Results 31 to 40 of about 27,278 (203)

The hungry stomach: physiology, disease and drug development opportunities

Frontiers in Pharmacology, 2011
During hunger, a series of high-amplitude contractions of the stomach and small intestine (phase III), which form part of a cycle of quiescence and contractions (known as the migrating motor complex; MMC), play a ‘housekeeping’ role prior to the next ...
Gareth J Sanger, Per M Hellström, Erik eNäslund   +2 more
doaj   +1 more source

Physiopathological Implications of 7TM Receptors [PDF]

, 2010
Seven-transmembrane (7TM) receptors are one of the most important proteins involved in perception of extracellular stimuli and regulation of variety of intracellular signaling pathways.
Cygankiewicz, Adam
core   +1 more source

Ghrelin receptor in two species of anuran amphibian, bullfrog (Rana catesbeiana) and Japanese tree frog (Hyla japonica)

Frontiers in Endocrinology, 2011
We identified cDNA encoding a functional growth hormone secretagogue-receptor 1a (GHS-R1a, ghrelin receptor) in two species of anuran amphibian, bullfrog (Rana catesbeiana) and Japanese tree frog (Hyla japonica). Deduced receptor protein for bullfrog and
Hiroyuki eKaiya, Yasushi eKoizumi, Norifumi eKonno, Kazutoshi eYamamoto, Minoru eUchiyama, Kenji eKangawa, Mikiya eMiyazato   +6 more
doaj   +1 more source

Protective actions of des-acylated ghrelin on brain injury and blood-brain barrier disruption after stroke in mice [PDF]

, 2016
The major ghrelin forms, acylated ghrelin and des-acylated ghrelin, are novel gastrointestinal hormones. Moreover, emerging evidence indicates that these peptides may have other functions including neuro- and vaso-protection.
Andrews, Zane B., Austin, Victoria, Barsby, Tom, Chin, Kai Yee, Ku, Jacqueline M., Miller, Alyson A., Spencer, Sarah J., Taher, Mohammadali, Wong, Connie H.Y.   +8 more
core   +1 more source

Structure and Physiological Actions of Ghrelin

Scientifica, 2013
Ghrelin is a gastric peptide hormone, discovered as being the endogenous ligand of growth hormone secretagogue receptor. Ghrelin is a 28 amino acid peptide presenting a unique n-octanoylation modification on its serine in position 3, catalyzed by ghrelin
Christine Delporte
doaj   +1 more source

Ghrelin regulates proliferation and differentiation of osteoblastic cells [PDF]

, 2005
It has previously been reported that growth hormone secretagogues (GHS) may have a role in the regulation of bone metabolism in animals and humans.
COCCHI, Daniela, GIUSTINA, Andrea, MACCARINELLI, Giuseppina, NETTI C, PITTO M, RAIMONDO F, SIBILIA V, TORSELLO A   +7 more
core   +1 more source

Ghrelin and Its Receptors in Gilthead Sea Bream: Nutritional Regulation

Frontiers in Endocrinology, 2018
Ghrelin is involved in the regulation of growth in vertebrates through controlling different functions, such as feed intake, metabolism, intestinal activity or growth hormone (Gh) secretion.
Miquel Perelló-Amorós, Emilio J. Vélez, Jaume Vela-Albesa, Albert Sánchez-Moya, Natàlia Riera-Heredia, Ida Hedén, Jaume Fernández-Borràs, Josefina Blasco, Josep A. Calduch-Giner, Isabel Navarro, Encarnación Capilla, Elisabeth Jönsson, Jaume Pérez-Sánchez, Joaquim Gutiérrez   +13 more
doaj   +1 more source

Neuropeptide receptors as potential antiepileptic drug targets : focus on the ghrelin axis [PDF]

, 2014
Epilepsy is a very serious neurological disorder which is often underrepresented. Around 50 million individuals worldwide have active epilepsy with recurrent seizures and in spite of the medical advances over the years, 30% of these patients remain as ...
Portelli, Jeanelle
core   +1 more source

Periodontitis and metabolic diseases (diabetes and obesity): Tackling multimorbidity

Periodontology 2000, EarlyView., 2023
Abstract Noncommunicable diseases (NCDs) are multifactorial, long‐term, chronic conditions that represent a burden to health‐care systems worldwide as they can only be controlled rather than cured; hence, they require long‐term care. With the exponential increase in NCDs, the occurrence of individuals presenting with more than one chronic disease is ...
Crystal Marruganti, Jean E. Suvan, Francesco D'Aiuto   +2 more
wiley   +1 more source

Ghrelin receptors in non-mammalian vertebrates

Frontiers in Endocrinology, 2013
The growth hormone secretagogue-receptor (GHS-R) was discovered in humans and pigs in 1996. The endogenous ligand, ghrelin, was discovered three years later, in 1999, and our understanding of the physiological significance of the ghrelin system in ...
Hiroyuki eKaiya, Kenji eKangawa, Mikiya eMiyazato   +2 more
doaj   +1 more source