Results 171 to 180 of about 162,039 (295)

Positron Emission Tomography Imaging in Clinical Trials for Parkinson's Disease: Applications of Metabolic Brain Network Approach

open access: yesMovement Disorders, EarlyView.
ABSTRACT Neuroimaging with positron emission tomography (PET) has been instrumental in elucidating neurobiological mechanisms behind therapeutical trials in Parkinson's disease (PD). A variety of medical and neurosurgical interventions have been evaluated using many radioligands that reveal molecular basis for target engagement and brain responses in ...
Vijay Dhawan   +4 more
wiley   +1 more source

Acetylcholine in the hippocampus: problems and achievements. [PDF]

open access: yesFront Neural Circuits
Dobryakova YV   +3 more
europepmc   +1 more source

The Quinoline Photoremovable Group (PPG) Platform—A Medicinal Chemist's Approach for Photocage Development and Applications

open access: yesMedicinal Research Reviews, EarlyView.
ABSTRACT Photoremovable protecting groups (PPGs) offer a straightforward solution for the temporary inactivation of biologically active substrates and their subsequent controlled release by light irradiation. Their relatively easy design and mode of application have made them useful tools for studying dynamic biological processes in vitro and in vivo ...
Bence Kontra   +3 more
wiley   +1 more source

Molecular Tools to Study and Control Dopaminergic Neurotransmission With Light

open access: yesMedicinal Research Reviews, EarlyView.
ABSTRACT Dopaminergic neurotransmission is involved in several important brain functions, such as motor control, learning, reward‐motivated behavior, and emotions. Dysfunctions of dopaminergic system may lead to the development of various neurological and psychiatric disorders, like Parkinson's disease, schizophrenia, depression, and addictions ...
Galyna Maleeva   +5 more
wiley   +1 more source

An exciting GABA receptor [PDF]

open access: yesNature Reviews Neuroscience, 2003
openaire   +1 more source

TE optimization for J‐difference editing of 2‐hydroxyglutarate at 3T

open access: yesMagnetic Resonance in Medicine, EarlyView.
Abstract Purpose To investigate the TE dependence of the edited 2‐hydroxyglutarate (2HG) signal, its separation from co‐edited glutamate plus glutamine (Glx), and fit accuracy in the presence of nuisance signals using a MEGA‐PRESS sequence. Methods Simulations were performed at TEs 70–160 ms to assess the signal intensity and 2HG‐Glx overlap as a ...
Kimberly L. Chan   +4 more
wiley   +1 more source

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