Results 21 to 30 of about 6,519,345 (216)
Nuclear receptors: recent drug discovery for cancer therapies.
Endocrine reviews, 2019 Nuclear receptors (NRs) are transcription factors actively involved in many aspects of human physiology and pathology, serving as sensors of stimuli, master regulators of downstream molecular events and hubs governing complex gene regulatory networks ...
Linjie Zhao +2 more
semanticscholar +1 more source
Molecular Dynamics Simulations in Drug Discovery and Pharmaceutical Development
Processes, 2020 Molecular dynamics (MD) simulations have become increasingly useful in the modern drug development process. In this review, we give a broad overview of the current application possibilities of MD in drug discovery and pharmaceutical development. Starting
O. Salo-Ahen +18 more
semanticscholar +1 more source
Structure-Function Analyses of Human Bitter Taste Receptors—Where Do We Stand?
Molecules, 2020 The finding that bitter taste receptors are expressed in numerous tissues outside the oral cavity and fulfill important roles in metabolic regulation, innate immunity and respiratory control, have made these receptors important targets for drug discovery.
Maik Behrens, Florian Ziegler
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Molecular Simulations and Drug Discovery of Adenosine Receptors
Molecules, 2022 G protein-coupled receptors (GPCRs) represent the largest family of human membrane proteins. Four subtypes of adenosine receptors (ARs), the A1AR, A2AAR, A2BAR and A3AR, each with a unique pharmacological profile and distribution within the tissues in ...
Jinan Wang +4 more
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Ecotoxicology and Environmental SafetyAflatoxins, particularly aflatoxin B1 (AFB1), are widely present in the environment and pose a significant risk to food safety. However, no specific drugs are available for AFB1-induced toxic liver injury. Ganfule (GFL) is a traditional Chinese medicine (
Pan Li +10 more
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Pregnane Xenobiotic Receptors and Their Effect on Drug Elimination from the Organism
Prague Medical Report, 2013 Nuclear receptors are intracellular proteins which, having been activated by their more or less specific ligands, regulate (usually increase) the transcription of target genes.
Martin Šíma, I. Netíková, O. Slanař
doaj +1 more source
iScience, 2020 Summary: Compared with conventional chemotherapy and radiotherapy, targeted molecular therapy, e.g., antibody-drug conjugates or aptamer-drug conjugates, can specifically identify overexpressed natural receptors on the cancer cell, perform targeted ...
Hoda Safari Yazd +9 more
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Presynaptic G Protein-Coupled Receptors: Gatekeepers of Addiction?
Frontiers in Cellular Neuroscience, 2016 Drug abuse and addiction cause widespread social and public health problems, and the neurobiology underlying drug actions and drug use and abuse is an area of intensive research.
Kari A Johnson, David M Lovinger
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G protein-coupled receptors (GPCRs): advances in structures, mechanisms and drug discovery
Signal Transduction and Targeted TherapyG protein-coupled receptors (GPCRs), the largest family of human membrane proteins and an important class of drug targets, play a role in maintaining numerous physiological processes.
Mingyang Zhang +5 more
semanticscholar +1 more source
THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: G protein‐coupled receptors
British Journal of Pharmacology, 2019 The Concise Guide to PHARMACOLOGY 2019/20 is the fourth in this series of biennial publications. The Concise Guide provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where ...
Stephen P. H. Alexander +13 more
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