Results 61 to 70 of about 177,108 (289)
Adenovector GAD65 gene delivery into the rat trigeminal ganglion produces orofacial analgesia
Molecular Pain, 2009 Background Our goal is to use gene therapy to alleviate pain by targeting glial cells. In an animal model of facial pain we tested the effect of transfecting the glutamic acid decarboxylase (GAD) gene into satellite glial cells (SGCs) of the trigeminal ...
Lowenstein Pedro +9 more
doaj +1 more source
Interaction of GABA and Excitatory Amino Acids in the Basolateral Amygdala: Role in Cardiovascular Regulation [PDF]
, 1997 Activation of the amygdala in rats produces cardiovascular changes that include increases in heart rate and arterial pressure as well as behavioral changes characteristic of emotional arousal.
Cook, Jennifer C. +3 more
core +2 more sources
Adult‐Onset Subacute Sclerosing Panencephalitis Presenting With Subacute Cognitive Deficits
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT We describe the case of a 41‐year‐old man diagnosed with adult‐onset subacute sclerosing panencephalitis (SSPE). The patient presented with subacute progressive cognitive deficits and a neuropsychological profile indicating predominant frontoparietal dysfunction. MRI showed only mild parietal‐predominant cerebral atrophy.
Dennis Yeow +4 more
wiley +1 more source
Brain Sciences, 2022 The increasing prevalence of obesity and eating disorders makes identifying neural substrates controlling eating and regulating body weight a priority. Recent studies have highlighted the role of the lateral septum (LS) in eating control mechanisms.
Ivett Gabriella +4 more
doaj +1 more source
Determining the Location of GABA Receptor mRNA Transcripts in \u3cem\u3eDanio rerio\u3c/em\u3e [PDF]
, 2018 -aminobutyric acid (GABA) is a neurotransmitter that has been shown to be present in the inner ear. GABA binds to two classes of GABA receptors (GABARs): GABAARs are pentameric ion channels (isoforms include: 1-6, β 1-3, 1-3, 1-3, , , and ); GABABRs ...
O\u27Keefe, Jack
core +1 more source
Clinically applicable GABA receptor positive allosteric modulators promote ß-cell replication. [PDF]
, 2017 A key goal of diabetes research is to develop treatments to safely promote human ß-cell replication. It has recently become appreciated that activation of γ-aminobutyric acid receptors (GABA-Rs) on ß-cells can promote their survival and replication.
Dang, Hoa +3 more
core +1 more source
Advanced Materials, EarlyView.The study reports a DNA/RNA heteroduplex hydrogel (SeroPTEN‐CG) that undergoes DNase‐mediated hydrogel‐to‐nanogel transition for spinal cord injury therapy by targeting the serotonergic system, combining 5‐hydroxytryptamine (5‐HT)‐mediated excitability restoration to reactivate dormant interneurons with phosphatase and tensin homolog (PTEN)‐targeted ...
Chunlin Li +19 more
wiley +1 more source
A Gut Feeling about GABA: Focus on GABAB receptors
Frontiers in Pharmacology, 2010 Gamma-Aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the body and hence GABA-mediated neurotransmission regulates many physiological functions, including those in the gastrointestinal (GI) tract.
Niall P Hyland, John F Cryan
doaj +1 more source
Advanced Materials Technologies, EarlyView.This review explores the integration of microfluidic technology with organoid systems as an innovative platform for studying menopausea complex multi‐organ condition. By enabling precise simulation of inter‐organ communication and hormone responses, microfluidic organoids offer a physiologically relevant model for investigating menopausal syndrome and ...
Qianyi Zhang +4 more
wiley +1 more source
Activation of GABA(A) receptors inhibits T cell proliferation
PLOS ONE, 2021 Background The major sites for fast synaptic inhibition in the central nervous system (CNS) are ion channels activated by γ-aminobutyric acid (GABA). These receptors are referred as GABA(A) receptors (GABA(A)R). Recent evidence indicates a role of GABA(A)R in modulating the immune response.
Emma L. Sparrow +5 more
openaire +6 more sources