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Cells, 2022 Numerous studies recently showed that the inhibitory neurotransmitter, γ-aminobutyric acid (GABA), can stimulate cerebral angiogenesis and promote neurovascular coupling by activating the ionotropic GABAA receptors on cerebrovascular endothelial cells ...
Sharon Negri +8 more
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Electrophysiology of ionotropic GABA receptors [PDF]
Cellular and Molecular Life Sciences, 2021 AbstractGABAA receptors are ligand-gated chloride channels and ionotropic receptors of GABA, the main inhibitory neurotransmitter in vertebrates. In this review, we discuss the major and diverse roles GABAA receptors play in the regulation of neuronal communication and the functioning of the brain.
Erwan Sallard +2 more
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Characterization of GABA Receptors [PDF]
Current Protocols in Pharmacology, 1998 AbstractDescribed in this unit are ligand‐binding assays for GABAA, GABAB, and the homomeric ρ GABAA(formerly GABAC) receptor recognition sites in brain tissue. Although GABA binding sites are present in peripheral organs, most research is directed toward examining these receptors in the CNS.
Kenneth E. McCarson, S.J. Enna
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Pharmacological Effect of GABA Analogues on GABA-ϱ2 Receptors and Their Subtype Selectivity
Life, 2022 GABAϱ receptors are distinctive GABAergic receptors from other ionotropic GABAA and metabotropic GABAB receptors in their pharmacological, biochemical, and electrophysiological properties. Although GABA-ϱ1 receptors are the most studied in this subfamily,
Moawiah M. Naffaa +3 more
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Functional modifications of acid-sensing ion channels by ligand-gated chloride channels. [PDF]
PLoS ONE, 2011 Together, acid-sensing ion channels (ASICs) and epithelial sodium channels (ENaC) constitute the majority of voltage-independent sodium channels in mammals. ENaC is regulated by a chloride channel, the cystic fibrosis transmembrane conductance regulator (
Xuanmao Chen +3 more
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Axonal Modulation of Striatal Dopamine Release by Local γ-Aminobutyric Acid (GABA) Signalling
Cells, 2021 Striatal dopamine (DA) release is critical for motivated actions and reinforcement learning, and is locally influenced at the level of DA axons by other striatal neurotransmitters. Here, we review a wealth of historical and more recently refined evidence
Bradley M. Roberts +2 more
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Expression of GABAergic receptors in mouse taste receptor cells. [PDF]
PLoS ONE, 2010 Multiple excitatory neurotransmitters have been identified in the mammalian taste transduction, with few studies focused on inhibitory neurotransmitters.
Margaret R Starostik +4 more
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Methods for recording and measuring tonic GABA¬A receptor-mediated inhibition
Frontiers in Neural Circuits, 2013 Tonic inhibitory conductances mediated by GABAA receptors have now been identified and characterised in many different brain regions. Most experimental studies of tonic GABAergic inhibition have been carried out using acute brain slice preparations but ...
Damian eBright, Trevor G. Smart
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Life, 2023 Motoneurons receive thousands of excitatory and inhibitory synapses from descending tracts and primary afferent fibers. The excitability of these neurons must be precisely regulated to respond adequately to the requirements of the environment.
Ximena Delgado-Ramírez +6 more
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BMC Research Notes, 2012 Background GABA receptors are well known as the inhibitory receptors in the central nervous system and are also found in peripheral tissues. We have previously shown that GABA receptors are involved in lung development and fluid homeostasis. However, the
Zhao Chunling +5 more
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