Results 21 to 30 of about 2,467,434 (333)

Mechanisms of Action, Resistance and Toxicity of Insecticides Targeting GABA Receptors.

Current Medicinal Chemistry, 2017
BACKGROUND γ-Aminobutyric acid (GABA) receptors play a central role in fast inhibitory neurotransmission in insects. Several classes of insecticides targeting insect GABA-gated chloride channels have been developed.
S. Buckingham, M. Ihara, D. Sattelle, K. Matsuda   +3 more
semanticscholar   +1 more source

Structural basis of the activation of a metabotropic GABA receptor

Nature, 2020
Metabotropic γ-aminobutyric acid receptors (GABA B ) are involved in the modulation of synaptic responses in the central nervous system and have been implicated in neuropsychological conditions that range from addiction to psychosis 1 . GABA B belongs to
H. Shaye, A. Ishchenko, J. Lam, G. Han, Li Xue, P. Rondard, J. Pin, V. Katritch, C. Gati, V. Cherezov   +9 more
semanticscholar   +1 more source

Robust photoregulation of GABA(A) receptors by allosteric modulation with a propofol analogue. [PDF]

, 2012
Photochemical switches represent a powerful method for improving pharmacological therapies and controlling cellular physiology. Here we report the photoregulation of GABA(A) receptors (GABA(A)Rs) by a derivative of propofol (2,6-diisopropylphenol), a ...
Bruzik, Karol S, Dellal, Shlomo S, Feng, Feng, Otis, Thomas S, Pawlowski, Michal, Pepperberg, David R, Qian, Haohua, Xie, An, Yue, Lan   +8 more
core   +2 more sources

Axonal Modulation of Striatal Dopamine Release by Local γ-Aminobutyric Acid (GABA) Signalling

Cells, 2021
Striatal dopamine (DA) release is critical for motivated actions and reinforcement learning, and is locally influenced at the level of DA axons by other striatal neurotransmitters. Here, we review a wealth of historical and more recently refined evidence
Bradley M. Roberts, Emanuel F. Lopes, Stephanie J. Cragg   +2 more
doaj   +1 more source

Conditional gene deletion reveals functional redundancy of GABA_B receptors in peripheral nociceptors in vivo

Molecular Pain, 2009
Background γ-aminobutyric acid (GABA) is an important inhibitory neurotransmitter which mainly mediates its effects on neurons via ionotropic (GABAA) and metabotropic (GABAB) receptors.
Bettler Bernhard, Tegeder Imgard, Brugger Stefan, Agarwal Nitin, Gangadharan Vijayan, Kuner Rohini, Kurejova Martina   +6 more
doaj   +1 more source

GABA Receptors: Pharmacological Potential and Pitfalls.

Current pharmaceutical design, 2015
Gamma-amino butyric acid (GABA), the major inhibitory neurotransmitter in the mammalian central nervous system, plays a key role in the regulation of neuronal transmission throughout the brain, affecting numerous physiological and psychological processes.
M. J. Jembrek, J. Vlainić
semanticscholar   +1 more source

New GABA amides activating GABA_A-receptors [PDF]

Beilstein Journal of Organic Chemistry, 2013
We have prepared a series of new and some literature-reported GABA-amides and determined their effect on the activation of GABAA-receptors expressed in CHO cells. Special attention was paid to the purification of the target compounds to remove even traces of GABA contaminations, which may arise from deprotection steps in the synthesis. GABA-amides were
Raster, Peter, Späth, Andreas, Bultakova, Svetlana, Gorostiza Langa, Pablo Ignacio, König, Burkhard, Bregestovski, Piotr   +5 more
openaire   +5 more sources

Anaesthetic impairment of immune function is mediated via GABA(A) receptors.

PLoS ONE, 2011
BackgroundGABA(A) receptors are members of the Cys-loop family of neurotransmitter receptors, proteins which are responsible for fast synaptic transmission, and are the site of action of wide range of drugs.
Daniel W Wheeler, Andrew J Thompson, Federico Corletto, Jill Reckless, Justin C T Loke, Nicolas Lapaque, Andrew J Grant, Pietro Mastroeni, David J Grainger, Claire L Padgett, John A O'Brien, Nigel G A Miller, John Trowsdale, Sarah C R Lummis, David K Menon, John S Beech   +15 more
doaj   +1 more source

GABA-A and GABA-B Receptors in Filial Imprinting Linked With Opening and Closing of the Sensitive Period in Domestic Chicks (Gallus gallus domesticus)

Frontiers in Physiology, 2018
Filial imprinting of domestic chicks has a well-defined sensitive (critical) period lasting in the laboratory from hatching to day 3. It is a typical model to investigate the molecular mechanisms underlying memory formation in early learning. We recently
Naoya Aoki, Shinji Yamaguchi, Toshiyuki Fujita, Chihiro Mori, Chihiro Mori, Eiko Fujita, Toshiya Matsushima, Koichi J. Homma   +7 more
doaj   +1 more source

Investigating the Role of Loop C Hydrophilic Residue 'T244' in the Binding Site of ρ1 GABAC Receptors via Site Mutation and Partial Agonism. [PDF]

PLoS ONE, 2016
The loop C hydrophilic residue, threonine 244 lines the orthosteric binding site of ρ1 GABAC receptors was studied by point mutation into serine, alanine and cysteine, and tested with GABA, some representative partial agonists and antagonists. Thr244 has
Moawiah M Naffaa, Nathan Absalom, V Raja Solomon, Mary Chebib, David E Hibbs, Jane R Hanrahan   +5 more
doaj   +1 more source