Results 271 to 280 of about 90,980 (312)
Some of the next articles are maybe not open access.
Glucocorticoid Receptor Antagonists
Current Topics in Medicinal Chemistry, 2008This review covers recent progress in the discovery of selective glucocorticoid receptor (GR) antagonists. Potential therapeutic applications of selective GR antagonists are described including the pharmacological rationale and, in some cases, clinical evidence that underlies these proposed uses. Disease areas that are discussed are Cushing's syndrome,
openaire +2 more sources
CORTICOSTEROIDS | Glucocorticoid Receptors
2006Corticosteroids bind to and activate a cytoplasmic glucocorticoid receptor (GR) which exists as several isoforms derived from a single gene product by alternative splicing. The activated glucocorticoid receptor translocates into the nucleus and binds to specific response elements in the promoter regions of anti-inflammatory genes such as lipocortin-1 ...
Adcock I. M. +3 more
openaire +3 more sources
Interaction of glucocorticoid analogues with the human glucocorticoid receptor
The Journal of Steroid Biochemistry and Molecular Biology, 1992Transient co-transfection of receptor cDNA and suitable reporter genes was used to study human glucocorticoid receptor (hGR) function in a neutral mammalian cell background. A variety of natural and synthetic steroids were analyzed for their ability to activate gene expression through the hGR and to bind to extracts of cells expressing the hGR cDNA ...
T S, Berger +3 more
openaire +2 more sources
Chaperoning of Glucocorticoid Receptors
2005A multiprotein hsp90/hsp70-based chaperone machinery functions as a 'cradle-to-grave' system for regulating the steroid binding, trafficking and turnover of the glucocorticoid receptor (GR). In an ATP-dependent process where hsp70 and hsp90 act as essential chaperones and Hop, hsp40, and p23 act as nonessential co-chaperones, the machinery assembles ...
W B, Pratt +3 more
openaire +2 more sources
Glucocorticoid receptor regulation
Life Sciences, 1985Glucocorticoids, like other classes of steroid hormones, must bind to cellular receptors in order to exert their effects. Because of this central role in mediating hormone action, it is important to elucidate those factors that control receptor content.
openaire +2 more sources
2010
Glucocorticoids are essential for life and play critical roles in many diverse physiological processes including metabolism, development, growth, inflammation, and apoptosis. Drugs that mimic the actions of glucocorticoids are widely used to treat diseases such as cancer, inflammation, and autoimmune disorders.
Robert H. Oakley, John A. Cidlowski
openaire +1 more source
Glucocorticoids are essential for life and play critical roles in many diverse physiological processes including metabolism, development, growth, inflammation, and apoptosis. Drugs that mimic the actions of glucocorticoids are widely used to treat diseases such as cancer, inflammation, and autoimmune disorders.
Robert H. Oakley, John A. Cidlowski
openaire +1 more source
Combined glucocorticoid resistance and hyperlactatemia contributes to lethal shock in sepsis
Cell Metabolism, 2021Jolien Vandewalle +2 more
exaly
A macrophage-hepatocyte glucocorticoid receptor axis coordinates fasting ketogenesis
Cell Metabolism, 2022Anne Loft +2 more
exaly
2011
Stress represents a significant problem for Western societies inducing costs as high as 3-4 % of the European gross national products, a burden that is continually increasing (WHO Briefing, EUR/04/5047810/B6). The classical stress response system is the hypothalamic-pituitary-adrenal (HPA) axis which acts to restore homeostasis after disturbances.
openaire +1 more source
Stress represents a significant problem for Western societies inducing costs as high as 3-4 % of the European gross national products, a burden that is continually increasing (WHO Briefing, EUR/04/5047810/B6). The classical stress response system is the hypothalamic-pituitary-adrenal (HPA) axis which acts to restore homeostasis after disturbances.
openaire +1 more source