Results 21 to 30 of about 527,566 (280)

Conditional gene deletion reveals functional redundancy of GABAB receptors in peripheral nociceptors in vivo

open access: yesMolecular Pain, 2009
Background γ-aminobutyric acid (GABA) is an important inhibitory neurotransmitter which mainly mediates its effects on neurons via ionotropic (GABAA) and metabotropic (GABAB) receptors.
Bettler Bernhard   +6 more
doaj   +1 more source

Investigating the Role of Loop C Hydrophilic Residue 'T244' in the Binding Site of ρ1 GABAC Receptors via Site Mutation and Partial Agonism. [PDF]

open access: yesPLoS ONE, 2016
The loop C hydrophilic residue, threonine 244 lines the orthosteric binding site of ρ1 GABAC receptors was studied by point mutation into serine, alanine and cysteine, and tested with GABA, some representative partial agonists and antagonists. Thr244 has
Moawiah M Naffaa   +5 more
doaj   +1 more source

Mechanisms of Action, Resistance and Toxicity of Insecticides Targeting GABA Receptors.

open access: yesCurrent Medicinal Chemistry, 2017
BACKGROUND γ-Aminobutyric acid (GABA) receptors play a central role in fast inhibitory neurotransmission in insects. Several classes of insecticides targeting insect GABA-gated chloride channels have been developed.
S. Buckingham   +3 more
semanticscholar   +1 more source

Anaesthetic impairment of immune function is mediated via GABA(A) receptors.

open access: yesPLoS ONE, 2011
BackgroundGABA(A) receptors are members of the Cys-loop family of neurotransmitter receptors, proteins which are responsible for fast synaptic transmission, and are the site of action of wide range of drugs.
Daniel W Wheeler   +15 more
doaj   +1 more source

Azo-propofols: photochromic potentiators of GABA(A) receptors.

open access: yesAngewandte Chemie, 2012
Shine and rise! GABA(A) receptors are ligand-gated chloride ion channels that respond to γ-aminobutyric acid (GABA), which is the major inhibitory neurotransmitter of the mammalian central nervous system.
M. Stein   +7 more
semanticscholar   +1 more source

Stress and GABAAreceptors [PDF]

open access: yesJournal of Neurochemistry, 2010
J. Neurochem.(2010)112, 1115–1130.AbstractGABAAreceptors are sensitive to subtle changes in the environment in both early‐life and adulthood. These neurochemical responses to stress in adulthood are sex‐dependent. Acute stress induces rapid changes in GABAAreceptors in experimental animals, with the direction of the changes varying according to the sex
Kelly J. Skilbeck   +2 more
openaire   +3 more sources

GABA-A and GABA-B Receptors in Filial Imprinting Linked With Opening and Closing of the Sensitive Period in Domestic Chicks (Gallus gallus domesticus)

open access: yesFrontiers in Physiology, 2018
Filial imprinting of domestic chicks has a well-defined sensitive (critical) period lasting in the laboratory from hatching to day 3. It is a typical model to investigate the molecular mechanisms underlying memory formation in early learning. We recently
Naoya Aoki   +7 more
doaj   +1 more source

Exploring the Therapeutic Potential of Gamma-Aminobutyric Acid in Stress and Depressive Disorders through the Gut–Brain Axis

open access: yesBiomedicines, 2023
Research conducted on individuals with depression reveals that major depressive disorders (MDDs) coincide with diminished levels of the inhibitory neurotransmitter γ-aminobutyric acid (GABA) in the brain, as well as modifications in the subunit ...
Timur Liwinski   +3 more
doaj   +1 more source

Intermittent Hypoxia Interferes with Autocrine Effects of GABA on Insulin Secretion in Postnatal Rodents—Implications for Pediatric Obstructive Sleep Apnea

open access: yesChildren, 2022
Gamma-amino butyric acid (GABA) is well known to help elevate pancreatic β cell vitality and insulin levels in blood. GABA works via a coupling with GABA receptors; thus, the concentration of GABAA receptors on the plasma membrane of β cells appears to ...
Eung-Kwon Pae   +2 more
doaj   +1 more source

Molecular basis for the high THIP/gaboxadol sensitivity of extrasynaptic GABA(A) receptors.

open access: yesJournal of Neurophysiology, 2011
Extrasynaptic GABA(A) receptors (eGABARs) allow ambient GABA to tonically regulate neuronal excitability and are implicated as targets for ethanol and anesthetics.
P. Meera, M. Wallner, T. Otis
semanticscholar   +1 more source

Home - About - Disclaimer - Privacy