Results 201 to 210 of about 19,757 (238)
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Activation and inhibition of the erythropoietin receptor by a membrane-anchored erythropoietin
Experimental Hematology, 2008To investigate whether expression of a membrane-anchored form of erythropoietin (MbEpo) results in self-controlled, autocrine proliferation, and differentiation of erythroid cells. This would provide a possible approach to the selective expansion of genetically corrected erythroid cells in gene-therapy protocols.We designed retroviral vectors encoding ...
Olivier, Negre +6 more
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Erythropoietin Receptor Structural Domains
2017Erythropoietin (EPO) is a hormone that is important for regulating red blood cell production. It is functional through binding to its receptor-EpoR. EpoR is a single-span membrane protein. It contains an extracellular region, a transmembrane domain, and a C-terminus.
Qingxin, Li, CongBao, Kang
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Erythropoietin and erythropoietin receptor expression in normal and disturbed pregnancy
European Journal of Obstetrics & Gynecology and Reproductive Biology, 2008Erythropoietin (Epo) is known to regulate the number of circulating erythrocytes. Epo receptor (Epo-R) expression is limited to few organs including the uterus. We investigated differences in Epo and Epo-R expression in normal and disturbed first trimester human pregnancy.Placental tissue was obtained from normal human pregnancy, abortion and ...
Bettina, Toth +5 more
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Blood, 1999
Erythropoietin (EPO) is required for the survival and expansion of red blood cell progenitor cells and supports continued differentiation of these committed progenitors to mature red blood cells. After binding to its cognate receptor, EPO promotes receptor homodimerization, activation of receptor-associated JAK2, subsequent receptor tyrosine ...
D L, Beckman +3 more
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Erythropoietin (EPO) is required for the survival and expansion of red blood cell progenitor cells and supports continued differentiation of these committed progenitors to mature red blood cells. After binding to its cognate receptor, EPO promotes receptor homodimerization, activation of receptor-associated JAK2, subsequent receptor tyrosine ...
D L, Beckman +3 more
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Expression of Erythropoietin and Erythropoietin Receptor in Human Dental Pulp
Journal of Endodontics, 2010In addition to the involvement in erythropoiesis, erythropoietin (EPO) and its receptor (EPO-R) have been shown to be expressed in various nonhematopoietic organs and tissues with diverse biological effects. The purpose of this study was to evaluate the expression patterns of EPO and EPO-R in healthy and inflamed human dental pulp tissues.
Qimei, Gong +4 more
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The molecular physiology of erythropoietin and the erythropoietin receptor.
Current opinion in hematology, 1999Erythropoietin is the major glycoprotein hormone regulator of mammalian erythropoiesis. Erythropoietin is secreted by the kidney in response to decreased blood oxygen. It circulates in the blood, and binds and activates a specific receptor expressed on bone marrow erythroblasts.
Y, Zhu, A D, D'Andrea
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Glycosylation of Erythropoietin Receptor
1991The size of the murine erythropoietin (EPO) receptor (EPO-R), 105 kDa, estimated from EPO.EPO-R cross-linked products,is much higher than that, 53 kDa, predicted from EPO-R cDNA. The lectinbinding properties of the solubilized EPO-R suggested that EPO-R was N-glycosylated. To find whether glycosylation of EPO-R accounted for the difference in size, the
S. Masuda, Y. Hisada, M. Ueda, R. Sasaki
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Erythropoietin and erythropoietin receptor expression in human cancer.
Cancer research, 2001Erythropoietin (EPO) stimulates the growth of erythroblasts in the bone marrow (C. Lacombe and P. Mayeux, NEPHROL: DIAL: TRANSPLANT:, 14 (SUPPL: 2): 22-28, 1999). We report basal and hypoxia-stimulated expression of EPO and its receptor, EPOR, in human breast cancer cells, and we demonstrate EPO-stimulated tyrosine phosphorylation and the proliferation
G, Acs +6 more
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The role of erythropoietin and erythropoietin receptor in regulation of hemopoiesis
2009To analyze the molecular mechanisms by which erythropoietin (Epo) can stimulate proliferation and differentiation of hemopoietic cells, I studied the effects of quantitative and qualitative alterations in the expression of erythropoietin receptors (EpoRs) in hemopoietic cell lines and in the primary bone marrow cells using retrovirus mediated gene ...
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Erythropoietin and derivatives: Potential beneficial effects on the brain
Journal of Neurochemistry, 2021Daniela C Vittori
exaly