Results 61 to 70 of about 527,566 (280)
Regulation of GABAA Receptors Induced by the Activation of L-Type Voltage-Gated Calcium Channels
Membranes, 2021 GABAA receptors are pentameric ion channels that mediate most synaptic and tonic extrasynaptic inhibitory transmissions in the central nervous system.
María Clara Gravielle
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A photoswitchable GABA receptor channel blocker [PDF]
British Journal of Pharmacology, 2019 Background and PurposeAnion‐selective Cys‐loop receptors (GABA and glycine receptors) provide the main inhibitory drive in the CNS. Both types of receptor operate via chloride‐selective ion channels, though with different kinetics, pharmacological profiles, and localization.
Franck Peiretti +16 more
openaire +6 more sources
Heterointerface‐Modulated Synthetic Synapses Exhibiting Complex Multiscale Plasticity
Advanced Science, EarlyView.An asymmetric dual‐gate heterointerface‐regulated artificial synapse (HRAS) is developed, employing distinct ion concentrations and dielectric coupling to form precise dual‐interface channels. Through lateral modulation, HRAS realizes, for the first time, the intricate interplay of lateral inhibition/enhancement and multi‐level short‐ and long‐term ...
Xingji Liu +14 more
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Striatal Neurodegeneration that Mimics Huntington’s Disease Modifies GABA-induced Currents
Brain Sciences, 2018 Huntington’s Disease (HD) is a degenerative disease which produces cognitive and motor disturbances. Treatment with GABAergic agonists improves the behavior and activity of mitochondrial complexes in rodents treated with 3-nitropropionic acid to ...
Jorge Flores-Hernández +5 more
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Advanced Science, EarlyView.Oral aspirin administration induces intestinal expansion of Lactobacillus murinus and Lactobacillus johnsonii, which suppresses the progression of atherosclerosis. This microbial expansion significantly enhances butyrate production by providing lactate as a metabolic substrate, thereby fostering the growth of butyrate‐producing bacteria. Butyrate plays
Rui Hua +15 more
wiley +1 more source
Frontiers in Neuroscience, 2012 Protein kinases are implicated in neuronal cell functions such as modulation of ion channel function, trafficking and synaptic excitability. Both protein kinase C (PKC) and A (PKA) are involved in regulation of γ-aminobutyric acid type A (GABA-A ...
Sandeep eKumar +7 more
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In intact islets interstitial GABA activates GABA(A) receptors that generate tonic currents in α-cells. [PDF]
PLoS ONE, 2013 In the rat islets γ-aminobutyric acid (GABA) is produced by the β-cells and, at least, the α-cells express the GABA(A) receptors (GABA(A) channels). In this study, we examined in intact islets if the interstitial GABA activated the GABA(A) receptors.
Yang Jin +4 more
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Advanced Science, EarlyView.This work identifies a novel mechanism by which dopamine D1 receptor (DRD1) contributes to the pathogenesis of glucocorticoid (GC)‐associated osteonecrosis of the femoral head (ONFH) through the regulation of osteoblastic apoptosis, indicating that DRD1 serves as a critical mediator of the crosstalk between the nervous and skeletal systems.
Kai Zheng +11 more
wiley +1 more source
Post-synaptic GABAA receptors potentiate transmission by recruiting CaV2 channels to their inputs
Cell Reports, 2023 Summary: We describe a retrograde synaptic signal at the C. elegans GABAergic neuromuscular junction. At this synapse, GABA release is controlled by two voltage-activated calcium channels (UNC-2/CaV2 and EGL-19/CaV1), and muscle responses are mediated by
Jian Zhao +3 more
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Frontiers in Pharmacology, 2020 Histamine/gamma-aminobutyric acid (GABA) neurons of posterior hypothalamus send wide projections to many brain areas and participate in stabilizing the wake state.
Shamsiiat Abdurakhmanova +5 more
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