Results 11 to 20 of about 6,686,909 (365)

Emerging Roles of Wnt Ligands in Human Colorectal Cancer

Frontiers in Oncology, 2020
Colorectal cancer (CRC) is the fourth leading cause of cancer death worldwide, and constitutive activation of the Wnt signaling pathway is universal in most CRC cases.
Xiaobo Nie, Huiyang Liu, Lei Liu, Yan-Dong Wang, Wei-Dong Chen, Wei-Dong Chen   +5 more
doaj   +1 more source

The Apelin/APJ System in Psychosis and Neuropathy

Frontiers in Pharmacology, 2020
Apelin, an endogenous neuropeptide, has been identified as the cognate ligand for the G-protein-coupled receptor APJ. Apelin, APJ messenger RNA, and protein are widely expressed in the central nervous system and peripheral tissues of humans and animals ...
Shuang-Yu Lv, Wei-Dong Chen, Wei-Dong Chen, Yan-Dong Wang   +3 more
doaj   +1 more source

Downregulation of Wnt3 Suppresses Colorectal Cancer Development Through Inhibiting Cell Proliferation and Migration

Frontiers in Pharmacology, 2019
The aberrant expression of Wnt3 has linked to several types of human malignancies. However, it is not known for its role in tumorigenesis of colorectal cancer (CRC).
Xiaobo Nie, Fulin Xia, Ying Liu, Yun Zhou, Wenling Ye, Panha Hean, Jiming Meng, Huiyang Liu, Lei Liu, Jianxun Wen, Xuequn Ren, Wei-Dong Chen, Wei-Dong Chen, Yan-Dong Wang   +13 more
doaj   +1 more source

Nuclear receptors in vascular biology [PDF]

, 2015
Nuclear receptors sense a wide range of steroids and hormones (estrogens, progesterone, androgens, glucocorticoid, and mineralocorticoid), vitamins (A and D), lipid metabolites, carbohydrates, and xenobiotics.
A Chawla, A McCurley, AA Hamers, AL Bookout, B Fisslthaler, BG Hoebel, C McCarthy, C Zhou, CH Lee, CK Glass, CK Huang, CT Lee, D Bishop-Bailey, D Bishop-Bailey, David Bishop-Bailey, DP Edwards, E Gerlach, F Akbiyik, FA Pereira, FL Wynne, FY Ali, G Pascual, I Dussault, I Spoletini, J He, J Qin, J Sonoda, J Xiang, K Spruiell, KE Swales, L Calza, L Li, L Piqueras, LA Moraes, LA Moraes, LJ Jonk, LR You, M Kaushik, M Matic, N Albermann, N Schafer, N Takamoto, Q Qin, R Zhao, S Asgary, S Chakrabarti, S Marino De, S Stein, SA Kliewer, V Zoete, W El-Sankary, WC Lau, X Wang, Y Ma, Y Sui, Y Sui, YW Hu   +56 more
core   +1 more source

Emerging Roles of NPQ/Spexin in Physiology and Pathology

Frontiers in Pharmacology, 2019
Spexin (SPX), also called neuropeptide Q (NPQ), is a novel endogenous neuropeptide. Spexin gene and protein are widely expressed in central nervous system and peripheral tissues in humans, rodents, goldfish, etc.
Shuang-Yu Lv, Yu-Chen Zhou, Xiao-Mei Zhang, Wei-Dong Chen, Wei-Dong Chen, Yan-Dong Wang   +5 more
doaj   +1 more source

A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response [PDF]

, 2008
The pregnane X receptor (PXR) and the constitutive androstane receptor (CAR) are closely related orphan nuclear hormone receptors that play a critical role as xenobiotic sensors in mammals.
Anja Rode, Baes, Bauer, Branko Zevnik, C. Roland Wolf, Dotzlaw, Forrester, Hustert, Jillian Ross, Kocarek, Lowry, Lukas, Meehan, Nico Scheer, Nicole Faust, Poland, Sandra Niehaves, Smith, Wolf, Wrighton   +19 more
core   +3 more sources

The Role of the Apelin/APJ System in the Regulation of Liver Disease

Frontiers in Pharmacology, 2017
Apelin is an endogenous peptide that is a ligand for the APJ receptor (angiotensin II receptor like-1, AT-1). The apelin/APJ system is distributed in diverse periphery organ tissues.
Wei-Dong Chen, Wei-Dong Chen, Yan-Dong Wang, Xinrui Lv, Jing Kong   +4 more
doaj   +1 more source

Distinct inactive conformations of the dopamine D2 and D3 receptors correspond to different extents of inverse agonism

eLife, 2020
By analyzing and simulating inactive conformations of the highly homologous dopamine D2 and D3 receptors (D2R and D3R), we find that eticlopride binds D2R in a pose very similar to that in the D3R/eticlopride structure but incompatible with the D2R ...
J Robert Lane, Ara M Abramyan, Pramisha Adhikari, Alastair C Keen, Kuo-Hao Lee, Julie Sanchez, Ravi Kumar Verma, Herman D Lim, Hideaki Yano, Jonathan A Javitch, Lei Shi   +10 more
doaj   +1 more source

Drug‐resistant epilepsy: Drug target hypothesis and beyond the receptors

Epilepsia Open, 2022
Epilepsy is a chronic neurological disorder that affects more than 50 million people worldwide. Despite a recent introduction of antiseizure drugs for the treatment of epileptic seizures, one‐third of these patients suffer from drug‐resistant epilepsy ...
Daniel Fonseca‐Barriendos, Christian Lizette Frías‐Soria, Daniel Pérez‐Pérez, Rosenda Gómez‐López, Dasiel O. Borroto Escuela, Luisa Rocha   +5 more
doaj   +1 more source

Gain of function mutants: Ion channels and G protein-coupled receptors [PDF]

, 2000
Many ion channels and receptors display striking phenotypes for gain-of-function mutations but milder phenotypes for null mutations. Gain of molecular function can have several mechanistic bases: selectivity changes, gating changes including constitutive
Karschin, Andreas, Lester, Henry A.
core   +1 more source