Results 71 to 80 of about 449,457 (314)
Frontiers in Molecular Neuroscience, 2008 Glycine and GABA mediate inhibitory neurotransmission in the spinal cord and central nervous system. The general concept of neurotransmission is now challenged by the contribution of both phasic activation of postsynaptic glycine and GABAA receptors ...
Emilie Muller +3 more
doaj +1 more source
Advanced Science, EarlyView.Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng +8 more
wiley +1 more source
Structure, function, and modulation of GABA(A) receptors [PDF]
, 2012 The GABA(A) receptors are the major inhibitory neurotransmitter receptors in mammalian brain. Each isoform consists of five homologous or identical subunits surrounding a central chloride ion-selective channel gated by GABA.
Sigel, Erwin, Steinmann, Michael E
core +1 more source
Intra-accumbens baclofen, but not muscimol, increases second order instrumental responding for food reward in rats. [PDF]
PLoS ONE, 2012 Stimulation of either GABA(A) or GABA(B) receptors within the nucleus accumbens shell strongly enhances food intake in rats. However the effects of subtype-selective stimulation of GABA receptors on instrumental responses for food reward are less well ...
Kim G T Pulman +2 more
doaj +1 more source
Advanced Science, EarlyView.Nanocellulose, derived from microcrystalline cellulose (MCC) through sulfuric acid hydrolysis or mechanical grinding to produce CNC or CNF, was tested in a rat ICP model. Particularly, CNF improved gut microbiota composition, reduced secondary bile acid metabolism, and restored bile acid homeostasis through modulation of the gut–liver axis.
Muhua Yu +18 more
wiley +1 more source
Dopamine D-3 receptors regulate GABA(A) receptor function through a phospho-dependent endocytosis mechanism in nucleus accumbens [PDF]
, 2006 The dopamine D-3 receptor, which is highly enriched in nucleus accumbens (NAc), has been suggested to play an important role in reinforcement and reward.
Kittler, JT, Chen, GJ, Yan, Z, Moss, SJ
core
Purinergic and muscarinic modulation of the cell cycle and calcium signaling in the chick retinal ventricular zone [PDF]
, 2002 Spontaneous calcium transients occur in the ventricular zone of the chick retina and result from the endogenous release of neurotransmitters in the absence of action potentials.
Catsicas, M. +15 more
core +1 more source
Striatal Neurodegeneration that Mimics Huntington’s Disease Modifies GABA-induced Currents
Brain Sciences, 2018 Huntington’s Disease (HD) is a degenerative disease which produces cognitive and motor disturbances. Treatment with GABAergic agonists improves the behavior and activity of mitochondrial complexes in rodents treated with 3-nitropropionic acid to ...
Jorge Flores-Hernández +5 more
doaj +1 more source
GABA receptors in a state of fear [PDF]
Nature Neuroscience, 2015 Our internal states can color our memories just as powerfully as the external environment. A study finds that hippocampal GABAA receptors and associated microRNAs are important for generating state-dependent contextual fear memories.
Holmes, A., Chen, A.
openaire +3 more sources
mGluR5 in ECCCK to BLA Circuit Modulates Depressive‐Like Phenotypes through CCK Signaling
Advanced Science, EarlyView.Dysregulation of mGluR5 and CCK signaling contributes to major depressive disorder, yet circuit‐level mechanisms remain unclear. Here, the ECCCK→BLA pathway is identified as a critical regulator of affective behavior. mGluR5 modulates synaptic function and CCK signaling within this circuit, controlling stress susceptibility and depressive‐like states ...
Muhammad Asim +4 more
wiley +1 more source