Results 91 to 100 of about 2,748,395 (254)

Glucagon receptor number and the MHC [PDF]

Nature, 1986
Peer Reviewed ; http://deepblue.lib.umich.edu/bitstream/2027.42/62898/1/323586b0 ...
openaire   +3 more sources

Exercise Ameliorates Endocrine Pancreas Damage Induced by Chronic Cola Drinking in Rats [PDF]

, 2016
Purpose: This study evaluates whether the daily practice of an exercise routine might protect from endocrine pancreas damage in cola drinking rats. Methods: Forty-eight Wistar rats were randomly assigned to 4 groups depending on a) beverage consumption ...
Ambrosio, Giuseppe, Azzato, Francisco, Cao, Gabriel Fernando, Gonzalez, Julian, Milei, Jose, Muller, Maria Angelica, Otero-Losada, Matilde Estela, Ottaviano, Graciela Mabel   +7 more
core   +1 more source

The Novel Dual GLP-1/GIP Receptor Agonist DA-CH5 Is Superior to Single GLP-1 Receptor Agonists in the MPTP Model of Parkinson’s Disease

Journal of Parkinson’s Disease, 2020
Background: Parkinson’s disease (PD) is a progressive neurodegenerative disease for which there is no cure. In a clinical trial, the glucagon-like peptide-1 (GLP-1) receptor agonist exendin-4 has shown good protective effects in PD patients.
Lingyu Zhang, Liping Zhang, Yanwei Li, Lin Li, Josefine Ulrikke Melchiorsen, Mette Rosenkilde, Christian Hölscher   +6 more
doaj   +1 more source

A fresh look at augmenter of liver regeneration in rats. [PDF]

, 1999
Augmenter of liver regeneration (ALR) is a hepatotrophic protein originally identified by bioassay in regenerating rat and canine livers following partial hepatectomy and in the hyperplastic livers of weanling rats, but not in resting adult livers.
Abyss, Armendariz-Borunda, Ascoli, Blomquist, Bucher, Bucher, Bucher, Dallman, Dallman, Davies, DeHemptinne, Earp, Evarts, Fausto, Fausto, Fausto, Francavilla, Francavilla, Francavilla, Francavilla, Francavilla, Francavilla, Francavilla, Francavilla, Francavilla, Gabriel, Gandhi, Gandhi, Geerts, Giorda, Grisham, Hagiya, Hagiya, Harding, Higgins, Hully, Itoh, Koch, LaBrecque, Lambotte, Leffert, Leffert, Makowka, Marchioro, Marchioro, Mars, Masumoto, Mazzaferro, McJunkin, Mead, Meyer, Michalopoulos, Michalopoulos, Naldini, Pause, Rilo, Rubin, Russell, Sakamoto, Sasaki, Schirmacher, Shaw, Siekierka, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Steer, Steiner, Steiner, Subbotin, Teir, Terblanche, Vujanovic, Wang, Wang, Webber, Webber, Yamate, Younger, Zindi   +86 more
core   +1 more source

Robust anti‐obesity and metabolic effects of a dual GLP‐1/glucagon receptor peptide agonist in rodents and non‐human primates

Diabetes, obesity and metabolism, 2016
To characterize the pharmacology of MEDI0382, a peptide dual agonist of glucagon‐like peptide‐1 (GLP‐1) and glucagon receptors.
S. Henderson, A. Konkar, D. Hornigold, James L. Trevaskis, R. Jackson, M. F. Fredin, R. Jansson-Löfmark, Jacqueline Naylor, Alessandra Rossi, M. Bednarek, N. Bhagroo, H. Salari, S. Will, Stephanie N. Oldham, G. Hansen, M. Feigh, T. Klein, J. Grimsby, S. Maguire, L. Jermutus, C. Rondinone, M. Coghlan   +21 more
semanticscholar   +1 more source

Novel skeletal effects of glucagon-like peptide-1 (GLP-1) receptor agonists [PDF]

, 2017
Type 2 diabetes mellitus (T2DM) leads to bone fragility and predisposes to increased risk of fracture, poor bone healing and other skeletal complications.
Chantal Chenu, Guillaume Mabilleau, Iepsen, Iepsen, Marie Pereira   +4 more
core   +5 more sources

FRET Reporter Assays for cAMP and Calcium in a 96-well Format Using Genetically Encoded Biosensors Expressed in Living Cells

Bio-Protocol, 2020
Stimulation of G protein-coupled receptors (GPCR) by hormones and neurotransmitters elicits cellular responses, many of which result from alterations in the concentrations of cytosolic cAMP and Ca2+.
Brandon Milliken, Robert Doyle, George Holz, Oleg Chepurny   +3 more
doaj   +1 more source

Pancreatic exocrine insufficiency after bariatric surgery [PDF]

, 2017
Morbid obesity is a lifelong disease, and all patients require complementary follow-up including nutritional surveillance by a multidisciplinary team after bariatric procedures.
Arnelo, Urban, Haas, Stephan L., Löhr, J. -Matthias, Martin, Lena, Rutkowski, Wiktor, Thorell, Anders, Valente, Roberto, Vujasinovic, Miroslav   +7 more
core   +1 more source

Nonconventional glucagon and GLP-1 receptor agonist and antagonist interplay at the GLP-1 receptor revealed in high-throughput FRET assays for cAMP

Journal of Biological Chemistry, 2019
G protein–coupled receptors (GPCRs) for glucagon (GluR) and glucagon-like peptide-1 (GLP-1R) are normally considered to be highly selective for glucagon and GLP-1, respectively.
O. Chepurny, Minos-Timotheos Matsoukas, G. Liapakis, C. Leech, Brandon T. Milliken, R. Doyle, G. Holz   +6 more
semanticscholar   +1 more source

Potential off-target effects of beta-blockers on gut hormone receptors: In silico study including GUT-DOCK-A web service for small-molecule docking.

PLoS ONE, 2019
The prolonged use of many currently available drugs results in the severe side effect of the disruption of glucose metabolism leading to type 2 diabetes mellitus (T2DM.
Pawel Pasznik, Ewelina Rutkowska, Szymon Niewieczerzal, Judyta Cielecka-Piontek, Dorota Latek   +4 more
doaj   +1 more source