Results 71 to 80 of about 147,933 (225)

Dopamine D-2 up-regulation in psychosis patients after antipsychotic drug treatment [PDF]

, 2020
Purpose of reviewRecently, it has been questioned whether the re-emergence of psychotic symptoms following antipsychotic discontinuation or dose reduction is attributable to underlying psychotic vulnerability or to rebound effects of chronic use of ...
de Vries, Erik F. J., Sommer, Iris E. C., Thompson, Ilse A.   +2 more
core   +1 more source

STRUCTURE OF THE D2 DOPAMINE RECEPTOR BOUND TO THE ATYPICAL ANTIPSYCHOTIC DRUG RISPERIDONE

Nature, 2018
Dopamine is a neurotransmitter that has been implicated in processes as diverse as reward, addiction, control of coordinated movement, metabolism and hormonal secretion.
Sheng Wang, T. Che, A. Levit, B. Shoichet, Daniel Wacker, B. Roth   +5 more
semanticscholar   +1 more source

Dopamine D2 antagonist-induced striatal Nur77 expression requires activation of mGlu5 receptors by cortical afferents

Frontiers in Pharmacology, 2012
Dopamine D2 receptor antagonists modulate gene transcription in the striatum. However, the molecular mechanism underlying this effect remains elusive. Here we used the expression of Nur77, a transcription factor of the orphan nuclear receptor family, as ...
Jérôme eMaheux, Michel eSt-Hilaire, David eVoyer, Emanuele eTirotta, Emiliana eBorrelli, Claude eRouillard, Pierre-Paul eRompré, Daniel eLévesque   +7 more
doaj   +1 more source

Preservation of dendritic D2 receptor transmission in substantia nigra dopamine neurons with age

Scientific Reports, 2023
Substantia nigra pars compacta (SNc) dopamine neurons are required for voluntary movement and reward learning, and advanced age is associated with motor and cognitive decline.
Eva Troyano-Rodriguez, Harris E. Blankenship, Kylie Handa, Sarah Y. Branch, Michael J. Beckstead   +4 more
doaj   +1 more source

Distinct regulation of dopamine D2S and D2L autoreceptor signaling by calcium [PDF]

, 2015
D2 autoreceptors regulate dopamine release throughout the brain. Two isoforms of the D2 receptor, D2S and D2L, are expressed in midbrain dopamine neurons. Differential roles of these isoforms as autoreceptors are poorly understood.
Buck, David C., Bunzow, James R., Gantz, Stephanie C., Neve, Kim A., Neve, Rachael L., Robinson, Brooks G., Williams, John T.   +6 more
core   +2 more sources

Dopamine D2 receptor function is compromised in the brain of the methionine sulfoxide reductase A knockout mouse [PDF]

, 2010
Previous research suggests that brain oxidative stress and altered rodent locomotor behavior are linked. We observed bio-behavioral changes in methionine sulfoxide reductase A knockout mice associated with abnormal dopamine signaling. Compromised ability
Dobrowsky, Rick T., Fowler, Stephen C., Johnson, Michael A., Levant, Beth, Moskovitz, Jackob, Oien, Derek B., Ortiz, Andrea Naomi, Rittel, Alexander G.   +7 more
core   +2 more sources

Role of dopamine D2 receptors in ischemia/reperfusion induced apoptosis of cultured neonatal rat cardiomyocytes

Journal of Biomedical Sciences, 2011
BackgroundMyocardial ischemia/reperfusion injury is the major cause of morbidity and mortality for cardiovascular diseases. Dopamine D2 receptors are expressed in cardiac tissues.
Hongzhu Li, Jin-ping Guo, Jun Gao, Li-ping Han, Chun-Ming Jiang, Hong-xia Li, Shu-zhi Bai, Weihua Zhang, Guang-wei Li, Li-na Wang, Hong Li, Yajun Zhao, Yan Lin, Ye Tian, Guangdong Yang, Rui Wang, Ling-Yun Wu, Bao‐feng Yang, Chang‐qing Xu   +18 more
semanticscholar   +1 more source

Spatial Frequency Selectivity Is Impaired in Dopamine D2 Receptor Knockout Mice

Frontiers in Integrative Neuroscience, 2018
Dopamine is a neurotransmitter implicated in several brain functions, including vision. In the present study, we investigated the impacts of the lack of D2 dopamine receptors on the structure and function of the primary visual cortex (V1) of D2-KO mice ...
Bruno Oliveira Ferreira Souza, Mira Abou Rjeili, Clémentine Quintana, Jean M. Beaulieu, Christian Casanova   +4 more
doaj   +1 more source

Tumor suppression and improvement in immune systems by specific activation of dopamine D1-receptor-expressing neurons in the nucleus accumbens

Molecular Brain, 2022
Recent research has suggested that the mesolimbic dopamine network that mainly terminates in the nucleus accumbens may positively control the peripheral immune system.
Daisuke Sato, Yusuke Hamada, Michiko Narita, Tomohisa Mori, Hiroyuki Tezuka, Yukari Suda, Kenichi Tanaka, Sara Yoshida, Hideki Tamura, Akihiro Yamanaka, Emiko Senba, Naoko Kuzumaki, Minoru Narita   +12 more
doaj   +1 more source

Effects on turning of microinjections into basal ganglia of D1 and D2 dopamine receptors agonists and the cannabinoid CB1 antagonist SR141716A in a rat Parkinson's model

Neurobiology of Disease, 2004
Brain cannabinoid CB1 receptors are expressed in neural areas that contribute to movement such as basal ganglia, where they co-localize with dopamine D1 and D2 receptors.
Fadwa El Banoua, Isabel Caraballo, Juan A Flores, Beatriz Galan-Rodriguez, Emilio Fernandez-Espejo   +4 more
doaj