Results 81 to 90 of about 112,577,777 (211)

Pathophysiological role of extrasynaptic GABAA receptors in typical absence epilepsy [PDF]

, 2011
GABA is the principal inhibitory neurotransmitter in the mammalian CNS. It acts via two classes of receptors, the GABAA, a ligand gated ion channel (ionotropic receptor) and the metabotropic G-protein coupled GABAB receptor.
Errington, Adam C., Di Giovanni, Giuseppe, Crunelli, Vincenzo   +2 more
core  

Extrasynaptic glycine receptors of rodent dorsal raphe serotonergic neurons:a sensitive target for ethanol [PDF]

, 2014
Alcohol abuse is a significant medical and social problem. Several neurotransmitter systems are implicated in ethanol's actions, with certain receptors and ion channels emerging as putative targets.
Corteen, Nicole, Mitchell, Elizabeth A., Swinny, Jerome, Elizabeth A Mitchell, Lambert, Jeremy J., Jerome D Swinny, Scott J Greig, Edward P Maguire, Maguire, Edward P., Jeremy J Lambert, Nicole Corteen, Swinny, Jerome D., Delia Belelli, Greig, Scott J., David J K Balfour, Balfour, David J. K., Belelli, Delia   +16 more
core   +1 more source

Fast detection of extrasynaptic GABA with a whole-cell sniffer

Frontiers in Cellular Neuroscience, 2014
Gamma-amino-butyric acid (GABA) is the main inhibitory transmitter of the brain. It operates by binding to specific receptors located both inside and outside synapses.
Rasmus Kordt Christensen, Anders Victor Petersen, Nicole eSchmitt, Jean-François ePerrier   +3 more
doaj   +1 more source

Genetic Downregulation of GABA_B Receptors from Oligodendrocyte Precursor Cells Protects Against Demyelination in the Mouse Spinal Cord

Cells
GABAergic signaling and GABAB receptors play crucial roles in regulating the physiology of oligodendrocyte-lineage cells, including their proliferation, differentiation, and myelination.
Davide Gobbo, Phillip Rieder, Li-Pao Fang, Emeline Buttigieg, Moritz Schablowski, Elisa Damo, Nathalie Bosche, Eleonora Dallorto, Pascal May, Xianshu Bai, Frank Kirchhoff, Anja Scheller   +11 more
doaj   +1 more source

Decreased GABA receptor in the cerebral cortex of epileptic rats: effect of Bacopa monnieri and Bacoside-A

Journal of Biomedical Science, 2012
Abstact Background Gamma amino butyric acid (GABA), the principal inhibitory neurotransmitter in the cerebral cortex, maintains the inhibitory tones that counter balances neuronal excitation. When this balance is perturbed, seizures may ensue. Methods In
Mathew Jobin, Balakrishnan Savitha, Antony Sherin, Abraham Pretty, Paulose CS   +4 more
doaj   +1 more source

Neurally Released GABA Acts via GABAC Receptors to Modulate Ca2+ Transients Evoked by Trains of Synaptic Inputs, but Not Responses Evoked by Single Stimuli, in Myenteric Neurons of Mouse Ileum

Frontiers in Physiology, 2018
γ-Aminobutyric Acid (GABA) and its receptors, GABAA,B,C, are expressed in several locations along the gastrointestinal tract. Nevertheless, a role for GABA in enteric synaptic transmission remains elusive.
Katerina Koussoulas, Mathusi Swaminathan, Candice Fung, Joel C. Bornstein, Jaime P. P. Foong   +4 more
doaj   +1 more source

Probing novel compound classes & a new interacting protein for the Mammalian GАВА(_A) receptor [PDF]

, 2006
y-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the vertebrate brain mediating its fast inhibitory action via GABA(_A) receptors. These receptors are implicated in a number of neurological diseases, making GABA(_A) receptor ligands
Abuhamdah, Sawsan "Mohammad Ali"
core  

Structure, function, and modulation of GABA(A) receptors

, 2012
The GABA(A) receptors are the major inhibitory neurotransmitter receptors in mammalian brain. Each isoform consists of five homologous or identical subunits surrounding a central chloride ion-selective channel gated by GABA.
Sigel, Erwin, Steinmann, Michael E
core   +1 more source

The general anaesthetic etomidate inhibits the excitability of mouse thalamocortical relay neurons by modulating multiple modes of GABA_A receptor-mediated inhibition [PDF]

, 2014
Modulation of thalamocortical (TC) relay neuron function has been implicated in the sedative and hypnotic effects of general anaesthetics. Inhibition of TC neurons is mediated predominantly by a combination of phasic and tonic inhibition, together with a
Herd, Murray B., Lambert, Jeremy J., Delia Belelli, Jeremy J. Lambert, Belelli, Delia, Murray B. Herd   +5 more
core   +1 more source

Identification of GABA receptors in chick retinal pigment epithelium

, 2013
Purpose: The retinal pigment epithelium (RPE) is a multifunctional, monolayer of cells located between the neural retina and the choroicapillaris.
Wang, Xu-Ping, Schmid, Katrina L., Cheng, Zhen-Ying, Liu, Lei   +3 more
core   +1 more source