Results 41 to 50 of about 2,748,395 (254)
Frontiers in Cell and Developmental Biology, 2021 Betacellulin (BTC), an epidermal growth factor family, is known to promote β-cell regeneration. Recently, pancreatic α-cells have been highlighted as a source of new β-cells. We investigated the effect of BTC on α-cells.
Young-Sun Lee +7 more
doaj +1 more source
Journal of Biological Chemistry, 2013 Background: Glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and glucagon have important gluco-regulatory actions.
V. Gault +3 more
semanticscholar +1 more source
A Novel Glucagon Receptor Antagonist Inhibits Glucagon-Mediated Biological Effects [PDF]
Diabetes, 2004 Glucagon maintains glucose homeostasis during the fasting state by promoting hepatic gluconeogenesis and glycogenolysis. Hyperglucagonemia and/or an elevated glucagon-to-insulin ratio have been reported in diabetic patients and animals. Antagonizing the glucagon receptor is expected to result in reduced hepatic glucose overproduction, leading to ...
Sajjad A, Qureshi +17 more
openaire +2 more sources
Structure and functional motifs of GCR1, the only plant protein with a GPCR fold? [PDF]
, 2013 Whether GPCRs exist in plants is a fundamental biological question. Interest in deorphanizing new G protein coupled receptors (GPCRs), arises because of their importance in signaling.
Abdalla, Nuradin Y +6 more
core +1 more source
Insulin Secretion Depends on Intra-islet Glucagon Signaling.
Cell Reports, 2018 The intra-islet theory states that glucagon secretion is suppressed when insulin secretion is stimulated, but glucagon's role in intra-islet paracrine regulation is controversial. This study investigated intra-islet functions of glucagon in mice.
B. Svendsen +6 more
semanticscholar +1 more source
Different types of soluble fermentable dietary fibre decrease food intake, body weight gain and adiposity in young adult male rats [PDF]
, 2014 We thank Donna Wallace and the Rowett Animal House staff for the daily care of experimental rats, body weight and food intake measurements and MRI scanning, Vivien Buchan and Donna Henderson of the Rowett Analytical Department for proximate analyses and ...
Adam, Clare L +7 more
core +2 more sources
Does glucagon have a positive inotropic effect in the human heart?
Cardiovascular Diabetology, 2018 Glucagon is considered to exert cardiostimulant effects, most notably the enhancement of heart rate and contractility, due to the stimulation of glucagon receptors associated with Gs protein stimulation which causes adenylyl cyclase activation and the ...
Jesus Hernández-Cascales
doaj +1 more source
Терапевтический архив, 2023 Glucagon-like peptide-1 receptor agonists (arGLP1) are an effective treatment for patients with type 2 diabetes mellitus (T2DM), mainly due to increasing insulin secretion and suppressing glucagon release by stimulating the respective receptors.
Tatiana Y. Demidova +2 more
doaj +1 more source
Constitutive Activity of Glucagon Receptor Mutants [PDF]
Molecular Endocrinology, 1998 Increased constitutive activity has been observed in the PTH receptor in association with naturally occurring mutations of two residues that are conserved between members of the glucagon/vasoactive intestinal peptide/calcitonin 7TM receptor family. Here, the corresponding residues of the glucagon receptor, His178 and Thr352, were probed by mutagenesis.
Hjorth, Siv A. +2 more
openaire +2 more sources
Role of histamine H3 receptor in glucagon‐secreting αTC1.6 cells
FEBS Open Bio, 2015 Pancreatic α‐cells secrete glucagon to maintain energy homeostasis. Although histamine has an important role in energy homeostasis, the expression and function of histamine receptors in pancreatic α‐cells remains unknown.
Tadaho Nakamura +7 more
doaj +1 more source