Results 71 to 80 of about 577,108 (265)

Erythropoietin and its receptors in the brainstem of adults with fatal falciparum malaria

Malaria Journal, 2009
Background Facilitation of endogenous neuroprotective pathways, such as the erythropoietin (Epo) pathway, has been proposed as adjuvant treatment strategies in cerebral malaria. Whether different endogenous protein expression levels of Epo or differences
White Nicholas J, Hien Tran, Day Nicholas PJ, Medana Isabelle M, Turner Gareth DH   +4 more
doaj   +1 more source

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

Cardioprotective Effects of Erythropoietin on Postresuscitation Myocardial Dysfunction in Appropriate Therapeutic Windows

, 2011
Objective: Erythropoietin has been noted for its cardioprotective effects . The objective of the study is to investigate its effects on postresuscitation myocardial dysfunction and therapeutic windows. Design: Randomized animal study.
HUANG, CHIEN-HUA;HSU, CHIUNG-YUAN;TSAI, MIN-SHAN;WANG, TZUNG-DAU;CHANG, WEI-TIEN;CHEN, WEN-JONE, 黃建華;許瓊元;蔡旼珊;王宗道;張維典;陳文鍾   +1 more
core   +1 more source

Advances and current concepts on Eph receptors and ephrins in upper digestive tract cancers

Frontiers in Oncology
Erythropoietin-producing hepatocellular (Eph) receptors comprise the largest group of surface receptors and are responsible for cellular signals. Eph/ephrin signaling has been identified to play a role in key cancer development and progression processes,
Luccas Lavareze, Luccas Lavareze, Talita de Carvalho Kimura, Talita de Carvalho Kimura, João Figueira Scarini, João Figueira Scarini, Reydson Alcides de Lima-Souza, Reydson Alcides de Lima-Souza, Moisés Willian Aparecido Gonçalves, Moisés Willian Aparecido Gonçalves, Raisa Sales de Sá, Raisa Sales de Sá, Iara Gonçalves Aquino, Iara Gonçalves Aquino, Patricia Maria Fernandes, Fernanda Cristina Poscai Ribeiro, Albina Altemani, Fernanda Viviane Mariano, Gary Chris Fillmore, Erika Said Abu Egal, Erika Said Abu Egal   +20 more
doaj   +1 more source

Bridging the translational gap in clinical nanomedicine: From rational design to clinical reality

BMEMat, EarlyView.
Nanotechnology offers a multi‐faceted approach to modern healthcare, encompassing high‐sensitivity diagnostic imaging, innovative vaccine delivery, and targeted therapeutics. This review explores how these nanomedicine applications address critical challenges in cancer recurrence and the treatment of neurologic and respiratory diseases to combat rising
Ahmed H. Ghonaim, Marwa Ahmed El‐Naka, Wedad M. Nageeb, Atta Ullah Khan, Noura M. Seleem, Aliaa Abdelghafar, Doaa Zamel, Yang Liu, Qigai He, Wentao Li   +9 more
wiley   +1 more source

Mechanisms controlling anaemia in Trypanosoma congolense infected mice. [PDF]

, 2009
Trypanosoma congolense are extracellular protozoan parasites of the blood stream of artiodactyls and are one of the main constraints on cattle production in Africa.
de Angelis Martin Hrabé, Eckard Wolf, Naessens, Jan, Fuchs Helmut, Hulme, Helen, Kemp, Stephen, Alimohammadian, M.H., Wolf, Eckard, Morris Agaba, Noyes, Harry A., Hrabě de Angelis, M., de Angelis, Martin Hrabé, Agaba, M., Angelis, M.H. de, Mohammad H Alimohammadian, Martin Hrabé de Angelis, Brass Andy, Hulme Helen, Delnaz Rosh, Rathkolb, Birgit, Roshandel, Delnaz, Noyes Harry A., Rathkolb, B., Iraqi, Fuad, Fuchs, H., Hrabé de Angelis, Martin, Stephen Kemp, Jan Naessens, Wolf, E., Naessens Jan, Alimohammadian Mohammad H., Gailus-Durner, V., Gailus-Durner Valerie, Martin Hrabe ́ De Angelis, Kemp, S., Brass, Andy, Helmut Fuchs, Agaba Morris, Iraqi Fuad, Harry A. Noyes, Andy Brass, Noyes, H.A., Helen Hulme, Agaba, Morris, Kemp, Stephen J., Iraqi, F., Iraqi, F.A., Kemp Stephen, Brass, A., Harry A Noyes, Roshandel, D., Wolf Eckard, Rathkolb Birgit, Naessens, J., Delnaz Roshandel, Birgit Rathkolb, Brass, Andy; id_orcid, Alimohammadian, Mohammad H., Fuchs, Helmut, Fuad Iraqi, Wolf, Eckhard, Valerie Gailus-Durner, Hulme, H., Gailus-Durner, Valerie, Mohammad H. Alimohammadian, Roshandel Delnaz, Noyes, H.A. ; Alimohammadian, M.H. ; Agaba, M. ; Brass, A. ; Fuchs, H. ; Gailus-Durner, V. ; Hulme, H. ; Iraqi, F. ; Kemp, S. ; Rathkolb, B. ; Wolf, E. ; Hrabé de Angelis, M. ; Roshandel, D. ; Naessens, J.   +66 more
core   +2 more sources

TAM receptors and the regulation of erythropoiesis in mice

Haematologica, 2009
Background TAM receptors (Tyro3, Axl and Mer) are expressed in hematopoietic tissues. The roles of the three receptors in hematopoiesis are, however, largely unknown.
Hongmei Tang, Song Chen, Haikun Wang, Hui Wu, Qingxian Lu, Daishu Han   +5 more
doaj   +1 more source

Differentiation Domains of the Erythropoietin Receptor

Experimental Biology and Medicine, 1994
Ectopic expression of the erythropoietin receptor (Epo-R) in Ba/F3, an interleukin-3 (IL-3)-dependent progenitor cell line, confers both Epo-dependent cell growth and Epo-dependent induction of beta-globin mRNA. We have used this system of limited erythroid differentiation to characterize the role of the Epo-R in differentiation. In particular, we have
M, Carroll, B, Mathey-Prevot, A, D'Andrea   +2 more
openaire   +2 more sources

Erythropoietin and erythropoietin receptor expression in human prostate cancer [PDF]

Modern Pathology, 2005
Erythropoietin is a hematopoietic cytokine that regulates the production of red blood cells. Erythropoietin is normally produced in the adult kidney in a hypoxia-inducible manner. The recombinant form of human erythropoietin is in clinical use for the prevention and treatment of anemia that is associated with cancer and its treatment with ...
Murat O, Arcasoy, Khalid, Amin, Robin T, Vollmer, Xiaohong, Jiang, Wendy, Demark-Wahnefried, Zishan A, Haroon   +5 more
openaire   +2 more sources

C‐Terminal Functionalization Methods of Amino Acids, Peptides, and Proteins

Chemistry – A European Journal, EarlyView.
C‐terminal functionalization offers powerful routes to peptide and protein diversification, yet epimerization, hydrolysis, and selectivity remain key challenges. This Review surveys enzymatic, decarboxylative, and condensation strategies, highlighting advances toward chemo‐ and regioselective, protecting‐group‐free, atom‐efficient methods applicable to
Jay Hanssens, Mark Lambers, Romano V. A. Orru, Jordy M. Saya   +3 more
wiley   +1 more source