Results 121 to 130 of about 32,261 (224)

Pathogenic Gαo Mutants Drive Dominant GPCR Coupling in GNAO1 Encephalopathies

The FASEB Journal, Volume 40, Issue 1, 15 January 2026.
Mutations in GNAO1, the gene encoding Gαo, are associated with a wide range of neurodevelopmental disorders. In this study, we show that Gαo variants linked to the most severe patient phenotypes fail to disengage from activated Gi/o‐coupled GPCRs, thereby blocking GRK‐mediated receptor phosphorylation and internalization.
Yonika A. Larasati, Camille Rabesahala de Meritens, Miriam Stoeber, Vladimir L. Katanaev, Gonzalo P. Solis   +4 more
wiley   +1 more source

TERT expression in human prostate tissue reveals a potential molecular switch in benign prostatic hyperplasia progression. [PDF]

World J Urol
Xu Y, Hu S, Berger L, Nicola P, Weinhold P, Tamalunas A, Stief CG, Hennenberg M, Keller P.   +8 more
europepmc   +1 more source

The Involvement of the Peptidergic Systems in Breast Cancer Development. [PDF]

Cancers (Basel)
Sánchez ML, Robinson P, Italia Z, Hoang T, Muñoz M, Coveñas R.   +5 more
europepmc   +1 more source

Endogenous modulators in lung cancer. [PDF]

World J Clin Cases
Patel N, Patel V, Surani S.
europepmc   +1 more source

Signaling Molecules and Diagnosis of Cognitive Disorders: Current State and Prospects. [PDF]

Int J Mol Sci
Kvetnoy I, Kheyfets O, Safaniev L, Kheifets V, Mironova E, Kvetnaia T, Mazzoccoli G, Prashchayeu K, Gavrilova A.   +8 more
europepmc   +1 more source

Successful treatment of refractory chilblain lupus erythematosus with bosentan. [PDF]

Rheumatology (Oxford)
Gunawardana S, Clarke AJ, Lloyd-Lavery A, Dubey S.   +3 more
europepmc   +1 more source

Effects of phenylephrine and norepinephrine with restrictive infusion on oxygenation during one-lung ventilation for lung surgery: a randomized controlled trial. [PDF]

Ann Med
Li J, Liu X, Xu L, Liu Y, Liu Y.
europepmc   +1 more source

G Protein-Coupled Receptors in Cerebrovascular Diseases: Signaling Mechanisms and Therapeutic Opportunities. [PDF]

Int J Mol Sci
Gu Q, Yao J, Sheng J, Liu D.
europepmc   +1 more source

Endothelin 1 (EDN1; ET1); endothelin receptor [PDF]

Science-Business eXchange, 2013
openaire   +1 more source

Vasoactivity of Rac GTPase, Cytohesin and Kinase Inhibitors in Renal Interlobar and Coronary Arteries Reveals Shared and Distinct Patterns of Inhibitory Effects in Vascular and Prostate Smooth Muscle Contraction. [PDF]

Pharmacol Res Perspect
Liu G, Hu S, Tamalunas A, Kale O, Xu Y, Stief CG, Hennenberg M.   +6 more
europepmc   +1 more source