Results 111 to 120 of about 618,295 (244)

The role of fibroblast growth factors in cell and cancer metabolism

FEBS Letters, EarlyView.
Fibroblast growth factor (FGF) signaling regulates crucial signaling cascades that promote cell proliferation, survival, and metabolism. Therefore, FGFs and their receptors are often dysregulated in human diseases, including cancer, to sustain proliferation and rewire metabolism.
Jessica Price, Chiara Francavilla
wiley   +1 more source

Expression analysis of G Protein-coupled receptors in mouse macrophages [PDF]

, 2008
Background. Monocytes and macrophages express an extensive repertoire of G Protein-Coupled Receptors (GPCRs) that regulate inflammation and immunity.
Glass, Christopher K., Hume, David A., Kellie, Stuart, Lattin, Jane E., Saijo, Kaoru, Schroder, Kate, Su, Andrew I., Sweet, Matthew J., Walker, John R., Wiltshire, Tim, Zhang, Jie   +10 more
core   +3 more sources

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

Uncovering new disease indications for G-protein coupled receptors and their endogenous ligands

BMC Bioinformatics, 2018
Background The Open Targets Platform integrates different data sources in order to facilitate identification of potential therapeutic drug targets to treat human diseases.
Johannes M Freudenberg, Ian Dunham, Philippe Sanseau, Deepak K Rajpal   +3 more
doaj   +1 more source

The IQ‐compete assay for measuring mitochondrial protein import efficiencies in living yeast cells

FEBS Letters, EarlyView.
The efficiency of mitochondrial protein import depends on the properties of the newly synthesized precursor proteins. The Import and de‐Quenching Competition (IQ‐compete) assay is a novel method to monitor the import efficiency of different proteins by fluorescence in living yeast cells.
Yasmin Hoffman, Annika Egeler, Saskia Rödl, Johannes M. Herrmann   +3 more
wiley   +1 more source

Representation Learning for Class C G Protein-Coupled Receptors Classification

Molecules, 2018
G protein-coupled receptors (GPCRs) are integral cell membrane proteins of relevance for pharmacology. The complete tertiary structure including both extracellular and transmembrane domains has not been determined for any member of class C GPCRs.
Raúl Cruz-Barbosa, Erik-German Ramos-Pérez, Jesús Giraldo   +2 more
doaj   +1 more source

Computational Modeling for the Activation Cycle of G-proteins by G-protein-coupled Receptors

, 2010
In this paper, we survey five different computational modeling methods. For comparison, we use the activation cycle of G-proteins that regulate cellular signaling events downstream of G-protein-coupled receptors (GPCRs) as a driving example.
Adriana Compagnoni, Alida Palmisano, Andrew D. Howard, Andrew Phillips, Andrew Phillips, Brian K. Kobilka, Corrado Priami, Federica Ciocchetta, Federica Ciocchetta, Gabriel Ciobanu, J'er^ome Feret, Jane Hillston, Janet D. Robishaw, John W. Pinney, Jos'e M. G. Vilar, Joseph Glavy, Joël Bockaert, Kristen L. Pierce, Louis M. Luttrell, Luca Cardelli, Luca Cardelli, Luca Cardelli, Luca Cardelli, Luca Cardelli, Maciej Koutny, Maria Luisa Guerriero, Mor Peleg, Nan Hao, Ozan Kahramanogullari, Tau M. Yi, Tommy White, William M. Oldham, Yifei Bao, Yifei Bao   +33 more
core   +2 more sources

An expanding range of targets for kynurenine metabolites of tryptophan [PDF]

, 2013
The kynurenine pathway of tryptophan metabolism accounts for most of the tryptophan that is not committed to protein synthesis and includes compounds active in the nervous and immune systems.
Darlington, L. Gail, Stone, Trevor W., Stoy, Nicholas   +2 more
core   +1 more source

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

FEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello, Marcella Maringolo Cristovão, Guilherme Henrique, Vinicius Gonçalves Rodrigues, Caroline Serrano‐Nascimento, Edna Teruko Kimura, Cesar Seigi Fuziwara   +6 more
wiley   +1 more source

Discovery of new G protein-coupled receptors for lipid mediators

Journal of Lipid Research, 2004
Successful sequencing of the human genome has opened a new era in the life sciences and has greatly accelerated biomedical research. Among various research endeavors benefiting from established genomic information, one of the most fruitful areas is the ...
Dong-Soon Im
doaj   +1 more source