Results 211 to 220 of about 665,801 (246)

Navigating the Complexity: A Comprehensive Review of GSK‐3 Inhibition in Regenerative Medicine

Medicinal Research Reviews, EarlyView.
ABSTRACT Glycogen synthase kinase‐3 (GSK‐3) is a central regulator of numerous cellular signaling pathways, with critical roles in metabolism, proliferation, differentiation, and tissue regeneration. This review explores the multifaceted effects of pharmacological GSK‐3 inhibition across multiple body districts, focusing on its highly context‐dependent
Davide Schiroli, Alessia Merra, Chiara Marraccini, Lucia Merolle, Graziella Pellegrini, Eleonora Maurizi   +5 more
wiley   +1 more source

Comparative effects of semaglutide tirzepatide and retatrutide on renal fibrosis in UUO and aged mice. [PDF]

iScience
Ding M, Li X, Wei Y, Wang J, Jiao B, Li C, Ma W, Peng Y, Shen J, Yu G, Gao C.   +10 more
europepmc   +1 more source

Therapeutic Interventions for Radiation‐Induced Fibrosis in Head and Neck Cancer Patients: A Systematic Review

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective To review and evaluate treatments for radiation‐induced fibrosis (RIF) following head and neck cancer (HNC) therapy. Data sources Medline, Embase.com, Web of Science, and Cochrane Library. Review Methods A systematic review was conducted on the management of HNC RIF using the Preferred Reporting Items for Systematic Reviews and Meta ...
Pooja D. Reddy, Purva Rumde, Vanessa Helou, Mary L. Klem, Matthew E. Spector, Marci L. Nilsen, Kevin J. Contrera   +6 more
wiley   +1 more source

Microenvironmental Cues That Regulate Cancer Cell Dormancy in Estrogen-Receptor Positive and Triple-Negative Breast Cancer Cell Lines. [PDF]

Cancer Med
Maniar J, Datt P, Dange PP, Kailaje V, Lakhera M, Samarth M, Durve T, Kadam A, Gandhi KA, Gupta S.   +9 more
europepmc   +1 more source

Human Umbilical Cord Mesenchymal Stem Cell–Derived Exosomes Attenuate Renal Fibrosis by Suppressing Fibroblast Activation via the INHBA/PI3K/AKT Pathway

Pediatric Discovery, EarlyView.
MSC‐Exo derived from human umbilical cord (HucMSC‐Exo) downregulates INHBA expression, consequently modulating the PI3K/AKT signaling cascade. This regulation attenuates renal fibroblast activation and extracellular matrix deposition, thereby exerting a renoprotective effect against fibrosis.
Meiling Chen, Chenxi Jia, Zhuocheng Shi, Bianan Zhu, Yihang Yu, Xing Liu, Feng Liu, Jianwei Chen, Tao Xu, Yuanyuan Zhang, Deying Zhang, Guanghui Wei   +11 more
wiley   +1 more source

Glycosylated Fibronectin in Fetal Growth Restriction: An Emerging Biomarker of Placental Dysfunction. [PDF]

Cureus
Karoutsos DI, Stefanidis K, Michala L, Antsaklis P, Mavrogianni D, Asimakopoulos G, Daskalakis G.   +6 more
europepmc   +1 more source

Epigenetic Regulation of Liver Fibrosis: Mechanisms and Therapeutic Implications

Portal Hypertension &Cirrhosis, EarlyView.
This review synthesizes the epigenetic mechanisms—DNA methylation, histone modifications, and non‐coding RNAs—that drive hepatic stellate cell activation and the progression of liver fibrosis. It further evaluates emerging therapeutic strategies targeting these epigenetic regulators, including DNA methyltransferase and histone deacetylase inhibitors ...
Maryam Jadid Tavaf, Mahboobeh Ebrahimi Varkiani, Saeid Abroun, Pedram Asadi‐Sarabi, Shukoofeh Torabi, Elham Rismani, Mohammad Majd Hammour, Andreas K. Nüssler, Massoud Vosough   +8 more
wiley   +1 more source

Discovery of Novel Glycosidase-Derived Cell-Penetrating Peptides Encoded by Human Gut Commensals. [PDF]

ACS Synth Biol
Post SE, Ceisler HS, Lal RG, Singh A, Deen MA, Bonomo LE, Cunic LM, Brito IL.   +7 more
europepmc   +1 more source

From cytokine storm to renal scarring in diabetic kidney disease: Biomarkers, risk stratification, and precision therapeutics

Precision Medical Sciences, EarlyView.
Hyperglycemia‐driven cytokine activation initiates a sustained inflammatory cascade in diabetic kidney disease, promoting cellular injury and fibrogenic signaling. Integrating cytokine‐based biomarkers with risk stratification enables precision therapeutics that target inflammation and fibrosis, ultimately aiming to halt progression from early renal ...
Emmanuel Ifeanyi Obeagu
wiley   +1 more source