Results 91 to 100 of about 2,475,949 (282)

Sleep-deprivation induces changes in GABA(B) and mGlu receptor expression and has consequences for synaptic long-term depression. [PDF]

PLoS ONE, 2011
Long term depression (LTD) in the CA1 region of the hippocampus, induced with a 20-Hz, 30 s tetanus to Schaffer collaterals, is enhanced in sleep-deprived (SD) rats.
Ramakrishna Tadavarty, Padmesh S Rajput, Jennifer M Wong, Ujendra Kumar, Bhagavatula R Sastry   +4 more
doaj   +1 more source

Oxytocin Reduces Subjective Fear in Naturalistic Social Contexts via Enhancing Top‐Down Middle Cingulate Amygdala Regulation and Brain‐Wide Fear Representations

Advanced Science, EarlyView.
This double‐blind, placebo‐controlled study demonstrates that intranasal oxytocin reduces subjective fear in immersive, naturalistic social (but not non‐social) contexts. Concomitant fMRI reveals that oxytocin enhances middle cingulate activity and amygdala connectivity while it modulates network‐level connectivity and attenuates reactivity of a brain ...
Kun Fu, Shuyue Xu, Zheng Zhang, Dan Liu, Ting Xu, Yuan Zhang, Feng Zhou, Xiaodong Zhang, Chunmei Lan, Junjie Wang, Lan Wang, Jingxian He, Keith M Kendrick, Bharat Biswal, Dezhong Yao, Zhen Liang, Weihua Zhao, Benjamin Becker   +17 more
wiley   +1 more source

A dynamic role for GABA receptors on the firing pattern of midbrain dopaminergic neurons.

Journal of Neurophysiology, 2010
Dopaminergic neurons are subject to a significant background GABAergic input in vivo. The presence of this GABAergic background might be expected to inhibit dopaminergic neuron firing.
C. Lobb, Charles J. Wilson, C. Paladini
semanticscholar   +1 more source

Activation of Spinal Astrocyte α2A Adrenoceptors Protects Against Sepsis‐Induced Heart Injury Through Inhibition of GABAergic Neuronal Necroptosis

Advanced Science, EarlyView.
The study in this paper found that activating the α2A receptors of astrocytes in the thoracic spinal cord can reduce the release of inflammatory factors, thereby decreasing the necroptosis of GABAergic neurons and consequently alleviating myocardial injury caused by sepsis.
Ruilin He, Bin Wu, Liuhu Han, Mingde Li, Wenli Guo, Jiajing Fu, Bin Mei, Eric R. Gross, Xuesheng Liu, Yao Lu   +9 more
wiley   +1 more source

Ethanol activation of protein kinase A regulates GABA-A receptor subunit expression in the cerebral cortex and contributes to ethanol-induced hypnosis

Frontiers in Neuroscience, 2012
Protein kinases are implicated in neuronal cell functions such as modulation of ion channel function, trafficking and synaptic excitability. Both protein kinase C (PKC) and A (PKA) are involved in regulation of γ-aminobutyric acid type A (GABA-A ...
Sandeep eKumar, Qinglu eRen, Jonathan eBeckley, Todd eO'Buckley, Eduardo eGigante, Jessica eSanterre, David F Werner, A Leslie eMorrow   +7 more
doaj   +1 more source

GABA(A) receptor phospho-dependent modulation is regulated by phospholipase C-related inactive protein type 1, a novel protein phosphatase 1 anchoring protein [PDF]

, 2004
GABA(A) receptors are critical in controlling neuronal activity. Here, we examined the role for phospholipase C-related inactive protein type 1 (PRIP-1), which binds and inactivates protein phosphatase 1alpha (PP1alpha) in facilitating GABA(A) receptor ...
Akaike, N, Ha, SH, Hirata, M, Jang, IS, Jovanovic, JN, Kanematsu, T, Kittler, JT, Moss, SJ, Nakayama, KI, Ryu, SH, Terunuma, M   +10 more
core  

Loss of FKBP5 Affects Neuron Synaptic Plasticity: An Electrophysiology Insight [PDF]

, 2019
FKBP5 (FKBP51) is a glucocorticoid receptor (GR) binding protein, which acts as a co-chaperone of heat shock protein 90 (HSP90) and negatively regulates GR.
Deng, Ran, Dou, Longyu, Liang, Tiebing, Liu, Ming, Qiu, Bin, Ren, Wei, Shou, Weinian, Stewart, Robert B., Wang, Chao, Wang, Jun, Williams, Kent E., Xie, Zhongwen, Xu, Yuxue, Yong, Weidong, Zhao, Zhenwen   +14 more
core   +1 more source

Astrocytic GABA transporter activity modulates excitatory neurotransmission

Nature Communications, 2016
Astrocytes are ideally placed to detect and respond to network activity. They express ionotropic and metabotropic receptors, and can release gliotransmitters.
Kim Boddum, Thomas P. Jensen, Vincent Magloire, U. Kristiansen, D. Rusakov, I. Pavlov, M. Walker   +6 more
semanticscholar   +1 more source

Multiscale Organization of Neural Networks in a 3D Bioprinted Matrix

Advanced Science, EarlyView.
A 3D bioprint model of primary neurons has been engineered with a millimeter‐scale functional neural network, and it recapitulates in vivo transcriptomic features under both normal and disease conditions to the greatest extent. The successful integration of mature neurons and 3D bioprinting signifies a major advance in neuroscience modeling ...
Huiyu Yang, Jiangang Zhang, Yiran Li, Zihan Zhong, Wenhua Li, Haojun Luo, Yanyong Liu, Liujian Ouyang, Zhuoran Jiang, Yuning Sun, Hang Sun, Lulu Liu, Huayu Yang, Yu Wang, Nan Yang, Wenbin Ma, Yilei Mao   +16 more
wiley   +1 more source

In Situ Electrically Resettable Field‐Effect Transistor Biosensors for Continuous and Multiplexed Neurotransmitter Detection

Advanced Science, EarlyView.
The research team integrated a potentiometrically controlled pH electrode with carbon nanotube (CNT) field‐effect transistor (FET) biosensors on a single chip using compatible processes. By employing zonal modification and optimized pH‐sensitive probes, they achieved simultaneous quadruple‐target detection and tenfold reusability under physiological ...
Bo Xiao, Tingxian Li, Xianmao Cao, Yang Zhang, Jianping He, Mengmeng Xiao, Zhiyong Zhang   +6 more
wiley   +1 more source