Results 11 to 20 of about 6,763,423 (338)

G protein-coupled receptors: structure- and function-based drug discovery

Signal Transduction and Targeted Therapy, 2021
As one of the most successful therapeutic target families, G protein-coupled receptors (GPCRs) have experienced a transformation from random ligand screening to knowledge-driven drug design.
Dehua Yang, Qingtong Zhou, Viktorija Labroska, Shanshan Qin, Sanaz Darbalaei, Yiran Wu, Elita Yuliantie, Linshan Xie, Houchao Tao, Jianjun Cheng, Qing Liu, Suwen Zhao, Wenqing Shui, Yi Jiang, Ming-Wei Wang   +14 more
doaj   +2 more sources

Genetic inference of on-target and off-target side-effects of antipsychotic medications. [PDF]

PLoS Genetics
It is often difficult to ascertain whether patient-reported side-effects are caused by a drug, and if so, through which mechanism. Adverse side-effects are the primary cause of antipsychotic drug discontinuation rather than poor efficacy.
Andrew R Elmore, Aws Sadik, Lavinia Paternoster, Golam M Khandaker, Tom R Gaunt, Gibran Hemani   +5 more
doaj   +2 more sources

Progress in structure-based drug development targeting chemokine receptors [PDF]

Frontiers in Pharmacology
As a critical subfamily of G protein-coupled receptors (GPCRs), chemokine receptors (CCRs) play pivotal regulatory roles in immune cell migration, inflammatory modulation, tissue regeneration, and tumor microenvironment (TME) remodeling.
Jin Wang, Chen Qu, Peng Xiao, Sijin Liu, Jin-Peng Sun, Yu-Qi Ping   +5 more
doaj   +2 more sources

The Connection of Azole Fungicides with Xeno-Sensing Nuclear Receptors, Drug Metabolism and Hepatotoxicity. [PDF]

Cells, 2020
Azole fungicides, especially triazole compounds, are widely used in agriculture and as pharmaceuticals. For a considerable number of agricultural azole fungicides, the liver has been identified as the main target organ of toxicity.
Marx-Stoelting P, Knebel C, Braeuning A.
europepmc   +2 more sources

P2X Receptors as Drug Targets [PDF]

Molecular Pharmacology, 2013
The study of P2X receptors has long been handicapped by a poverty of small-molecule tools that serve as selective agonists and antagonists. There has been progress, particularly in the past 10 years, as cell-based high-throughput screening methods were applied, together with large chemical libraries.
R. Alan North, Michael F. Jarvis
openaire   +4 more sources

PEGylated exenatide injection (PB-119) improves beta-cell function and insulin resistance in treatment-naïve type 2 diabetes mellitus patients

Frontiers in Pharmacology, 2023
Objective: PB-119, a PEGylated exenatide injection, is a once-weekly glucagon-like peptide-1 receptor agonist. In the present study, we aimed to evaluate the effects of PB-119 on insulin resistance and beta-cell function in Chinese patients with type 2 ...
Xu Liu, Xu Liu, Xu Liu, Ling Song, Ling Song, Ling Song, Yuanhui Zhang, Haiyan Li, Haiyan Li, Haiyan Li, Cheng Cui, Cheng Cui, Cheng Cui, Dongyang Liu, Dongyang Liu, Dongyang Liu   +15 more
doaj   +1 more source

WNT ligands in non-small cell lung cancer: from pathogenesis to clinical practice

Discover Oncology, 2023
Non-small cell lung cancer (NSCLC) is the malignant tumor with the highest morbidity and leading cause of death worldwide, whereas its pathogenesis has not been fully elucidated.
Wanting Xue, Lihong Cai, Su Li, Yujia Hou, Yan-Dong Wang, Dongbin Yang, Yubing Xia, Xiaobo Nie   +7 more
doaj   +1 more source

Diagnostic and therapeutic strategies for non-alcoholic fatty liver disease

Frontiers in Pharmacology, 2022
The global incidence rate of non-alcoholic fatty liver disease (NAFLD) is approximately 25%. With the global increase in obesity and its associated metabolic syndromes, NAFLD has become an important cause of chronic liver disease in many countries ...
Yajie Fu, Yanzhi Zhou, Linhu Shen, Xuewen Li, Haorui Zhang, Yeqi Cui, Ke Zhang, Weiguo Li, Wei-dong Chen, Wei-dong Chen, Shizhen Zhao, Yunfu Li, Wenling Ye   +12 more
doaj   +1 more source

Role of G-protein coupled receptors in cardiovascular diseases

Frontiers in Cardiovascular Medicine, 2023
Cardiovascular diseases (CVDs) are the leading cause of death globally, with CVDs accounting for nearly 30% of deaths worldwide each year. G-protein-coupled receptors (GPCRs) are the most prominent family of receptors on the cell surface, and play an ...
Yuanqiang Li, Boyu Li, Wei-Dong Chen, Wei-Dong Chen, Yan-Dong Wang   +4 more
doaj   +1 more source

Emerging Roles of Wnt Ligands in Human Colorectal Cancer

Frontiers in Oncology, 2020
Colorectal cancer (CRC) is the fourth leading cause of cancer death worldwide, and constitutive activation of the Wnt signaling pathway is universal in most CRC cases.
Xiaobo Nie, Huiyang Liu, Lei Liu, Yan-Dong Wang, Wei-Dong Chen, Wei-Dong Chen   +5 more
doaj   +1 more source