Results 41 to 50 of about 479,694 (316)
Method for identification of condition-associated public antigen receptor sequences [PDF]
eLife 2018;7:e33050, 2017 Diverse repertoires of hypervariable immunoglobulin receptors (TCR and BCR) recognize antigens in the adaptive immune system. The development of immunoglobulin receptor repertoire sequencing methods makes it possible to perform repertoire-wide disease association studies of antigen receptor sequences.
arxiv +1 more source
G-Protein–Coupled Receptors in Heart Disease
Circulation Research, 2018 GPCRs (G-protein [guanine nucleotide-binding protein]–coupled receptors) play a central physiological role in the regulation of cardiac function in both health and disease and thus represent one of the largest class of surface receptors targeted by drugs.
Jialu Wang, C. Gareri, H. Rockman
semanticscholar +1 more source
Regulation of Neuromodulator Receptor Efficacy - Implications for Whole-Neuron and Synaptic Plasticity [PDF]
Progress in Neurobiology 72(6), pp 399-415, April 2004, 2004 Membrane receptors for neuromodulators (NM) are highly regulated in their distribution and efficacy - a phenomenon which influences the individual cell's response to central signals of NM release. Even though NM receptor regulation is implicated in the pharmacological action of many drugs, and is also known to be influenced by various environmental ...
arxiv +1 more source
G Protein-Coupled Receptors in Macrophages
Microbiology Spectrum, 2016 ABSTRACTAs the largest receptor gene family in the human genome, with >800 members, the signal-transducing G protein-coupled receptors (GPCRs) play critical roles in nearly all conceivable physiological processes, ranging from the sensing of photons and odorants to metabolic homeostasis and migration of leukocytes.
Hsi-Hsien Lin, Martin Stacey
openaire +3 more sources
Interaction of Prokineticin Receptors with Accessory Proteins
Encyclopedia, 2023 G protein-coupled receptors (GPCRs) are transmembrane proteins that mediate the intracellular pathway of signals not only through heterotrimeric GTP-binding proteins (G proteins) but also through their associations with a variety of additional partner ...
Roberta Lattanzi, Rossella Miele
doaj +1 more source
Mini G protein probes for active G protein–coupled receptors (GPCRs) in live cells
Journal of Biological Chemistry, 2018 G protein–coupled receptors (GPCRs) are key signaling proteins that regulate nearly every aspect of cell function. Studies of GPCRs have benefited greatly from the development of molecular tools to monitor receptor activation and downstream signaling ...
Qingwen Wan +6 more
semanticscholar +1 more source
G-protein-coupled receptor kinases
Trends in Biochemical Sciences, 1991 Rhodopsin kinase and the beta-adrenergic receptor kinase (beta ARK) catalyse the phosphorylation of the activated forms of the G-protein-coupled receptors, rhodopsin and the beta 2-adrenergic receptor (beta 2AR), respectively. The interaction between receptor and kinase is independent of second messengers and appears to involve a multipoint attachment ...
Palczewskl, Krzvsztof +1 more
openaire +4 more sources
Nature Communications, 2022 The yeast Saccharomyces cerevisiae is powerful for studying human G protein-coupled receptors as they can be coupled to its mating pathway. Here the authors engineer baker’s yeast to produce human sterols and show that vertebrate G protein coupled ...
Björn D. M. Bean +12 more
doaj +1 more source
Lysophosphatidic Acid Signaling in Cancer Cells: What Makes LPA So Special?
Cells, 2021 Lysophosphatidic acid (LPA) refers to a family of simple phospholipids that act as ligands for G protein-coupled receptors. While LPA exerts effects throughout the body in normal physiological circumstances, its pathological role in cancer is of great ...
Pravita Balijepalli +2 more
doaj +1 more source
GPCRs in Intracellular Compartments: New Targets for Drug Discovery
Biomolecules, 2022 The architecture of eukaryotic cells is defined by extensive membrane-delimited compartments, which entails separate metabolic processes that would otherwise interfere with each other, leading to functional differences between cells.
Irene Fasciani +7 more
doaj +1 more source