Results 231 to 240 of about 162,039 (295)

Bumetanide Treatment in 15 Children With Autism: A Randomised Waitlist‐Control Study

Acta Paediatrica, EarlyView.
ABSTRACT Aim Bumetanide, a diuretic, influences neuronal chloride homeostasis and potentially restores GABAergic inhibition and neuronal signalling balance. This mechanism may contribute to improvements in autism‐related symptoms. The present study builds on the preclinical research and on previous clinical research on bumetanide treatment for children
Elisabeth Fernell, Sara Landberg, Carmela Miniscalco, Rosanna Fagerudd, Jakob Åsberg Johnels, Mats Johnson, Nouchine Hadjikhani, Christopher Gillberg   +7 more
wiley   +1 more source

Clinical efficacy and potential mechanisms of acupuncture for Parkinson's disease: the role of GABAergic signaling. [PDF]

Front Neurosci
Lu W, Zhang T, Li M, Zhang J, Liu N, Yang L, Huang G.   +6 more
europepmc   +1 more source

Stereological analysis of cholinergic neurons within bilateral pedunculopontine nuclei in health and when affected by Parkinson's disease

Brain Pathology, EarlyView.
(A) PPN‐cholinergic neurons degenerate during PD. We stereologically counted their rostro‐caudal distribution in post‐mortem PPNs in health versus PD. (Bi) Serial PPN‐containing samples were cholinergic antibody‐DAB stained. (Bii) Only DAB‐stained neurons on green lines and inside the box were counted.
Puneet Kumar Sharma, Steve Gentleman, David Trevor Dexter, Ilse Sanet Pienaar   +3 more
wiley   +1 more source

Foods for Sleep Improvement: A Review of the Potential and Mechanisms Involved. [PDF]

Foods
Fan R, Jia Y, Chen Z, Li S, Qi B, Ma A.
europepmc   +1 more source

Contributions of synaptic energetic dysfunction by microtubule dynamics and microtubule‐based mitochondrial transport disorder to morphine tolerance

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Morphine is among the most powerful analgesic, but its long‐term use can cause tolerance. Synaptic ATP supply is critical for maintaining synaptic transmission. Microtubule‐based mitochondrial transport ensures synaptic energy supply.
Zheng Li, Jie Liu, Jie Ju, Xiaoling Peng, Wei Zhao, Jihao Ren, Xiaoqian Jia, Jihong Wang, Ye Tu, Feng Gao   +9 more
wiley   +1 more source

A Dive Into Cerebellar Dysfunction, Motor Deficits and GABAergic Signaling in Down Syndrome. [PDF]

Cureus
Feely S, Rios Rodriguez M, Shannon A, Young S, Rosales JP, Kaur G.   +5 more
europepmc   +1 more source

Experimental Parkinsonism induced by tetanus toxin injected into basal ganglia

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Local inhibitory circuits and long‐range inhibitory projections within the interconnected basal ganglia nuclei are critical for control of voluntary movement and pathophysiology of different extrapyramidal movement disorders.
Patrik Meglić, Petra Šoštarić, Davor Virag, Ana Knezović, Nikola Habek, Ornella Rossetto, Ivica Matak   +6 more
wiley   +1 more source

The Regulation of γ-Aminobutyric Acid on Antioxidative Defense Response of Pacific Oyster upon High-Temperature Stress. [PDF]

Antioxidants (Basel)
Liu R, Gao L, Zhang X, Ge P, Wang L, Zhou K, Yang C, Wang L, Song L.   +8 more
europepmc   +1 more source

Polypharmacy in mice disrupts left ventricular function and structure and promotes proteome reorganisation in an age‐ and sex‐specific fashion

British Journal of Pharmacology, EarlyView.
Background and Purpose Most older people use polypharmacy (≥5 medications), particularly those with cardiovascular disease. The effects of polypharmacy on the cardiovascular system are not well described. We examined the effect of a chronic polypharmacy regimen on left ventricular (LV) function, structure and proteome in young and old mice of both ...
Trang Tran, Kevin Winardi, Scott P. Levick, Alexander Widiapradja, Gizem Gemikonakli, Susan E. Howlett, Matthew J. McKay, Mark P. Molloy, John Mach, Sarah N. Hilmer   +9 more
wiley   +1 more source

Heterosynaptic Regulation of α2A-Adrenoceptors on Glutamate/GABA Release in the Prefrontal Cortex of Rats. [PDF]

Biomedicines
Wei Y, Jiao Y, He X, Tao X, Li B, Zhang X.   +5 more
europepmc   +1 more source