Results 71 to 80 of about 2,748,395 (254)

δ-Cells: The Neighborhood Watch in the Islet Community

Biology, 2021
Somatostatin-secreting δ-cells have aroused great attention due to their powerful roles in coordination of islet insulin and glucagon secretion and maintenance of glucose homeostasis.
Rui Gao, Tao Yang, Quan Zhang
doaj   +1 more source

Effects of the vasoactive intestinal peptide (VIP) and related peptides on glioblastoma cell growth in vitro [PDF]

, 2003
The growth rate of numerous cancer cell lines is regulated in part by actions of neuropeptides of the vasoactive intestinal peptide (VIP) family, which also includes pituitary adenylate cyclase-activating peptide (PACAP), glucagon, and peptide histidine ...
Alleaume, Céline, Dufès, Christine, Montoni, Alicia, Muller, Jean-Marc, Olivier, Jean-Christophe   +4 more
core   +1 more source

Computational Peptide Design Cotargeting Glucagon and Glucagon-like Peptide-1 Receptors

Journal of Chemical Information and Modeling, 2023
Peptides are sustainable alternatives to conventional therapeutics for G protein-coupled receptor (GPCR) linked disorders, promising biocompatible and tailorable next-generation therapeutics for metabolic disorders including type-2 diabetes, as agonists of the glucagon receptor (GCGR) and the glucagon-like peptide-1 receptor (GLP-1R).
Shubham Vishnoi, Shayon Bhattacharya, Erica M. Walsh, Grace Ilevbare Okoh, Damien Thompson   +4 more
openaire   +3 more sources

Evolution of GCGR family ligand-receptor extensive cross-interaction systems suggests a therapeutic direction for hyperglycemia in mammals

Acta Biochimica et Biophysica Sinica, 2023
Glucose is essential to the physiological processes of vertebrates. Mammalian physiological stability requires a relatively stable blood glucose level (~5 mM), whereas other vertebrates have greater flexibility in
Liu Jian, Wang Xue, Zhang Wenli, Liao Guangneng, Shao Zhenhua, Brosius Juergen, Deng Cheng, Lai Shanshan, Long Enwu   +8 more
doaj   +1 more source

What doesn't kill you makes you stranger: Dipeptidyl peptidase-4 (CD26) proteolysis differentially modulates the activity of many peptide hormones and cytokines generating novel cryptic bioactive ligands [PDF]

, 2019
Dipeptidyl peptidase 4 (DPP4) is an exopeptidase found either on cell surfaces where it is highly regulated in terms of its expression and surface availability (CD26) or in a free/circulating soluble constitutively available and intrinsically active form.
Aguilar-Pérez, Alexandra, Awad, Mohamed E., Eisa, Nada H., Elmansi, Ahmed M., Fulzele, Sadanand, Hamrick, Mark W., Herberg, Samuel, Hill, William D., Hussein, Khaled A., Isales, Carlos M., Kondrikov, Dmitry, McGee-Lawrence, Meghan E., Periyasamy-Thandavan, Sudharsan, Volkman, Brian F.   +13 more
core   +1 more source

Targeting the GPR119/incretin axis: a promising new therapy for metabolic-associated fatty liver disease

Cellular & Molecular Biology Letters, 2021
In the past decade, G protein-coupled receptors have emerged as drug targets, and their physiological and pathological effects have been extensively studied. Among these receptors, GPR119 is expressed in multiple organs, including the liver.
Jianan Zhao, Yu Zhao, Yiyang Hu, Jinghua Peng   +3 more
doaj   +1 more source

Targeting the Incretin/Glucagon System With Triagonists to Treat Diabetes

Endocrine reviews, 2018
Glucagonlike peptide 1 (GLP-1) receptor agonists have been efficacious for the treatment of type 2 diabetes due to their ability to reduce weight and attenuate hyperglycemia. However, the activity of glucagonlike peptide 1 receptor–directed strategies is
M. Capozzi, R. DiMarchi, M. Tschöp, Brian Finan, Jonathan E. Campbell   +4 more
semanticscholar   +1 more source

Clinical perspectives on the use of the GIP/GLP-1 receptor agonist tirzepatide for the treatment of type-2 diabetes and obesity

Frontiers in Endocrinology, 2022
Incretin-based therapies with glucagon-like peptide-1 receptor agonists (GLP-1RA) are already established in the treatment of type 2 diabetes (T2D). The development of novel dual- or triple-receptor agonists that bind to the receptors not only for GLP-1 ...
Baptist Gallwitz
doaj   +1 more source

Expression and function of alpha(v)beta(3) and alpha(v)beta(5) integrins in the developing pancreas: roles in the adhesion and migration of putative endocrine progenitor cells. [PDF]

, 2000
Cell-cell and cell-matrix interactions play a critical role in tissue morphogenesis and in homeostasis of adult tissues. The integrin family of adhesion receptors regulates cellular interactions with the extracellular matrix, which provides three ...
Alpert, Bauer, Beattie, Beattie, Beattie, Blaschuk, Bosco, Brooks, Brooks, Calof, Cheng, Choquet, Cirulli, Cirulli, Cirulli, Clark, Clark, Dahl, DiPersio, Drake, Dudek, Ekblom, Felding-Habermann, Friedlander, George, Giancotti, Gu, Gu, Gullberg, Herrera, Herrera, Hynes, Hynes, Jaffe, Jansson, Jensen, Jones, Kantengwa, Langerhans, Langhofer, Like, Lin, Lombardi, Marchisio, Orci, Orci, Orci, Otonkoski, Otonkoski, Otonkoski, Pelletier, Pictet, Pictet, Pierschbacher, Ricordi, Rouiller, Sandler, Schwartz, Slack, Sonnenberg, Stefan, Strange, Talhouk, Teitelman, Tuch, Von Dorsche, Walker, Watt   +67 more
core   +1 more source

The Effects of Dual GLP-1/GIP Receptor Agonism on Glucagon Secretion—A Review

International Journal of Molecular Sciences, 2019
The gut-derived incretin hormones glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are secreted after meal ingestion and work in concert to promote postprandial insulin secretion. Furthermore, GLP-1 inhibits glucagon
David S Mathiesen, J. Bagger, N. Bergmann, A. Lund, M. Christensen, T. Vilsbøll, F. Knop   +6 more
semanticscholar   +1 more source