Results 71 to 80 of about 9,630 (179)

The N-formyl peptide receptors and the anaphylatoxin C5a receptors: An overview

Biochimie, 2007
Leukocyte recruitment to sites of inflammation and infection is dependent on the presence of a gradient of locally produced chemotactic factors. This review is focused on current knowledge about the activation and regulation of chemoattractant receptors.
Rabiet, Marie-Josèphe, Huet, Emilie, Boulay, François   +2 more
openaire   +4 more sources

Cardioprotective Actions of the Annexin-A1 N-Terminal Peptide, Ac2-26, Against Myocardial Infarction

Frontiers in Pharmacology, 2019
The anti-inflammatory, pro-resolving annexin-A1 protein acts as an endogenous brake against exaggerated cardiac necrosis, inflammation, and fibrosis following myocardial infarction (MI) in vivo.
Cheng Xue Qin, Cheng Xue Qin, Cheng Xue Qin, Sarah Rosli, Minh Deo, Nga Cao, Jesse Walsh, Mitchel Tate, Mitchel Tate, Amy E. Alexander, Daniel Donner, Duncan Horlock, Renming Li, Helen Kiriazis, Man K. S. Lee, Jane E. Bourke, Yuan Yang, Andrew J. Murphy, Xiao-Jun Du, Xiao Ming Gao, Rebecca H. Ritchie, Rebecca H. Ritchie, Rebecca H. Ritchie, Rebecca H. Ritchie   +23 more
doaj   +1 more source

Fragments of viral surface proteins modulate innate immune responses via formyl peptide receptors

iScience
Summary: Formyl peptide receptors (FPRs) are pattern recognition receptors well-known for bacterial pathogen sensing. We here identified activator and inhibitor motifs for FPRs that are present on surface proteins of various viral pathogens.
Heiko Heilmann, Lukas Busch, Celine Buchmann, Islam Mohamed, Adrian Theiß, Sabryna Junker, Stefan Lohse, Bernd Bufe   +7 more
doaj   +1 more source

Solubilization and Display of G Protein-Coupled Receptors on Beads for Real-Time Fluorescence and Flow Cytometric Analysis

BioTechniques, 2000
G protein-coupled receptors (GPCR) and cellular signaling elements are prime targets for drug discovery. Sensitive realtime methods that expand the analytical capabilities for these elements can play significant roles in basic research and drug discovery.
L.A. Sklar, J. Vilven, E. Lynam, D. Neldon, T.A. Bennett, E. Prossnitz   +5 more
doaj   +1 more source

Comparative analysis of formyl peptide receptor 1 and formyl peptide receptor 2 reveals shared and preserved signalling profiles

British Journal of Pharmacology
Background and PurposeThe pattern recognition receptors, formyl peptide receptors, FPR1 and FPR2, are G protein‐coupled receptors that recognize many different pathogen‐ and host‐derived ligands. While FPR1 conveys pro‐inflammatory signals, FPR2 is linked with pro‐resolving outcomes.
Denise Pajonczyk, Merle F. Sternschulte, Oliver Soehnlein, Marcel Bermudez, Carsten A. Raabe, Ursula Rescher   +5 more
openaire   +2 more sources

Lipoxin A4 analogue, BML-111, reduces platelet activation and protects from thrombosis

Thrombosis Journal
Formyl peptide receptors (FPRs) are members of seven transmembrane G protein-coupled receptors superfamily that exhibit different responses based on the nature of stimulating ligand type. FPRs have been shown to be present in platelets and regulate their
Shatha AlOmar, Joanne L Mitchell, Eman AlZahrani   +2 more
doaj   +1 more source

Impact of chemotactic factors and receptors on the cancer immune infiltrate: a bioinformatics study revealing homogeneity and heterogeneity among patient cohorts

OncoImmunology, 2018
Multiple soluble factors including proteins (in particular chemokines), non-proteinaceous factors released by dead cells, as well as receptors for such factors (in particular chemokine receptors, formyl peptide receptors and purinergic receptors ...
Gautier Stoll, Jonathan Pol, Vassili Soumelis, Laurence Zitvogel, Guido Kroemer   +4 more
doaj   +1 more source

FPR1: A critical gatekeeper of the heart and brain

Pharmacological Research
G protein-coupled receptors (GPCRs) are currently the most widely focused drug targets in the clinic, exerting their biological functions by binding to chemicals and activating a series of intracellular signaling pathways. Formyl-peptide receptor 1 (FPR1)
Ziyin Zhangsun, Yushu Dong, Jiayou Tang, Zhenxiao Jin, Wangrui Lei, Changyu Wang, Ying Cheng, Baoying Wang, Yang Yang, Huadong Zhao   +9 more
doaj   +1 more source

Differential requirement of formyl peptide receptor 1 in macrophages and neutrophils in the host defense against Mycobacterium tuberculosis Infection

Scientific Reports
Formyl peptide receptors (FPR), part of the G-protein coupled receptor superfamily, are pivotal in directing phagocyte migration towards chemotactic signals from bacteria and host tissues.
Tanvir Noor Nafiz, Poornima Sankar, Lokesh K. Mishra, Robert P. Rousseau, Mohd Saqib, Selvakumar Subbian, Suraj P. Parihar, Bibhuti B. Mishra   +7 more
doaj   +1 more source

Expression of Formyl-peptide Receptors in Human Lung Carcinoma.

Anticancer research, 2015
Formyl-peptide receptors (FPRs) are expressed in several tissues and cell types. The identification of markers involved in cell growth may further allow for molecular profiling of lung cancer. We investigated the possible role of FPRs as molecular markers in several types of lung carcinomas which is the main cause of cancer death worldwide.Tumor tissue
Cattaneo, Fabio, Guerra, Germano, Parisi, Melania, Lucariello, Angela, DE LUCA, Antonio, De Rosa, Nicolina, MAZZARELLA, Gennaro, BIANCO, Andrea, Ammendola, Rosario   +8 more
openaire   +5 more sources