Results 51 to 60 of about 27,278 (203)

The effect of ghrelin upon the early immune response in lean and obese mice during sepsis. [PDF]

PLoS ONE, 2015
It is well established that obesity-related hormones can have modulatory effects associated with the immune response. Ghrelin, a hormone mainly derived from endocrine cells of the gastric mucosa, regulates appetite, energy expenditure and body weight ...
Daniel Siegl, Emily F Midura, Thorsten Annecke, Peter Conzen, Charles C Caldwell, Johannes Tschoep   +5 more
doaj   +1 more source

Significant role of the truncated Ghrelin Receptor GHS-1Rb in Ghrelin-induced signaling in neurons [PDF]

, 2016
The truncated non-signaling ghrelin receptor GHS-R1b has been suggested to simply exert a dominant negative role in the trafficking and signaling of the full and functional ghrelin receptor GHS-R1a.
Andrews, Antonio Cortés, Bennett, Bonaventura, Carme Lluís, Carriba, Chen, Chow, Ciruela, Cuellar, Damian, David Aguinaga, Della Rocca, Dezaki, Dezaki, Dorn, Edgar Angelats, Enric I. Canela, Estefanía Moreno, Ferré, Gemma Navarro, Guitart, Holst, Hradsky, Jang, Jiang, Josefa Mallol, Kern, Kovacs, Leung, Malagón, Mary, Mason, Mireia Medrano, Peter J. McCormick, Schröder, Sergi Ferré, Silver, Sun, Vicent Casadó, Zimmermann   +40 more
core   +1 more source

Essential Updates 2023/2024: Recent Advances of Multimodal Approach in Patients for Gastric Cancer

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Gastric cancer remains a major global health burden, especially in East Asia. Recent years have brought significant advances in multimodal management, including surgery, perioperative chemotherapy, immunotherapy, and supportive care. This review summarizes key updates from 2023 to 2024, focusing on surgical innovations, perioperative systemic ...
Katsutoshi Shoda, Yoshihiko Kawaguchi, Suguru Maruyama, Daisuke Ichikawa   +3 more
wiley   +1 more source

The Good, the Bad and the Unknown Aspects of Ghrelin in Stress Coping and Stress-Related Psychiatric Disorders

Frontiers in Synaptic Neuroscience, 2020
Ghrelin is a peptide hormone released by specialized X/A cells in the stomach and activated by acylation. Following its secretion, it binds to ghrelin receptors in the periphery to regulate energy balance, but it also acts on the central nervous system ...
Eva Maria Fritz, Nicolas Singewald, Dimitri De Bundel   +2 more
doaj   +1 more source

Ghrelin signalling in AgRP neurons links metabolic state to the sensory regulation of AgRP neural activity

Molecular Metabolism, 2023
Objective: The sensory detection of food and food cues suppresses Agouti related peptide (AgRP) neuronal activity prior to consumption with greatest suppression occurring in response to highly caloric food or interoceptive energy need.
Wang Lok So, Jiachen Hu, Lotus Jeffs, Harry Dempsey, Sarah H. Lockie, Jeffrey M. Zigman, Romana Stark, Alex Reichenbach, Zane B. Andrews   +8 more
doaj   +1 more source

Integrating the inputs that shape pancreatic islet hormone release. [PDF]

, 2019
The pancreatic islet is a complex mini organ composed of a variety of endocrine cells and their support cells, which together tightly control blood glucose homeostasis.
Huising, Mark O, Noguchi, Glyn M
core  

Endocrine factors in the hypothalamic regulation of food intake in females: a review of the physiological roles and interactions of ghrelin, leptin, thyroid hormones, oestrogen and insulin [PDF]

, 2011
Controlling energy homeostasis involves modulating the desire to eat and regulating energy expenditure. The controlling machinery includes a complex interplay of hormones secreted at various peripheral endocrine endpoints, such as the gastrointestinal ...
Bartha, Tibor, Frenyó, Vilmos László, Goszleth, Gréta, Győrffy, Andrea, Kiss, Dávid Sándor, Scalise, Johnson, Trudy, Somogyi, Virág, Zsarnovszky, Attila   +7 more
core   +1 more source

Impact of Ghrelin‐Depleting Gastrectomy on Long‐Term Endocrine and Metabolic Health With a Focus on Skeletal Muscle and Bone Mineral Content

Annals of Gastroenterological Surgery, EarlyView.
This study investigates the long‐term endocrine and metabolic consequences of ghrelin‐depleted gastrectomy, with a focus on skeletal muscle mass and bone mineral content. Sustained reductions in serum desacyl‐ghrelin were linked to lower IGF‐1 levels, resulting in significant loss of muscle and bone.
Hiroki Harada, Takuya Goto, Keishi Yamashita, Hiroyuki Minoura, Kota Okuno, Shohei Fujita, Mikiko Sakuraya, Tadashi Higuchi, Koshi Kumagai, Naoki Hiki   +9 more
wiley   +1 more source

Novel regulator of acylated ghrelin, CF801, reduces weight gain, rebound feeding after a fast, and adiposity in mice

Frontiers in Endocrinology, 2015
Ghrelin is a 28 amino-acid hormonal peptide that is intimately related to the regulation of food intake and body weight. Once secreted, ghrelin binds to the growth hormone secretagogue receptor-1a (GHSR-1a), the only known receptor for ghrelin and is ...
Martin K Wellman, Zachary Robert Patterson, Harry eMackay, Joseph E Darling, Bharath K Mani, Jeffrey eZigman, James L Hougland, Alfonso eAbizaid   +7 more
doaj   +1 more source

Mouse circadian plasma leptin and active ghrelin rhythms under ad libitum and scheduled feeding [PDF]

, 2007
Thesis (M.S.) University of Alaska Fairbanks, 2007Light is the strongest timing cue for the circadian system, but non-photic cues can also entrain the master circadian clock, i.e., suprachiasmatic nuclei (SCN).
Wan, Haiting
core