Results 51 to 60 of about 19,757 (238)

Porcine kidney xenotransplantation: From primate models to clinical reality

Animal Models and Experimental Medicine, EarlyView.
In the face of a critical shortage of human donor kidneys for end‐stage renal disease patients, porcine kidney xenotransplantation has emerged as a viable solution. This field has navigated major hurdles, including immune rejection, physiological incompatibilities, potential biomechanical differences and the risk of cross‐species infection. To overcome
Zihang Guo, Ling Zhang, Shoulong Deng, Chuan Qin   +3 more
wiley   +1 more source

Erythropoietin and its receptors in the brainstem of adults with fatal falciparum malaria

Malaria Journal, 2009
Background Facilitation of endogenous neuroprotective pathways, such as the erythropoietin (Epo) pathway, has been proposed as adjuvant treatment strategies in cerebral malaria. Whether different endogenous protein expression levels of Epo or differences
White Nicholas J, Hien Tran, Day Nicholas PJ, Medana Isabelle M, Turner Gareth DH   +4 more
doaj   +1 more source

Investigating the Role of Type I Interferon Signaling on Muscle Disease Using Mouse Models

Arthritis &Rheumatology, EarlyView.
Objective Dysregulated type I interferon (IFN) signaling contributes to autoimmune myositis pathogenesis. We investigated the therapeutic effects of JAK inhibitors in two mouse models. We also examined how type I IFNs affect muscle vasculature. Methods Myositis was induced in major histocompatibility complex class I double transgenic ([TRE‐H‐2Kb (H ...
Rita Spathis, Sabrina Narvesen, Deeva Robles Kuriplach, Karen Huang, Teja Sundar, Elizabeth Bagley, Joanna Parkes, Xinyu Jia, Nandhana Sudhan, Alfredo Guzman, Kanneboyina Nagaraju, Melissa Morales   +11 more
wiley   +1 more source

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

Advances and current concepts on Eph receptors and ephrins in upper digestive tract cancers

Frontiers in Oncology
Erythropoietin-producing hepatocellular (Eph) receptors comprise the largest group of surface receptors and are responsible for cellular signals. Eph/ephrin signaling has been identified to play a role in key cancer development and progression processes,
Luccas Lavareze, Luccas Lavareze, Talita de Carvalho Kimura, Talita de Carvalho Kimura, João Figueira Scarini, João Figueira Scarini, Reydson Alcides de Lima-Souza, Reydson Alcides de Lima-Souza, Moisés Willian Aparecido Gonçalves, Moisés Willian Aparecido Gonçalves, Raisa Sales de Sá, Raisa Sales de Sá, Iara Gonçalves Aquino, Iara Gonçalves Aquino, Patricia Maria Fernandes, Fernanda Cristina Poscai Ribeiro, Albina Altemani, Fernanda Viviane Mariano, Gary Chris Fillmore, Erika Said Abu Egal, Erika Said Abu Egal   +20 more
doaj   +1 more source

TAM receptors and the regulation of erythropoiesis in mice

Haematologica, 2009
Background TAM receptors (Tyro3, Axl and Mer) are expressed in hematopoietic tissues. The roles of the three receptors in hematopoiesis are, however, largely unknown.
Hongmei Tang, Song Chen, Haikun Wang, Hui Wu, Qingxian Lu, Daishu Han   +5 more
doaj   +1 more source

New insights into erythropoietin and erythropoietin receptor in laryngeal cancer tissue

Medicine, 2021
Abstract To investigate whether laryngeal cancer cells express erythropoietin (Epo) and erythropoietin receptor (EpoR) and what is their possible relationship with clinical and pathological features of the tumor. We performed immunohistochemical analysis of Epo and EpoR expression on 78 tissue samples of invasive ...
Jelena Vukelic, Renata Dobrila-Dintinjana, Blazen Marijic, Diana Marzic, Tamara Braut, Marko Velepic   +5 more
openaire   +3 more sources

Dried blood spot analysis in antidoping: Technical challenges, analytical advances, and future perspectives

Bulletin of the Korean Chemical Society, EarlyView.
Dried blood spot (DBS) analysis enables minimally invasive blood collection with strong analyte stability and simplified logistics, supporting anti‐doping applications beyond traditional matrices. Recent advances address hematocrit, volume variability, and matrix effects while expanding coverage to steroid esters, World Anti‐Doping Agency‐listed ...
Jihyun Yoon, Jiyeong Hong, Hanbin Oh, Chi Hwan Lee, Ki Hun Kim   +4 more
wiley   +1 more source

Prognostic significance of erythropoietin and erythropoietin receptor in gastric adenocarcinoma

World Journal of Gastroenterology, 2011
To investigate the expression of Erythropoietin (Epo) and its receptor (EpoR) in gastric adenocarcinoma (GAC) and the correlation with angiogenesis and clinicopathological features.The expressions of Epo, EpoR and vascular endothelial growth factor (VEGF), as well as microvessel density were evaluated in 172 GAC biopsies by immunohistochemical staining.
Lin, Wang, Hai-Gang, Li, Zhong-Sheng, Xia, Jian-Ming, Wen, Jun, Lv   +4 more
openaire   +2 more sources

A Systematic Review on Disease‐Modifying Therapies in Parkinsonian Disorders

Clinical Pharmacology &Therapeutics, EarlyView.
Parkinsonian disorders, including Parkinson's disease, Lewy body dementia, multiple system atrophy, and progressive supranuclear palsy, are progressive neurodegenerative conditions with no treatment options to slow disease progression. This systematic review provides an overview of evidence of disease‐modifying therapies that have been evaluated in ...
Pepijn P.N.M. Eijsvogel, Lars M.G. Smits, Philip H.C. Kremer, Geert Jan Groeneveld   +3 more
wiley   +1 more source