Results 191 to 200 of about 2,530,726 (346)

Morphological Changes in Direct Pathway Striatal Neurons in a Rat Model of Tardive Dyskinesia

Movement Disorders, EarlyView.
Abstract Background Tardive dyskinesia (TD) and drug‐induced parkinsonism (DIP) arise from prolonged dopamine antagonist use. Although D2 receptor hypersensitivity in the indirect pathway is a proposed mechanism, the role of the direct pathway remains unclear.
Hiroki Hikichi, Haruo Nishijima, Fumiaki Mori, Iku Kinoshita, Chieko Suzuki, Koichi Wakabayashi, Masahiko Tomiyama   +6 more
wiley   +1 more source

Computational drug repositioning approach to predict multi-target therapeutics for epilepsy. [PDF]

Sci Rep
Kumar P, Kumar V, Chauhan R, Saini V, Kumar A.   +4 more
europepmc   +1 more source

Light‐Based Molecular Tools to Precisely Monitor and Operate β‐Adrenoceptors

Medicinal Research Reviews, EarlyView.
ABSTRACT β‐Adrenoceptors are important G protein–coupled receptors involved in cardiovascular, metabolic, and neurological regulation. To study their function with high precision, light‐based molecular tools have been developed offering precise spatiotemporal control.
Ignazzitto Maria Tindara, Gómez‐Santacana Xavier, Llebaria Amadeu, Rovira Xavier   +3 more
wiley   +1 more source

Targeting γ-aminobutyric acid pathways in irritable bowel syndrome: bridging central nervous system, enteric dysfunction, and the microbiota-gut-brain axis. [PDF]

Front Pharmacol
Lambiase C, Rettura F, Sciumè GD, Tedeschi R, Grosso A, Cancelli L, Bottari A, Fornai M, Antonioli L, de Bortoli N, Bellini M.   +10 more
europepmc   +1 more source

Distinct activities of GABA agonists at synaptic‐ and extrasynaptic‐type GABAA receptors

Journal of Physiology, 2010
M. Mortensen, B. Ebert, K. Wafford, T. Smart   +3 more
semanticscholar   +1 more source

Simultaneous Detection of GABA and Glycine Using MEGA‐PRESS With TE Optimization at 3T

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose To achieve the simultaneous acquisition of gamma‐aminobutyric acid (GABA) and glycine (Gly) using a MEGA‐PRESS sequence with an optimized TE at 3T. Methods MEGA‐PRESS simulations were performed at TEs 60‐88 ms to determine the optimal TE for Gly detection with minimal myo‐Inositol (mI) overlap and maximal GABA detection sensitivity ...
Justin R. Singer, Kimberly L. Chan
wiley   +1 more source

A dynamic role for GABA receptors on the firing pattern of midbrain dopaminergic neurons.

Journal of Neurophysiology, 2010
C. Lobb, Charles J. Wilson, C. Paladini
semanticscholar   +1 more source

Inter‐Individual Differences in T1, T2, and Proton Density Using Quantitative Synthetic Imaging for 1H‐MRS Quantification

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose Metabolite concentrations can be determined from proton magnetic resonance spectroscopy (1H‐MRS) data using water as an internal reference. This calculation requires tissue‐specific water T1 and T2 relaxation constants and proton density (PD).
Samantha A. Leech, Sarah L. Manske, Paul G. Mullins, Tiffany K. Bell, Ashley D. Harris   +4 more
wiley   +1 more source

Neurotransmitters and Immunity: Molecular Mechanisms, Biological Functions, Diseases, and Potential Therapeutic Targets. [PDF]

MedComm (2020)
Li G, Li F, Tang Y, Guo S, Yao Y, Fang Y, Zhang B, Jiang Y, Wang J, Wu D, Cheng J, Huang Z, Xin Z, Zhang T.   +13 more
europepmc   +1 more source

γ-Aminobutyric acid (GABA) signalling in plants

Cellular and Molecular Life Sciences, 2016
Sunita A. Ramesh, S. Tyerman, Matthew Gilliham, Bo Xu   +3 more
semanticscholar   +1 more source