of the orphan nuclear receptor family, as ...
Jérôme eMaheux, Michel eSt-Hilaire, David eVoyer, Emanuele eTirotta, Emiliana eBorrelli, Claude eRouillard, Pierre-Paul eRompré, Daniel eLévesque   +7 more
doaj   +1 more source

Beta band modulation by dopamine D2 receptors in the primary motor cortex and pedunculopontine nucleus in a rat model of Parkinson’s disease

Brain Research Bulletin, 2022
Beta band (12–30 Hz) hypersynchrony within the basal ganglia-thalamocortical network has been suggested as a hallmark of Parkinson’s disease (PD) pathophysiology. Abnormal beta band oscillations are found in the pedunculopontine nucleus (PPN) and primary
Xuenan Wang, Min Li, Jinlu Xie, Dadian Chen, Xiwen Geng, Shuang Sun, Bo Liu, Min Wang   +7 more
doaj   +1 more source

A molecular basis for selective antagonist destabilization of dopamine D3 receptor quaternary organization [PDF]

, 2017
The dopamine D3 receptor (D3R) is a molecular target for both first-generation and several recently-developed antipsychotic agents. Following stable expression of this mEGFP-tagged receptor, Spatial Intensity Distribution Analysis indicated that a ...
Caltabiano, Gianluigi, Jiménez-Rosés, Mireia, Marsango, Sara, Millan, Mark J., Milligan, Graeme, Pediani, John D., Ward, Richard J.   +6 more
core   +2 more sources