Results 61 to 70 of about 577,108 (265)

C-FGF23 peptide alleviates hypoferremia during acute inflammation

Haematologica, 2020
Hypoferremia results as an acute phase response to infection and inflammation aiming to reduce iron availability to pathogens. Activation of toll-like receptors (TLRs), the key sensors of the innate immune system, induces hypoferremia mainly through the
Rafiou Agoro, Min Young Park, Carole Le Henaff, Stanislovas Jankauskas, Alina Gaias, Gaozhi Chen, Moosa Mohammadi, Despina Sitara   +7 more
doaj   +1 more source

Activation of multiple Eph receptors on neuronal membranes correlates with the onset of optic neuropathy

Eye and Vision, 2023
Background Optic neuropathy is a major cause of irreversible blindness, yet the molecular determinants that contribute to neuronal demise have not been fully elucidated.
Thomas A. Strong, Juan Esquivel, Qikai Wang, Paul J. Ledon, Hua Wang, Gabriel Gaidosh, David Tse, Daniel Pelaez   +7 more
doaj   +1 more source

Erythropoietin receptor response circuits [PDF]

Current Opinion in Hematology, 2010
In 1985-1989, erythropoietin (EPO), its receptor (EPOR), and janus kinase 2 were cloned; established to be essential for definitive erythropoiesis; and initially intensely studied. Recently, new impetus, tools, and model systems have emerged to re-examine EPO/EPOR actions, and are addressed in this review.
Don M, Wojchowski, Pradeep, Sathyanarayana, Arvind, Dev   +2 more
openaire   +2 more sources

Molecular Dynamics‐Guided Sterol Engineering of mRNA‐Lipid Nanoparticles Reprograms Biodistribution and Enhances Spleen‐Selective Immunity

Advanced Science, EarlyView.
Sterol engineering enables precise control of mRNA lipid nanoparticles by tuning membrane organization. Replacing cholesterol with bile acid‐derived sterols redirects protein expression from the liver to the spleen. Notably, CA‐20 LNP enhances antigen‐specific immune responses while exhibiting a favorable safety profile, highlighting sterols as a ...
Sanghyuk Jeon, Seo‐Hyeon Bae, Jungyong Ji, Jisun Lee, Hosam Choi, Min‐Ho Kang, Sang‐In Park, Hyemin Kim, Nakyung Lee, Hajin Lee, Seonghoon Kim, Jungmin Kim, Subin Yoon, Seonghyun Lee, Seongje Cho, Dahyeon Ha, Ayoung Oh, Sohee Jo, Huijeong Choi, Yeeun Lee, Sowon Lee, Hyo‐Jung Park, Gitak Nam, Jisu Shin, Yujin Kang, Wonpil Im, Kiyoun Lee, Jae‐Hwan Nam   +27 more
wiley   +1 more source

Recruitment of endogenous progenitor cells by erythropoietin loaded particles for in situ cartilage regeneration

Bioactive Materials, 2020
Cartilage injury affects millions of people throughout the world, and at this time there is no cure. While transplantation of stem cells has shown some success in the treatment of injured cartilage, such treatment is limited by limited cell sources and ...
Amirhossein Hakamivala, Shuxin li, Kayti Robinson, YiHui Huang, Shuai Yu, Baohong Yuan, Joseph Borrelli, Jr., Liping Tang   +7 more
doaj   +1 more source

Stanozolol and Danazol Have Different Effects on Hematopoiesis in the Murine Model of Immune-Mediated Bone Marrow Failure

Frontiers in Medicine, 2021
Background: Stanozolol and danazol are widely used in the treatment of aplastic anemia; however, their mechanisms of action are unclear.Methods: Bone marrow mononuclear cells from 10 patients newly diagnosed with aplastic anemia and 10 healthy volunteers
Hongmin Li, Zhangbiao Long, Tao Wang, Bing Han   +3 more
doaj   +1 more source

Context‐Dependent Inverse Association of Glucose–Lipid Metabolic Status With Anemia: Evidence From Multinational Multicohort Analyses

Advanced Science, EarlyView.
Across six multinational cohorts, higher triglyceride–glucose index values are consistently associated with lower prevalent and incident anemia, despite their established adverse cardiometabolic significance. This inverse relationship varies across inflammatory, cardiovascular, and renal contexts, suggesting that glucose–lipid metabolic status carries ...
Guosong Jiang, Xinxing Wang, Lianfeng Xie, Wenna Ding, Yingyong Yin, Mei Yao, Zhibo Cui, Kaiqiang Tang, Lijie Zhong, Zhi Wang, Jia Wang, Lei Lei, Xiaoxiao Qu, Chi‐E. Qiu   +13 more
wiley   +1 more source

Anemia and erythropoietin in heart failure [PDF]

, 2005
Na een hartinfact krijgen veel patiënten te maken met hartfalen; een verminderde pompfunctie van het hart. Peter van der Meer ontdekte dat EPO de hartfunctie van patiënten kan verbeteren.
Meer, Peter van der,, Meer, Peter van der   +1 more
core   +1 more source

Detection and isolation of the erythropoietin receptor using biotinylated erythropoietin [PDF]

Blood, 1990
Abstract Procedures have been developed to label human erythropoietin (Ep) with biotin to detect and isolate the Ep-receptor. The labeling method used the abundant carbohydrate groups on Ep and resulted in biologically active biotin-Ep (b-Ep) containing 8 to 10 biotins per Ep molecule.
A W, Wognum, P M, Lansdorp, R K, Humphries, G, Krystal   +3 more
openaire   +3 more sources

Symmetric signaling by an asymmetric 1 erythropoietin : 2 erythropoietin receptor complex [PDF]

, 2008
Thesis (M. Eng.)--Massachusetts Institute of Technology, Biological Engineering Division, 2008.Includes bibliographical references (p. 43-46).One erythropoietin molecule binds asymmetrically to two identical receptor monomers via erythropoietin site 1 ...
Zhang, Yingxin
core   +3 more sources