Results 291 to 300 of about 2,876,830 (353)

Chaperoning of Glucocorticoid Receptors

2005
A multiprotein hsp90/hsp70-based chaperone machinery functions as a 'cradle-to-grave' system for regulating the steroid binding, trafficking and turnover of the glucocorticoid receptor (GR). In an ATP-dependent process where hsp70 and hsp90 act as essential chaperones and Hop, hsp40, and p23 act as nonessential co-chaperones, the machinery assembles ...
W B, Pratt, Y, Morishima, M, Murphy, M, Harrell   +3 more
openaire   +2 more sources

Genetics of glucocorticoid receptors

Molecular and Cellular Endocrinology, 1986
The lymphocytolytic effect of glucocorticoids has been used for isolating receptor mutants. They fall into several groups with defects either in the hormone binding domain or the DNA binding domain or with part of the receptor polypeptide missing. These truncated receptors have increased binding affinity for general DNA and are synthesized from 5 ...
openaire   +2 more sources

Selective Glucocorticoid Receptor modulators

The Journal of Steroid Biochemistry and Molecular Biology, 2010
The ancient two-faced Roman god Janus is often used as a metaphor to describe the characteristics of the Glucocorticoid Receptor (NR3C1), which exhibits both a beneficial side, that serves to halt inflammation, and a detrimental side responsible for undesirable effects. However, recent developments suggest that the Glucocorticoid Receptor has many more
openaire   +2 more sources

Maternal care, hippocampal glucocorticoid receptors, and hypothalamic-pituitary-adrenal responses to stress.

Science, 1997
Dong Liu, J. Diorio, B. Tannenbaum, Christian Caldji, D. Francis, A. (Freedman), Shakti Sharma, Debora Pearson, P. Plotsky, M. Meaney   +9 more
semanticscholar   +1 more source

The Glucocorticoid Receptor

2010
Glucocorticoids are essential for life and play critical roles in many diverse physiological processes including metabolism, development, growth, inflammation, and apoptosis. Drugs that mimic the actions of glucocorticoids are widely used to treat diseases such as cancer, inflammation, and autoimmune disorders.
Robert H. Oakley, John A. Cidlowski
openaire   +1 more source

Glucocorticoid receptors in major depression: relevance to pathophysiology and treatment.

Biological Psychiatry, 2001
C. Pariante, Andrew H. Miller
semanticscholar   +1 more source

How glucocorticoid receptors modulate the activity of other transcription factors: a scope beyond tethering.

Molecular and Cellular Endocrinology, 2013
D. Ratman, W. Vanden Berghe, L. Dejager, C. Libert, J. Tavernier, I. Beck, K. De Bosscher   +6 more
semanticscholar   +1 more source

Evolution of hormone selectivity in glucocorticoid and mineralocorticoid receptors.

Journal of Steroid Biochemistry and Molecular Biology, 2013
M. Baker, J. Funder, Stephanie R. Kattoula   +2 more
semanticscholar   +1 more source

Mineralocorticoid and glucocorticoid receptors at the neuronal membrane, regulators of nongenomic corticosteroid signalling.

Molecular and Cellular Endocrinology, 2012
Femke L. Groeneweg, H. Karst, E. D. de Kloet, M. Joëls   +3 more
semanticscholar   +1 more source

Glucocorticoid Receptor Inactivation.

1977
PhD ; Pharmacology ; University of Michigan, Horace H. Rackham School of Graduate Studies ; http://deepblue.lib.umich.edu/bitstream/2027.42/190061/2/7726327 ...
openaire   +2 more sources