Magnetic Resonance in Medicine, EarlyView.ABSTRACT Purpose This study investigates the effect of VAPOR water suppression and metabolite cycling on metabolite quantification and macromolecules in proton magnetic resonance spectroscopy. Methods Single‐voxel semi‐LASER spectra (TR/TE = 3000/28 ms) and metabolite‐nulled spectra (macromolecules) were acquired in five healthy subjects in the ...
Dinesh K. Deelchand +1 more
wiley +1 more source
Neuro-Transcriptomic Responses to Polypharmacological Agents in <i>Danio rerio</i>: Implications for Translational Drug Repurposing in Neurodevelopmental Disorders. [PDF]
Brain SciBartkowiak AD, Mooney MR.
europepmc +1 more source
Magnetic Resonance in Medicine, EarlyView.ABSTRACT Purpose Quantification of metabolite concentrations using MRS requires tissue‐dependent signal corrections. Accurate estimation of voxel tissue composition is therefore essential. Commonly used brain tissue segmentation tools differ in their algorithms and implementation, potentially introducing variability in MRS‐derived concentration ...
Jessica Archibald +12 more
wiley +1 more source
GABAergic mechanisms of excitation and hypersynchrony in adult rat hippocampus [PDF]
, 2003 Uusisaari, Marylka
core
Cognitive Stimulation and Activity-Dependent Myelination: Oligodendroglial Mechanisms Linking Neural Activity and Brain Plasticity. [PDF]
Int J Mol SciNeyra Chauca JM +6 more
europepmc +1 more source
GABA+‐Edited Magnetic Resonance Spectroscopy Deep Learning Quality Assessment Framework
Magnetic Resonance in Medicine, EarlyView.ABSTRACT Purpose Motivated by the need to improve GABA+‐edited magnetic resonance spectroscopy (MRS) quality, we developed a three‐module framework to improve transient averaging based on quality. We hypothesized that training a deep learning (DL) model to differentiate spectrum quality could improve transient averaging compared to traditional ...
Hanna Bugler +2 more
wiley +1 more source
Are "GABAergic" Agents Really So Selective for GABA? Implications for Single- versus Multi-Site Hypotheses From Promiscuous Behavior of Anesthetics and Their Molecular Targets In Vitro. [PDF]
Anesth AnalgKale KM, Goldstein PA, Pandit JJ.
europepmc +1 more source
Obesity, EarlyView.This study identifies G protein‐coupled receptor 17 (Gpr17) as a novel regulator of leptin and insulin sensitivity. Using complementary knockout models, we demonstrate that Gpr17 deletion enhances energy expenditure, restores leptin responsiveness, and improves insulin sensitivity, revealing Gpr17 as a potential therapeutic GPCR target for obesity and ...
Xun Sun +8 more
wiley +1 more source
Endothelial GABA protects against aortic dissection by inhibiting endothelial and mitochondrial dysfunction and maintaining vascular homeostasis. [PDF]
Signal Transduct Target TherShao L +9 more
europepmc +1 more source
Identifying knowledge barriers to agroforestry adoption and co‐designing solutions to them
People and Nature, EarlyView.Abstract Compared to monocultures, agroforestry can promote biodiversity, ecosystem functioning and climate resilience, whilst maintaining or enhancing production and profits. Despite this, uptake in temperate regions remains low. Knowledge gaps amongst land managers are a primary barrier to uptake, but little is known about which aspects of ...
Amelia S. C. Hood +7 more
wiley +1 more source