Results 231 to 240 of about 669,888 (299)

Biography as the Missing Variable in Drug Development: A Case for Bio‐Biographical Mechanistic Profiling

Clinical Pharmacology &Therapeutics, EarlyView.
Most clinical trial failures reflect unmeasured biological heterogeneity. Biography — chronic stress, adversity, trauma, and social isolation—is a neglected source of that heterogeneity, operating through the same molecular pathways drugs engage.
Ralph I. Horwitz
wiley   +1 more source

Glucocorticoid Receptor Signaling: Multilevel Organization, Roles in Fetal Development, and Postnatal Outcomes. [PDF]

Int J Mol Sci
Potapova S, Isakov Y, Tyulkova E, Vetrovoy O.   +3 more
europepmc   +1 more source

Exposure–Response Analysis of Enfortumab Vedotin Plus Pembrolizumab as First‐Line Therapy for Locally Advanced or Metastatic Urothelial Cancer

Clinical Pharmacology &Therapeutics, EarlyView.
Enfortumab vedotin is a nectin‐4‐directed antibody–drug conjugate currently approved in combination with pembrolizumab for the first‐line treatment of locally advanced or metastatic urothelial cancer. Here we describe the exposure–response relationship between enfortumab vedotin exposures and efficacy/safety endpoints in patients who received ≥1 dose ...
Vaishali L. Chudasama, Helen Kastrissios, Hossam Kadry, Daping Zhang, Salaheldin Hamed, Srinivasu Poondru, Souvik Bhattacharya, Russ Wada, Amit Garg, Yen Lin Chia   +9 more
wiley   +1 more source

Investigation of factors influencing intravenous glucocorticoid treatment course in severe acute urticaria: A retrospective study. [PDF]

Medicine (Baltimore)
Wang K, Liao M, Xiong S, Wu X, Zeng Z, You C.   +5 more
europepmc   +1 more source

Stable clocks, rewired rhythms: circadian remodeling in skeletal muscle during aging, cachexia, and type 2 diabetes. [PDF]

Life Metab
Morena F, Viggars MR, Bohmke N, Ewachiw TE, Esser KA.   +4 more
europepmc   +1 more source

Hypercortisolism: Causes, Consequences and Clinical Significance - A Review of Pathophysiology. [PDF]

Diabetes Obes Metab
Eldib M, Fierro FE, Abad MO, Correa R.
europepmc   +1 more source

Correction to "Low Concentrations of Corticosterone Exert Stimulatory Effects on Macrophage Function in a Manner Dependent on Glucocorticoid Receptors". [PDF]

Int J Endocrinol
europepmc   +1 more source

Adenosine A_2A Receptors Control the Mis-Localization of Aquaporin-4 in Rats Subject to Repeated Restraint Stress. [PDF]

J Neurochem
Dias L, Ferreira SG, Nabais AM, Silva J, Cunha RA, Agostinho P.   +5 more
europepmc   +1 more source

Effects of catecholamines on bone and mineral metabolism in patients with pheochromocytoma and paraganglioma.

J Clin Endocrinol Metab
Alkaissi H, Pacak K, Gordon CM.
europepmc   +1 more source

Comorbidity Between Mood Disorders and Chronic Somatic Diseases, With a Focus on Cardiometabolic Disease, and Its Mechanistic Crosstalk. [PDF]

Depress Anxiety
Du H, Du G, Zhang Q, Zhao Y, Fan J, Zhou Y, Sun Z, Li C, Li W.   +8 more
europepmc   +1 more source