Results 81 to 90 of about 18,956 (224)

Inhibition of formyl peptide receptors improves the outcome in a mouse model of Alzheimer disease

Journal of Neuroinflammation, 2020
Background An important hallmark of Alzheimer’s disease (AD) is the increase of Aβ1-42 burden and its accumulation to senile plaques, leading the reactive gliosis and neurodegeneration.
Nicole Schröder, Anja Schaffrath, Josua A. Welter, Tim Putzka, Angelika Griep, Patrick Ziegler, Elisa Brandt, Sebastian Samer, Michael T. Heneka, Hannes Kaddatz, Jiangshan Zhan, Eugenia Kipp, Thomas Pufe, Simone C. Tauber, Markus Kipp, Lars-Ove Brandenburg   +15 more
doaj   +1 more source

Sequence of Immunological Events During IgE‐Mediated Allergic Reactions to Food

Allergy, EarlyView.
ABSTRACT Food allergies (FA) represent a significant global health burden. Upon allergen re‐exposure, allergic patients exhibit a sequence of symptoms that vary in terms of affected organ systems, severity, time of onset and allergen reactivity thresholds.
N. A. Nagy, D. Schnoegl, V. Houghton, L. O'Mahony, A. F. Santos, E. F. Knol, A. Kuehn, T. Eiwegger   +7 more
wiley   +1 more source

Mitochondrial N‐formyl peptides cause hypotension via formyl peptide receptor activation (1157.6)

The FASEB Journal, 2014
Hypotension is the major pathophysiological characteristic of systemic inflammatory response syndrome (SIRS) and sepsis. Mitochondrial N‐formyl peptides (F‐MIT) are a damage‐associated molecular pattern that activate the innate immune system via the formyl peptide receptor (FPR). We hypothesized that F‐MIT activates FPR and induces hypotension.
openaire   +1 more source

LAT1/SLC7A5‐mediated amino acid uptake is regulated by redox signals triggered by formyl‐peptide receptor 2

The FEBS Journal, EarlyView.
FPR2 activation mediates NOX‐dependent LAT1 expression and, in turn, promotes mTORC1 signaling. Upon stimulation with WKYMVm, the FPR2‐NOX2‐ROS axis upregulates LAT1 via increased c‐Myc phosphorylation and decreased miR‐126. Additionally, it promotes CD98 translocation to the plasma membrane.
Myrhiam Cassese, Chiara Brignola, Stefano Marrone, Gabriella Esposito, Rosario Ammendola, Fabio Cattaneo   +5 more
wiley   +1 more source

Formyl Peptide Receptor 1 Modulates Endothelial Cell Functions by NADPH Oxidase-Dependent VEGFR2 Transactivation [PDF]

, 2018
In the vasculature, NADPH oxidase is the main contributor of reactive oxygen species (ROS) which play a key role in endothelial signalling and functions. We demonstrate that ECV304 cells express p47phox, p67phox, and p22phox subunits of NADPH oxidase, as
Ammendola, Rosario, Castaldo, Martina, Cattaneo, Fabio, Esposito, Gabriella, Faraonio, Raffaella, Parisi, Melania   +5 more
core   +3 more sources

Systemic, Lifestyle and Environmental Modifying Factors in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
A variety of impacting factors in the pathogenesis of periodontitis exist, including systemic, lifestyle, and environmental factors. This review highlights the manifold mechanistic aspects of the link between the pathogenesis of periodontitis, addressing these numerous factors to supplement the long‐standing knowledge of the progression of the disease.
Groeger Sabine Elisabeth, Zhou Yuxi, Yong Jiawen, Wang Lei, Ruf Sabine, Meyle Joerg   +5 more
wiley   +1 more source

Involvement of the α/β Isoform of p38 MAP Kinase in Chemotactic Responses of Human Eosinophils to Eotaxin (CCL11) and RANTES (CCL5) [PDF]

, 2017
Eosinophils are the principal effector cells for allergic inflammation in a variety of diseases, in which they contribute to tissue damage and remodelling processes via the secretion of cytotoxic granular proteins and cytokines.
Dent, G, Hasan, AM
core   +2 more sources

Role of Peptide Backbone Conformation on Biological Activity of Chemotactic Peptides [PDF]

, 1991
To investigate the role of peptide backbone conformation on the biological activity of chemotactic peptides, we synthesized a unique analog of N-formyl-Met-Leu-Phe-OH incorporating the C α,α disubstituted residue, dipropylglycine (Dpg) in place of Leu ...
Bhandary, Krishna K., Dentino, Andrew R., Devine, Michael J., Raj, Periathamby A., Wilson, Mark E.   +4 more
core   +1 more source

Microglia Function in Alzheimer’s Disease [PDF]

, 2012
Contrary to early views, we now know that systemic inflammatory/immune responses transmit to the brain. The microglia (the resident ‘macrophages’ of the brain’s innate immune system) are most responsive, and increasing evidence suggests that they enter a
Egle Solito, Magdalena Sastre
core   +1 more source

Gap Analysis of Metabolic Conversions of Off‐Flavors and Antinutrients in Plant‐Based Substrates

Comprehensive Reviews in Food Science and Food Safety, Volume 25, Issue 3, May 2026.
ABSTRACT To drastically reduce the carbon footprint of the food production chain, a major shift towards alternatives to conventional meat and dairy products is required. The use of plant‐based proteins is a promising route, but it also comes with challenges: Plant‐based proteins often contain antinutritional factors and off‐flavors, which can ...
Robin I. Kuijpers, Isabel O. de Moya Clark, Tomás Cavaco, Vivian Nemanič, Beatrice Tagliabue, Ainhoa Abad Valero, Wiebe M. Wennekers, Mengqiu Zhang, Koen Van Zwet, Sanne Abeln, Sofia Moco, Caroline E. Paul, Halima Mouhib, Richard A. Notebaart, Eddy J. Smid, Bas Teusink, Herwig Bachmann   +16 more
wiley   +1 more source