Results 51 to 60 of about 162,039 (295)
Emerging neurotrophic role of GABAB receptors in neuronal circuit development [PDF]
, 2013 The proper development of highly organized structures in the central nervous system is a complex process during which key events – neurogenesis, migration, growth, differentiation, and synaptogenesis – have to take place in an appropriate manner to ...
Christophe Porcher, Jean-Luc Gaiarsa
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Experimental GABA A Receptor Agonists and Allosteric Modulators for the Treatment of Focal Epilepsy
Journal of Experimental Pharmacology, 2021 Slobodan M Janković,1 Miralem Dješević,2 Snežana V Janković1 1Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia; 2Cardiology Department, Private Policlinic Center Eurofarm, Sarajevo, Bosnia and HercegovinaCorrespondence ...
Janković SM, Dješević M, Janković SV
doaj
Regulation of GABAA Receptors Induced by the Activation of L-Type Voltage-Gated Calcium Channels
Membranes, 2021 GABAA receptors are pentameric ion channels that mediate most synaptic and tonic extrasynaptic inhibitory transmissions in the central nervous system.
María Clara Gravielle
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A photoswitchable GABA receptor channel blocker [PDF]
British Journal of Pharmacology, 2019 Background and PurposeAnion‐selective Cys‐loop receptors (GABA and glycine receptors) provide the main inhibitory drive in the CNS. Both types of receptor operate via chloride‐selective ion channels, though with different kinetics, pharmacological profiles, and localization.
Franck Peiretti +16 more
openaire +6 more sources
Advanced Healthcare Materials, EarlyView.This review highlights recent advances in microfluidic technologies for modeling human aging and age‐related diseases. It explores how organ‐on‐chip platforms improve physiological relevance, enable rejuvenation strategies, facilitate drug screening, detect senescent cells, and identify biomarkers.
Limor Zwi‐Dantsis +5 more
wiley +1 more source
Development of GABAergic and glycinergic transmission in the neonatal rat dorsal horn [PDF]
, 2004 Cutaneous spinal sensory transmission appears to lack inhibitory control in the newborn spinal cord, but the properties of GABAergic and glycinergic synapses in the neonatal dorsal horn have not been characterized.
Baccei, ML, Fitzgerald, M
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Adenovector GAD65 gene delivery into the rat trigeminal ganglion produces orofacial analgesia
Molecular Pain, 2009 Background Our goal is to use gene therapy to alleviate pain by targeting glial cells. In an animal model of facial pain we tested the effect of transfecting the glutamic acid decarboxylase (GAD) gene into satellite glial cells (SGCs) of the trigeminal ...
Lowenstein Pedro +9 more
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Advanced Synthesis &Catalysis, EarlyView.Carbodiimides act as competent electrophilic synthons for the chemoselective addition of lithium mono‐ and di‐halocarbenoids. The transformation is provided through a single synthetic operation—hitherto elusive—halogenated acetamidines. Interestingly, the constitutively tamed electrophilicity of the starting materials is effectively counterbalanced by ...
Davide Castiglione +4 more
wiley +1 more source
Two Amino Acid Residues Contribute to a Cation-π Binding Interaction in the Binding Site of an Insect GABA Receptor [PDF]
, 2011 Cys-loop receptor binding sites characteristically possess an "aromatic box," where several aromatic amino acid residues surround the bound ligand. A cation-π interaction between one of these residues and the natural agonist is common, although the ...
Ashby, Jamie A. +3 more
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A Gut Feeling about GABA: Focus on GABAB receptors
Frontiers in Pharmacology, 2010 Gamma-Aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the body and hence GABA-mediated neurotransmission regulates many physiological functions, including those in the gastrointestinal (GI) tract.
Niall P Hyland, John F Cryan
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