Results 31 to 40 of about 19,757 (238)

The Orphan Cytokine Receptor CRLF3 Emerged With the Origin of the Nervous System and Is a Neuroprotective Erythropoietin Receptor in Locusts

Frontiers in Molecular Neuroscience, 2019
The orphan cytokine receptor-like factor 3 (CRLF3) was identified as a neuroprotective erythropoietin receptor in locust neurons and emerged with the evolution of the eumetazoan nervous system.
Nina Hahn, Luca Büschgens, Nicola Schwedhelm-Domeyer, Sarah Bank, Bart R. H. Geurten, Pia Neugebauer, Bita Massih, Martin C. Göpfert, Ralf Heinrich   +8 more
doaj   +1 more source

Recent advances of the Ephrin and Eph family in cardiovascular development and pathologies

iScience
Summary: Erythropoietin-producing hepatoma (Eph) receptors, comprising the largest family of receptor tyrosine kinases (RTKs), exert profound influence on diverse biological processes and pathological conditions such as cancer.
Yuan Zhu, Sheng-an Su, Jian Shen, Hong Ma, Jixie Le, Yao Xie, Meixiang Xiang   +6 more
doaj   +1 more source

Association between high-dose erythropoiesis-stimulating agents, inflammatory biomarkers, and soluble erythropoietin receptors

BMC Nephrology, 2011
Background High-dose erythropoiesis-stimulating agents (ESA) for anemia of chronic kidney disease (CKD) have been associated with adverse clinical outcomes and do not always improve erythropoiesis.
Inrig Jula K, Bryskin Suzanne K, Patel Uptal D, Arcasoy Murat, Szczech Lynda A   +4 more
doaj   +1 more source

The cytokine receptor CRLF3 is a human neuroprotective EV-3 (Epo) receptor

Frontiers in Molecular Neuroscience, 2023
The evolutionary conserved orphan cytokine receptor-like factor 3 (CRLF3) has been implicated in human disease, vertebrate hematopoiesis and insect neuroprotection.
Debbra Y. Knorr, Ignacio Rodriguez Polo, Ignacio Rodriguez Polo, Ignacio Rodriguez Polo, Ignacio Rodriguez Polo, Hanna S. Pies, Nicola Schwedhelm-Domeyer, Stephanie Pauls, Rüdiger Behr, Rüdiger Behr, Ralf Heinrich   +10 more
doaj   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Dysregulation of erythropoiesis and altered erythroblastic NMDA receptor-mediated calcium influx in Lrfn2-deficient mice.

PLoS ONE, 2021
LRFN2 encodes a synaptic adhesion-like molecule that physically interacts with N-methyl-D-aspartate (NMDA) receptor 1 and its scaffold proteins. Previous studies in humans and mice have demonstrated its genetic association with neurodevelopmental ...
Ryuta Maekawa, Hideki Muto, Minoru Hatayama, Jun Aruga   +3 more
doaj   +1 more source

Detection and isolation of the erythropoietin receptor using biotinylated erythropoietin [PDF]

Blood, 1990
Abstract Procedures have been developed to label human erythropoietin (Ep) with biotin to detect and isolate the Ep-receptor. The labeling method used the abundant carbohydrate groups on Ep and resulted in biologically active biotin-Ep (b-Ep) containing 8 to 10 biotins per Ep molecule.
A W, Wognum, P M, Lansdorp, R K, Humphries, G, Krystal   +3 more
openaire   +3 more sources

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Regulation of cell surface transferrin receptor-2 by iron-dependent cleavage and release of a soluble form

Haematologica, 2015
Transferrin receptor-2 is a transmembrane protein whose expression is restricted to hepatocytes and erythroid cells. Transferrin receptor-2 has a regulatory function in iron homeostasis, since its inactivation causes systemic iron overload.
Alessia Pagani, Maud Vieillevoye, Antonella Nai, Marco Rausa, Meriem Ladli, Catherine Lacombe, Patrick Mayeux, Frédérique Verdier, Clara Camaschella, Laura Silvestri   +9 more
doaj   +1 more source

Activation of multiple Eph receptors on neuronal membranes correlates with the onset of optic neuropathy

Eye and Vision, 2023
Background Optic neuropathy is a major cause of irreversible blindness, yet the molecular determinants that contribute to neuronal demise have not been fully elucidated.
Thomas A. Strong, Juan Esquivel, Qikai Wang, Paul J. Ledon, Hua Wang, Gabriel Gaidosh, David Tse, Daniel Pelaez   +7 more
doaj   +1 more source