Results 11 to 20 of about 19,757 (238)

EFFECT OF ERYTHROPOIETIN ON CYTOKINE PRODUCTION BY STEM CELLS

Медицинская иммунология, 2019
Erythropoietin (EPO) is mainly used to stimulate erythropoiesis. Its cytoprotective effects upon other cells of the human body and animals were recently shown, in particular, anti-apoptotic effect was observed.
A. P. Lykov, M. A. Surovtseva, O. V. Poveshchenko, N. A. Bondarenko, I. I. Kim, A. M. Chernyvski, A. V. Fomichev   +6 more
doaj   +1 more source

Erythropoietin receptor and hematological disease [PDF]

American Journal of Hematology, 1999
This review will discuss evidence for the role of the erythropoietin (Epo) receptor in the development of erythrocytosis and other hematological disorders. The possible causative role of mutations of other genes in the pathogenesis of idiopathic erythrocytosis will be considered. Polycythemia vera (PV) is a myeloproliferative disorder that is caused by
McMullin, Mary Frances, Percy, M.J.
openaire   +2 more sources

Second-generation non-hematopoietic erythropoietin-derived peptide for neuroprotection

Redox Biology, 2022
Erythropoietin (EPO) is a well-known erythropoietic cytokine having a tissue-protective effect in various tissues against hypoxic stress, including the brain. Thus, its recombinants may function as neuroprotective compounds. However, despite considerable
Bongki Cho, Seung-Jun Yoo, So Yeon Kim, Chang-Hun Lee, Yun-Il Lee, Seong-Ryong Lee, Cheil Moon   +6 more
doaj   +1 more source

Glycosylation of the murine erythropoietin receptor [PDF]

FEBS Letters, 1990
Murine erythropoietin‐responsive Rauscher Red 5‐1.5 cells were used to determine the contribution of glycosylation to the size and function of the erythropoietin receptor. The half life of the receptors was determined to be 4 h. The number of receptors was not significantly decreased in cells treated for 48 h with inhibitors of glycosylation ...
Mayeux, P., Casadevall, N., Muller, O., Lacombe, C.   +3 more
openaire   +2 more sources

Macrophages as novel target cells for erythropoietin

Haematologica, 2010
Background Our original demonstration of immunomodulatory effects of erythropoietin in multiple myeloma led us to the search for the cells in the immune system that are direct targets for erythropoietin.
Lilach Lifshitz, Galit Tabak, Max Gassmann, Moshe Mittelman, Drorit Neumann   +4 more
doaj   +1 more source

Anaemia in heart failure patients, associated with angiotensin – Renin – aldosterone system altering medications

Heart Views, 2021
Heart failure (HF) remains one of the most common diseases and one of the major causes of death worldwide. HF is often associated with other chronic diseases, most commonly with anemia.
Neda Jonaitiene, Grytė Ramantauskaitė, Jolanta Laukaitienė   +2 more
doaj   +1 more source

Possible erythropoietin pharmacotherapeutic targets on painful diabetic neuropathy in rats [PDF]

Anais da Academia Brasileira de Ciências
Erythropoietin is a renal cytokine involved in regulating hematopoiesis. Current evidence indicates that erythropoietin exerts pleiotropic effects in animal models.
SAMUEL SUAREZ-MENDEZ, DEYSI Y. BERMÚDEZ-OCAÑA   +1 more
doaj   +1 more source

Structure of the Erythropoietin Receptor

Experimental Biology and Medicine, 1994
Despite extensive studies, the structure of the erythropoietin receptor remains little understood. cDNAs encoding the human and murine erythropoietin receptors have been cloned and the structure of these proteins is discussed. Although the proteins encoded by these cDNAs play key roles in erythropoietin binding and in erythropoietin signal transduction,
P, Mayeux, S, Pallu, S, Gobert, C, Lacombe, S, Gisselbrecht   +4 more
openaire   +2 more sources

Cell-specific targeting of lentiviral vectors mediated by fusion proteins derived from Sindbis virus, vesicular stomatitis virus, or avian sarcoma/leukosis virus

Retrovirology, 2010
Background The ability to efficiently and selectively target gene delivery vectors to specific cell types in vitro and in vivo remains one of the formidable challenges in gene therapy.
Marino Michael P, Bialkowska Agnieszka, Kutner Robert H, Zhang Xian-Yang, Klimstra William B, Reiser Jakob   +5 more
doaj   +1 more source

The Effect of Erythropoietin and Its Derivatives on Ischemic Stroke Therapy: A Comprehensive Review

Frontiers in Pharmacology, 2022
Numerous studies explored the therapeutic effects of erythropoietin (EPO) on neurodegenerative diseases. Few studies provided comprehensive and latest knowledge of EPO treatment for ischemic stroke.
Yuanyuan Ma, Zhiyuan Zhou, Guo-Yuan Yang, Jing Ding, Xin Wang, Xin Wang   +5 more
doaj   +1 more source