Results 141 to 150 of about 162,039 (295)

Absence seizures: Update on signaling mechanisms and networks

Epilepsia Open, EarlyView.
Abstract Absence seizures (AS) are a hallmark of genetic generalized epilepsies (GGE), characterized by brief episodes of impaired consciousness accompanied by electroencephalographic spike‐and‐wave discharges (SWDs). Traditionally attributed to cortico‐thalamo‐cortical (CTC) dysrhythmia, emerging evidence suggests a more intricate pathophysiological ...
Ozlem Akman, Filiz Onat
wiley   +1 more source

Effects on Breathing of Agonists to μ-opioid or GABA\u3csub\u3eA\u3c/sub\u3e Receptors Dialyzed into the Ventral Respiratory Column of Awake and Sleeping Goats [PDF]

, 2017
Pulmonary ventilation (V̇I) in awake and sleeping goats does not change when antagonists to several excitatory G protein-coupled receptors are dialyzed unilaterally into the ventral respiratory column (VRC).
Burgraff, Nicholas J., Crumley, Emma, Forster, Hubert V., Hodges, Matthew R., Langer, Thomas M., III, Neumueller, Suzanne E., Pan, Lawrence, Talwar, Sawan   +7 more
core   +1 more source

SCN1A gain of function effects in Dravet syndrome: Insights into clinical phenotypes and therapeutic implications

Epilepsia Open, EarlyView.
Abstract A large number of cases with Dravet syndrome (DS) has been attributed to SCN1A loss of function (LOF), whereas SCN1A gain‐of‐function (GOF) causes early infantile developmental and epileptic encephalopathy (EIDEE) and familial hemiplegic migraine 3.
Yoko Kobayashi Takahashi, Kenshiro Tabata, Shimpei Baba, Eri Takeshita, Noriko Sumitomo, Yuko Shimizu‐Motohashi, Takashi Saito, Eiji Nakagawa, Atsushi Ishii, Shinichi Hirose, Mitsuhiro Kato, Naomichi Matsumoto, Hirofumi Komaki, Ken Inoue   +13 more
wiley   +1 more source

Neuroprotective Properties of Wild Mango (Mangifera caloneura Kurz) Leaves on Alleviating Urban Air Pollutant Toxicity: Insights From Transcriptome Analysis of a Human Neuronal Cell Model

Food Frontiers, EarlyView.
ABSTRACT Exposure to urban air pollution, particularly particulate matter (PM), has been correlated with an increased risk of neurodegenerative diseases, notably Alzheimer's and Parkinson's diseases. However, the mechanisms underlying the association between urban air pollution and neurodegenerative diseases remain unclear.
Parinee Kittimongkolsuk, Suporn Sukjamnong, Sakawrat Janpaijit, Panthakarn Rangsinth, Sawarin Chumpolphant, Kamonwan Chaikhong, George Pak‐Heng Leung, Valerie W. Hu, Tewarit Sarachana, Anchalee Prasansuklab, Tewin Tencomnao   +10 more
wiley   +1 more source

Evaluation of Physicochemical and Sensory Properties of Multi‐Nutrient Fortified Flours

Food Safety and Health, EarlyView.
Malnutrition is a prevalent issue in underdeveloped countries, and the development of high‐nutrient foods is a proposed intervention to address this issue. Food fortification is one of the best interventions to address this problem. Wheat–millet multi‐nutrient flour with enhanced nutritional value, such as increased protein, fiber, and antioxidant ...
Gaurav Chaudhary, Monu Kumar, Nisha Swami, Deepti Rani Sehrawat, Anita Rani Sehrawat   +4 more
wiley   +1 more source

Dopamine D-3 receptors regulate GABA(A) receptor function through a phospho-dependent endocytosis mechanism in nucleus accumbens [PDF]

, 2006
The dopamine D-3 receptor, which is highly enriched in nucleus accumbens (NAc), has been suggested to play an important role in reinforcement and reward.
Chen, GJ, Kittler, JT, Moss, SJ, Yan, Z
core  

Research progress of neurovascular units involved in ischemic stroke

Ibrain, EarlyView.
The brain receives less blood when an ischemic stroke develops, which damages neurons and leads to an increased release of Pro‐inflammatory mediators that activate neurovascular unit (NVU). When the tight junctions are broken and the basement membrane is disrupted by matrix metalloproteinases produced by active endothelial and pericellular cells ...
Yu Yang, Hao Tong, Zhuo‐Fan Ye, Zu‐Cai Xu, Tao Tao   +4 more
wiley   +1 more source

Median effective dosage of midazolam oral solution for preschool children in preoperative sedation

Ibrain, EarlyView.
This study aimed to detect median effective dosage (ED50) of midazolam oral solution (MOS) for preschool children in preoperative sedation. Thirty children who were scheduled for elective of the hidden penis correction surgery under general anesthesia in the pediatric surgery department were selected.
Rui Jiang, De‐Chuan Wang, Nan Zhao, Ke An, Yi‐Nan Zhang, Zhao‐Qiong Zhu   +5 more
wiley   +1 more source

Serotonin drives a novel GABAergic synaptic current recorded in rat cerebellar purkinje cells: a lugaro cell to Purkinje cell synapse [PDF]

, 2003
We recorded a novel fast GABAergic synaptic current in cerebellar Purkinje cells in rat brain slices using patch-clamp techniques. Because of a relatively low sensitivity to bicuculline, these currents can be recorded under conditions in which basket ...
Dean, I., Edwards, F.A., Robertson, S.J.
core  

Neuroanatomical and functional correlates in borderline personality disorder: A narrative review

Ibrain, Volume 11, Issue 1, Page 19-31, Spring 2025.
Borderline personality disorder (BPD) is considered a dysfunctional, stable, and pervasive alteration in personality functioning with the inability to adapt to the environment, mental rigidity, and ego‐syntonic, and like all personality disorders is a consistent pattern of inner experience and behavior that deviates markedly from the expectations of ...
Giulio Perrotta
wiley   +1 more source