Results 231 to 240 of about 90,980 (312)

From Stress to Neurodegeneration: A New Look at the Pathogenesis of Parkinson's Disease. [PDF]

Biomedicines
Kazanskaya RB, Tsytsarev V, Volnova AB, Gainetdinov RR, Lopachev AV.   +4 more
europepmc   +1 more source

Transfersomes with core and surface‐loaded NF‐κB p65 siRNA for enhanced transdermal transfection and effective treatment of psoriasis

BMEMat, EarlyView.
TCPL, a transfersome with Tween 80 and PEI, enables efficient transdermal siNF‐κB delivery, resolving PEI's toxicity issue. It promotes lysosomal escape and effective transfection, silences NF‐κB, modulates immunity, and inhibits angiogenesis, alleviating psoriasis. With good biocompatibility, TCPL holds strong clinical translation potential. Schematic
Hui Xing, Yuhui Yang, Ziyi Zhao, Kai Lv, Yiran Shao, Zhi Zhang, Dong Ma   +6 more
wiley   +1 more source

Context-dependent roles of 11β-HSD1 in bone and skeletal muscle diseases. [PDF]

Am J Transl Res
Huo L, Sui W, Wang S, Zhu W, Yang Y, Zhang X, Zhang Y, Wang X.   +7 more
europepmc   +1 more source

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source

Dexamethasone-Mediated Regulation of CYP3A4 and UGTs in Human Hepatoma HuH-7 Cells. [PDF]

Fundam Clin Pharmacol
Yu H, Lee SH, Kim JH, Kim SJ, Kang HE.
europepmc   +1 more source

On the importance of including both sexes in animal studies – insights from home‐cage monitoring

Biological Reviews, EarlyView.
ABSTRACT A review of behavioural studies using home‐cage monitoring (HCM) systems revealed that over 61% of studies used only male subjects, with only 24% including both sexes, despite evidence of substantial behavioural differences between male and female animals. This bias could influence the outcomes of biomedical research.
Maša Čater, Adam Dušek, Aleksandra Bartelik, Silvia Mandillo, Elisabetta Golini, Mara Rigamonti, Rasneer Sonia Bains, Hamish Forrest, Marion Rivalan, Melissa Long, Anna Kiryk, Lars Lewejohann, Nuno Henrique Franco   +12 more
wiley   +1 more source

RU 486 blocks inhibitory effect of neonatal corticosterone administration on sertoli cell proliferation in mice. [PDF]

Sci Rep
Miyaso H, Natsuyama Y, Kawata S, Yakura T, Li ZL, Kuramasu M, Tanifuji S, Wu X, Ogawa Y, Matsuno Y, Itoh M.   +10 more
europepmc   +1 more source

From Inflammatory Bowel Disease to Cancer: Gut Microbiota–Immune Microenvironment Crosstalk and Natural Product‐Based Therapeutic Opportunities

Cancer Nexus, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD), primarily Crohn's disease and ulcerative colitis, is a chronic relapsing inflammatory disorder of the gastrointestinal tract and an important risk factor for IBD‐associated cancer. Increasing evidence suggests that gut microbiota dysbiosis, epithelial barrier dysfunction, and immune microenvironment remodeling
Xue Zhang, Chongchong Gao, Rui Jiang, Zijian Wu, Jian Bai   +4 more
wiley   +1 more source

Glucocorticoids and Neutrophil Biology: Impact on the Development of Resistance to Glucocorticoid Therapy.

Neuroimmunomodulation
Pacheco FS, da Rocha Mota RG, Pinho Jannini de Sá YA, Hogaboam CM, Castro-Faria-Neto HC, Carvalho VF.   +5 more
europepmc   +1 more source

HPA/HPG axes dysfunction: assessing the interrelations between diminished ovarian reserve and mental health. [PDF]

J Ovarian Res
Ding Z, Li X, Huang C, Wei Y, Li E, Yang Q.   +5 more
europepmc   +1 more source