Results 91 to 100 of about 18,956 (224)

Decoding the Pathophysiology of Autoimmune Diseases—Mechanism, Triggers, and Nanotherapeutics: A Review

Advanced NanoBiomed Research, Volume 6, Issue 4, April 2026.
This review highlights how autoimmune diseases arise from intertwined immunological, genetic, and environmental factors, emphasizing gut microbiota dysbiosis as a pivotal driver. It outlines emerging nanotechnology‐based strategies—such as liposomes, hydrogels, and polymeric nanoparticles—that enhance targeted drug delivery, minimize systemic toxicity,
Md. Meraj Ansari, Yunhui Min, Eun‐Ju Ko, Doyoung Kwon, Rehan Khan, Young‐Ok Son   +5 more
wiley   +1 more source

Data showing effects of a PI3K-δ inhibitor on neutrophil superoxide production during FPR2 activation and reactivation

Data in Brief, 2020
Reactive oxygen species (ROS) generated by the NADPH oxidase are crucial for antimicrobial host defense and also play a role in the regulation of inflammatory processes.
André Holdfeldt, Martina Sundqvist, Claes Dahlgren, Huamei Forsman   +3 more
doaj   +1 more source

Serum Amyloid A induces toll-like receptor 2-dependent inflammatory cytokine expression and atrophy in C2C12 skeletal muscle myotubes [PDF]

, 2016
Background Skeletal muscle wasting is an important comorbidity of Chronic Obstructive Pulmonary Disease (COPD) and is strongly correlated with morbidity and mortality. Patients who experience frequent acute exacerbations of COPD (AECOPD) have more severe
Anderson, G, Bozinovski, S, Hansen, M, Passey, S, Vlahos, R   +4 more
core   +1 more source

PSAT1 Promotes NSCLC Progression via the De Novo Serine Synthesis Pathway and Represents a Therapeutic Vulnerability

Cancer Medicine, Volume 15, Issue 4, April 2026.
ABSTRACT Background Non‐small cell lung cancer (NSCLC) is a malignant tumor characterized by high morbidity and mortality, as well as metabolic reprogramming. Enhanced serine synthesis plays a crucial role in the aberrant metabolism of NSCLC. Among the three key enzymes involved in serine synthesis, phosphoserine aminotransferase 1 (PSAT1) requires ...
Xijia Zhou, Min Zhao, Yingshu Cao, Xiangyu Zhou, Ke Wang   +4 more
wiley   +1 more source

Walker 256 Tumor Growth Suppression by Crotoxin Involves Formyl Peptide Receptors and Lipoxin A4

Mediators of Inflammation, 2016
We investigated the effects of Crotoxin (CTX), the main toxin of South American rattlesnake (Crotalus durissus terrificus) venom, on Walker 256 tumor growth, the pain symptoms associated (hyperalgesia and allodynia), and participation of endogenous ...
Patrícia Brigatte, Odair Jorge Faiad, Roberta Cornélio Ferreira Nocelli, Richardt G. Landgraf, Mario Sergio Palma, Yara Cury, Rui Curi, Sandra Coccuzzo Sampaio   +7 more
doaj   +1 more source

Mammalian olfactory receptors

Frontiers in Cellular Neuroscience, 2009
Perception of chemical stimuli from the environment is essential to most animals; accordingly, they are equipped with a complex olfactory system capable of receiving a nearly unlimited number of odorous substances and pheromones.
Joerg Fleischer, Heinz Breer, Joerg Strotmann   +2 more
doaj   +1 more source

Resolvin D1 Halts Remote Neuroinflammation and Improves Functional Recovery after Focal Brain Damage Via ALX/FPR2 Receptor-Regulated MicroRNAs [PDF]

, 2018
Remote damage is a secondary phenomenon that usually occurs after a primary brain damage in regions that are distant, yet functionally connected, and that is critical for determining the outcomes of several CNS pathologies, including traumatic brain and ...
Besharat, Zein Mersini, Bisicchia, Elisa, Catanzaro, Giuseppina, Chiacchiarini, Martina, Chiurchiù, Valerio, Ferretti, Elisabetta, Leuti, Alessandro, Molinari, Marco, Sasso, Valeria, Viscomi, Maria Teresa   +9 more
core   +1 more source

Oxidized mtDNA Contributes to Pulmonary Inflammation and Fibrosis in Bleomycin‐Induced Lung Injury

MedComm, Volume 7, Issue 4, April 2026.
In this study, we demonstrate that bleomycin induces the release of reactive oxygen species (ROS), resulting in oxidative damage to mitochondrial DNA (mtDNA), which subsequently triggers neutrophil infiltration and M2 macrophage polarization in the lungs of mice. These events ultimately contribute to the development of pulmonary fibrosis. Additionally,
Ye Mao, Xinyu Tian, Jiayuan Ai, Xiaoting Zhou, Yanghong Ni, Dandan Wan, Min Luo, Xiawei Wei   +7 more
wiley   +1 more source

Targeting Endothelial Barrier Dysfunction Caused by Circulating Bacterial and Mitochondrial N-Formyl Peptides With Deformylase

Frontiers in Immunology, 2019
Despite recent advances in our understanding of the mechanisms underlying systemic inflammatory response syndrome (SIRS) and sepsis, the current therapeutic approach to these critically ill patients is centered around supportive care including fluid ...
Patricia Martinez-Quinones, Patricia Martinez-Quinones, Amel Komic, Amel Komic, Cameron G. McCarthy, R. Clinton Webb, Camilla Ferreira Wenceslau   +6 more
doaj   +1 more source

Concepts of GPCR-controlled navigation in the immune system

, 2019
G-protein-coupled receptor (GPCR) signaling is essential for the spatiotemporal control of leukocyte dynamics during immune responses. For efficient navigation through mammalian tissues, most leukocyte types express more than one GPCR on their surface ...
Boneschansker L, Brandt SL, Chan EC, Filippo K, Freedman NJ, Hjorto GM, Hons M, Katakai T, Kitayama J, Lemos C, Ley K, Miyabe Y, Moussavi‐Harami SF, Proudfoot AEI, Purvanov V, Rot A, Scheiermann C, Schwarz J, Sokol CL, Sotsios Y, Steury MD, Takeda A, Thiriot A, Tomhave ED, Wang Y, Yanagihara S, Zhang Y   +26 more
core   +1 more source