Results 41 to 50 of about 2,475,949 (282)

GABA potency at GABAA receptors found in synaptic and extrasynaptic zones

Frontiers in Cellular Neuroscience, 2012
The potency of GABA is vitally important for its primary role in activating GABAA receptors and acting as an inhibitory neurotransmitter. Although numerous laboratories have presented information, directly or indirectly, on GABA potency, it is often ...
Martin eMortensen, Bijal ePatel, Trevor G. Smart   +2 more
doaj   +1 more source

Activation of the Rat α1β2ε GABA_A Receptor by Orthosteric and Allosteric Agonists

Biomolecules, 2022
GABAA receptors are a major contributor to fast inhibitory neurotransmission in the brain. The receptors are activated upon binding the transmitter GABA or allosteric agonists including a number of GABAergic anesthetics and neurosteroids.
Allison L. Germann, Ariel B. Burbridge, Spencer R. Pierce, Gustav Akk   +3 more
doaj   +1 more source

Modulation of the GABAergic pathway for the treatment of fragile X syndrome. [PDF]

, 2014
Fragile X syndrome (FXS) is the most common genetic cause of intellectual disability and the most common single-gene cause of autism. It is caused by mutations on the fragile X mental retardation gene (FMR1) and lack of fragile X mental retardation ...
Hagerman, Randi J, Hare, Emma B, Lozano, Reymundo   +2 more
core   +1 more source

Presynaptically Located CB1 Cannabinoid Receptors Regulate GABA Release from Axon Terminals of Specific Hippocampal Interneurons

Journal of Neuroscience, 1999
To understand the functional significance and mechanisms of action in the CNS of endogenous and exogenous cannabinoids, it is crucial to identify the neural elements that serve as the structural substrate of these actions.
I. Katona, B. Sperlágh, A. Sik, Attila Käfalvi, E. Vizi, K. Mackie, T. F. Freund   +6 more
semanticscholar   +1 more source

Co-operative Effect Between γ-Aminobutyric Acid A Receptors and Central-Type Benzodiazepine Receptors on Amylase Release in Rat Parotid Acinar Cells

Journal of Pharmacological Sciences, 2010
We investigated the inhibitory role of γ-aminobutyric acid A (GABA A ) receptors on amylase release and the evidence for functional coupling with central-type benzodiazepine receptors in rat parotid acinar cells.
Migiwa Okubo, Mitsuru Kawaguchi
doaj   +1 more source

Presynaptic actions of 4-Aminopyridine and γ-aminobutyric acid on rat sympathetic ganglia in vitro [PDF]

, 1980
Responses to bath-applications of 4-aminopyridine (4-AP) and -aminobutyric acid (GABA) were recorded intracellularly from neurones in the rat isolated superior cervical ganglion.
A Nistri, A Tokunaga, B Hue, B Katz, C Nicholson, CL Schauf, DA Brown, DA Brown, DA Brown, DA Brown, DA McAfee, DI Wallis, E Jankowska, E Kato, E Kato, G. ten Bruggencate, H Lundh, H Lundh, H Meves, IG Marshall, JE Heuser, JZ Yeh, JZ Yeh, K Golenhofen, M Lemeignan, M Lemeignan, M. Galvan, NG Bowery, P. Grafe, PR Adams, R Llinás, SY Chiu, T Brismar, T Yanagisawa, W Ulbricht, WC Bowman, WW Douglas   +36 more
core   +1 more source

Interaction of GABA and Excitatory Amino Acids in the Basolateral Amygdala: Role in Cardiovascular Regulation [PDF]

, 1997
Activation of the amygdala in rats produces cardiovascular changes that include increases in heart rate and arterial pressure as well as behavioral changes characteristic of emotional arousal.
Cook, Jennifer C., Gregg, Adam E., Sanders, Brian J., Soltis, Robert P.   +3 more
core   +2 more sources

Control of cortical neuronal migration by glutamate and GABA

Frontiers in Cellular Neuroscience, 2015
Neuronal migration in the cortex is controlled by the paracrine action of the classical neurotransmitters glutamate and GABA. Glutamate controls radial migration of pyramidal neurons by acting primarily on NMDA receptors and regulates tangential ...
Heiko J Luhmann, Werner eKilb, Atsuo eFukuda   +2 more
doaj   +1 more source

Modulation of cell surface GABA(B) receptors by desensitization, trafficking and regulated degradation.

World Journal of Biological Chemsitry, 2012
Inhibitory neurotransmission ensures normal brain function by counteracting and integrating excitatory activity. γ-Aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the mammalian central nervous system, and mediates its effects via two ...
D. Benke, Khaled Zemoura, P. Maier
semanticscholar   +1 more source

Functional Characterization of Native, High-Affinity GABAA Receptors in Human Pancreatic β Cells

EBioMedicine, 2018
In human pancreatic islets, the neurotransmitter γ-aminobutyric acid (GABA) is an extracellular signaling molecule synthesized by and released from the insulin-secreting β cells.
Sergiy V. Korol, Zhe Jin, Yang Jin, Amol K. Bhandage, Anders Tengholm, Nikhil R. Gandasi, Sebastian Barg, Daniel Espes, Per-Ola Carlsson, Derek Laver, Bryndis Birnir   +10 more
doaj   +1 more source