Results 11 to 20 of about 2,475,949 (282)

Functional modifications of acid-sensing ion channels by ligand-gated chloride channels. [PDF]

PLoS ONE, 2011
Together, acid-sensing ion channels (ASICs) and epithelial sodium channels (ENaC) constitute the majority of voltage-independent sodium channels in mammals. ENaC is regulated by a chloride channel, the cystic fibrosis transmembrane conductance regulator (
Xuanmao Chen, Paul Whissell, Beverley A Orser, John F MacDonald   +3 more
doaj   +1 more source

Gamma‐aminobutyric acid (GABA) can affect physiological processes in preimplantation embryos via GABAA and GABAB receptors

Reproductive Medicine and Biology, 2023
Purpose Several widely used substances (e.g., some therapeutics or food supplements) can act on gamma‐aminobutyric acid (GABA) receptors, and we investigated whether the activation of these receptors could affect the preimplantation embryo.
Veronika Kovaříková, Alexandra Špirková, Zuzana Šefčíková, Jozef Pisko, Laura Kalatová, Juraj Koppel, Dušan Fabian, Štefan Čikoš   +7 more
doaj   +1 more source

The role of GABA in islet function

Frontiers in Endocrinology, 2022
Gamma aminobutyric acid (GABA) is a non-proteinogenic amino acid and neurotransmitter that is produced in the islet at levels as high as in the brain. GABA is synthesized by the enzyme glutamic acid decarboxylase (GAD), of which the 65 kDa isoform (GAD65)
D. W. Hagan, S. M. Ferreira, G. J. Santos, Edward A. Phelps, Leticia Prates, Andrei I Tarasov, Laura Marroqui   +6 more
semanticscholar   +1 more source

Expression of GABAergic receptors in mouse taste receptor cells. [PDF]

PLoS ONE, 2010
Multiple excitatory neurotransmitters have been identified in the mammalian taste transduction, with few studies focused on inhibitory neurotransmitters.
Margaret R Starostik, Michelle R Rebello, Kellie A Cotter, Akos Kulik, Kathryn F Medler   +4 more
doaj   +1 more source

GABA_B Receptors Tonically Inhibit Motoneurons and Neurotransmitter Release from Descending and Primary Afferent Fibers

Life, 2023
Motoneurons receive thousands of excitatory and inhibitory synapses from descending tracts and primary afferent fibers. The excitability of these neurons must be precisely regulated to respond adequately to the requirements of the environment.
Ximena Delgado-Ramírez, Nara S. Alvarado-Cervantes, Natalie Jiménez-Barrios, Guadalupe Raya-Tafolla, Ricardo Felix, Vladimir A. Martínez-Rojas, Rodolfo Delgado-Lezama   +6 more
doaj   +1 more source

Actions of Agonists, Fipronil and Ivermectin on the Predominant In Vivo Splice and Edit Variant (RDLbd, I/V) of the Drosophila GABA Receptor Expressed in Xenopus laevis Oocytes [PDF]

, 2014
Ionotropic GABA receptors are the targets for several classes of insecticides. One of the most widely-studied insect GABA receptors is RDL (resistance to dieldrin), originally isolated from Drosophila melanogaster.
Biggin, P, Buckingham, SD, Lees, K, Musgaard, M, Sattelle, D, Suwanmanee, S   +5 more
core   +8 more sources

Endoplasmic reticulum sorting and kinesin-1 command the targeting of axonal GABAB receptors. [PDF]

PLoS ONE, 2012
In neuronal cells the intracellular trafficking machinery controls the availability of neurotransmitter receptors at the plasma membrane, which is a critical determinant of synaptic strength.
Viviana Valdés, José Ignacio Valenzuela, Daniela A Salas, Matías Jaureguiberry-Bravo, Carolina Otero, Christina Thiede, Christoph F Schmidt, Andrés Couve   +7 more
doaj   +1 more source

GABA_A-ρ Receptors in the CNS: Their Functional, Pharmacological, and Structural Properties in Neurons and Astroglia

Neuroglia, 2023
Gamma-aminobutyric acid (GABA) is known as the main inhibitory transmitter in the central nervous system (CNS), where it hyperpolarizes mature neurons through activation of GABAA receptors, pentameric complexes assembled by combination of subunits (α1–6,
Abraham Rosas-Arellano, Argel Estrada-Mondragón, Ataúlfo Martínez-Torres, Daniel Reyes-Haro   +3 more
doaj   +1 more source

Current Perspective on the Location and Function of Gamma- Aminobutyric Acid (GABA) and its Metabolic Partners in the Kidney. [PDF]

, 2014
Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter located in the mammalian central nervous system, which binds to GABAA and GABAB receptors to mediate its neurological effects.
Dunn, Kadeshia, Kelley, Stephen P., Peppiatt-Wildman, Claire M., Wildman, Scott S.P.   +3 more
core   +1 more source

GABA maintains the proliferation of progenitors in the developing chick ciliary marginal zone and non-pigmented ciliary epithelium.

PLoS ONE, 2012
GABA is more than the main inhibitory neurotransmitter found in the adult CNS. Several studies have shown that GABA regulates the proliferation of progenitor and stem cells.
Henrik Ring, Suresh Kumar Mendu, Shahrzad Shirazi-Fard, Bryndis Birnir, Finn Hallböök   +4 more
doaj   +1 more source