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Genetic complexity of FSH receptor function
Trends in Endocrinology & Metabolism, 2005The interaction between follicle-stimulating hormone (FSH) and the FSH receptor (FSHR) is essential for normal oogenesis and spermatogenesis. Recently, single-nucleotide polymorphisms (SNPs) have been assigned to the FSHR gene. These give rise to different FSHR haplotypes that modify the action of FSH.
GROMOLL J, SIMONI, Manuela
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Expression of the FSH Receptor in the Testis
1993FSH has multiple and changing roles in the regulation of spermatogenesis. The first function of FSH is to increase the number of Sertoli cells by stimulation of their mitotic activity. During the prepubertal phase of development, FSH is important for the maturation of the Sertoli cells.
Leslie L. Heckert, Michael D. Griswold
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FSH receptors in the bovine corpus luteum
Theriogenology, 1984Binding of follicle stimulating hormone (FSH) to a crude membrane fraction of bovine corpus luteum (CL) has been detected. This binding meets the usual criteria for a receptor based on specificity, time course of reaction and association constant (Ka = 8.5 x 10(10)M(-1)). Physiological studies with CL removed from heifers at specific times after estrus
T.D. Braden, G.D. Niswender, J.G. Manns
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Fish FSH receptors bind LH: How to make the human FSH receptor to be more fishy?
General and Comparative Endocrinology, 2005In mammals, the interactions between glycoprotein hormones and their cognate receptors are highly specific; unintended cross-reactivity under normal physiological conditions has not been observed. The interactions between fish gonadotropins and their receptors, on the other hand, appeared to be less discriminatory.
Henry F. Vischer +3 more
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Journal of Molecular Histology, 2012
The expression of follicle-stimulating hormone (FSH) and its receptor in extrapituitary and non-HPG axis tissues has been demonstrated and their non-reproductive functions in these tissues have been found. However, there have been no reports concerning the expression and function of FSH and its receptor in the cerebellum.
Ya-qun Zhao +7 more
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The expression of follicle-stimulating hormone (FSH) and its receptor in extrapituitary and non-HPG axis tissues has been demonstrated and their non-reproductive functions in these tissues have been found. However, there have been no reports concerning the expression and function of FSH and its receptor in the cerebellum.
Ya-qun Zhao +7 more
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Chemical Biology & Drug Design, 2009
Follicle‐stimulating hormone (FSH) receptor binding inhibitor (FRBI‐8) is a novel octapeptide purified from human ovarian follicular fluid. In vitro, it inhibits the binding of FSH to granulosa cells and in vivo, it induces atresia in developing follicles in rodents.
Smita D. Mahale +6 more
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Follicle‐stimulating hormone (FSH) receptor binding inhibitor (FRBI‐8) is a novel octapeptide purified from human ovarian follicular fluid. In vitro, it inhibits the binding of FSH to granulosa cells and in vivo, it induces atresia in developing follicles in rodents.
Smita D. Mahale +6 more
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Two receptor binding regions of human FSH show sense-antisense similarity to the human FSH receptor
Biochemical and Biophysical Research Communications, 1991The sequences of two receptor binding regions of the beta-subunit of the human follicle-stimulating hormone (hFSH-beta) were compared with the DNA-derived antisense peptide sequence of the hFSH receptor. A striking sense-antisense similarity was established between these receptor binding regions and the hFSH receptor.
Eric W. Roubos, Jerry W. Slootstra
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Functional and clinical consequences of mutations in the FSH receptor
Molecular and Cellular Endocrinology, 1996The follicle-stimulating hormone (FSH) is essential for normal gametogenesis. In females FSH is required for ovarian development and follicle maturation whereas in males FSH determines Sertoli cell number and quantitatively and qualitatively normal spermatogenesis. FSH action is mediated by a G-protein coupled receptor expressed solely in granulosa and
Verena Nordhoff +5 more
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Utilization of in vitro maturation in cases with a FSH receptor mutation
Journal of Assisted Reproduction and Genetics, 2021To identify the FSH receptor (FSHR) variant and efficacy of in vitro maturation (IVM) in a 28-year-old woman with secondary amenorrhea, primary infertility, and ovarian resistance to FSH, and to analyze the genotype-to-phenotype relationship in cases of FSHR mutation for the development of an IVM algorithm for use in patients with gonadotropin ...
Achraf Benammar +9 more
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Regulation of Expression of the FSH Receptor
1993Follicle stimulating hormone (follitropin [FSH]) is a pituitary glycoprotein hormone that is essential for normal reproduction in both male and female mammals. Sertoli cells and granulosa cells are the target cells for the action of FSH in the testes and ovaries, respectively.
Leslie L. Heckert, Michael D. Griswold
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