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The Neurobiology of Gaba Receptors
2006Gamma-aminobutyric acid (GABA) was first identified in 1950 (Roberts 1950; Awapara 1950) in brain extracts of various animal species and was subsequently found to be the principal inhibitory neurotransmitter in the central nervous system (CNS). GABA is synthesized as a result of decarboxylation of glutamic acid and is released by neurons into the ...
SANNA, ENRICO, FOLLESA, PAOLO, BIGGIO G.
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Life Sciences, 2003
A number of important drugs act on GABA(A) receptors, pentameric GABA-gated chloride channels assembled from among 19 known subunits. In trying to discover the roles in the brain of the subunits and their combinations, with the goal of developing more selective drugs, one tool has been to reduce expression of the subunits and examine the functional ...
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A number of important drugs act on GABA(A) receptors, pentameric GABA-gated chloride channels assembled from among 19 known subunits. In trying to discover the roles in the brain of the subunits and their combinations, with the goal of developing more selective drugs, one tool has been to reduce expression of the subunits and examine the functional ...
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Neurochemical Research, 1978
Physiologic-pharmacologic studies in vivo and with tissue cultures have revealed that synaptic GABA receptors exist in the vertebrate CNS. The GABA antagonist, bicuculline, can be used to detect synaptic GABA receptors in both the presence and absence of Na+, even though GABA binding to cerebral subcellular fractions occurs mainly to transport (uptake)
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Physiologic-pharmacologic studies in vivo and with tissue cultures have revealed that synaptic GABA receptors exist in the vertebrate CNS. The GABA antagonist, bicuculline, can be used to detect synaptic GABA receptors in both the presence and absence of Na+, even though GABA binding to cerebral subcellular fractions occurs mainly to transport (uptake)
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Comparative Biochemistry and Physiology Part C: Comparative Pharmacology, 1990
Comparaison des recepteurs GABA ergiques neuronaux des insectes avec ceux des vertebres apres analyse des liaisons de differents agents ...
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Comparaison des recepteurs GABA ergiques neuronaux des insectes avec ceux des vertebres apres analyse des liaisons de differents agents ...
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Locating GABA in GABA receptor binding sites
Biochemical Society Transactions, 2009The Cys-loop family of ligand-gated ion channels contains both vertebrate and invertebrate members that are activated by GABA (γ-aminobutyric acid). Many of the residues that are critical for ligand binding have been identified in vertebrate GABAA and GABAC receptors, and specific interactions between GABA and some of these residues have been ...
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GABA and GABA receptors in invertebrates
Seminars in Neuroscience, 1991Abstract GABA is the major inhibitory transmitter at invertebrate synapses in both the central and peripheral nervous systems. The receptors for GABA are well characterised electrophysiologically in a wide variety of invertebrate organisms but their biochemical and pharmacological profiles are less well defined. In general invertebrate GABA receptors
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GABA-receptors in peripheral tissues
Life Sciences, 1990Gamma-aminobutyric acid (GABA) and its receptors are found in a wide range of peripheral tissues, including parts of the peripheral nervous system, endocrines, and non-neural tissues such as smooth muscle and the female reproductive system. In all these, both GABAA- and GABAB-receptor types are found, with good evidence for a physiological role in the ...
J, Ong, D I, Kerr
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A diversity of GABA receptors in the retina
Seminars in Cell & Developmental Biology, 1998GABA, a major inhibitory transmitter in the vertebrate retina, plays important roles in processing visual information. There are three functional families of retinal GABA receptors, the ionotropic GABAA and GABAC receptors and the metabotropic GABAB receptor. GABAC receptors are enriched in the retina, compared to other parts of the CNS.
P D, Lukasiewicz, C R, Shields
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Bicuculline and Central GABA Receptors
Nature, 1970WE are unable to accept the implication by Krnjevic and his associates1 that we erred in reporting2 bicuculline to be a relatively specific antagonist of γ-aminobutyric acid (GABA) in the central nervous system of the cat.
D R, Curtis +3 more
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Presynaptic Ionotropic GABA Receptors
2007Following the classical work on presynaptic inhibition in the spinal cord, recent work has revealed an astonishing abundance and diversity of presynaptic ionotropic GABA receptors. While modern techniques allow for detailed studies at the cellular and molecular level in almost all regions of the CNS, our understanding of the function of such receptors ...
Andreas, Draguhn +2 more
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