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Glucocorticoid Receptor Antagonists
Current Topics in Medicinal Chemistry, 2008This review covers recent progress in the discovery of selective glucocorticoid receptor (GR) antagonists. Potential therapeutic applications of selective GR antagonists are described including the pharmacological rationale and, in some cases, clinical evidence that underlies these proposed uses. Disease areas that are discussed are Cushing's syndrome,
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Interaction of glucocorticoid analogues with the human glucocorticoid receptor
The Journal of Steroid Biochemistry and Molecular Biology, 1992Transient co-transfection of receptor cDNA and suitable reporter genes was used to study human glucocorticoid receptor (hGR) function in a neutral mammalian cell background. A variety of natural and synthetic steroids were analyzed for their ability to activate gene expression through the hGR and to bind to extracts of cells expressing the hGR cDNA ...
T S, Berger +3 more
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Impact of Glucocorticoid Receptor Polymorphisms on Glucocorticoid Action
2019Glucocorticoids, with cortisol being the foremost player, comprehend a class of steroid hormones responsible for a wide range of actions. An important regulator in the glucocorticoid cascade is the glucocorticoid receptor. After binding of the glucocorticoid, this receptor can both up- and downregulate certain target genes but can also directly ...
Savas, Mesut, Van Rossum, Elisabeth F.C.
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2010
Glucocorticoids are essential for life and play critical roles in many diverse physiological processes including metabolism, development, growth, inflammation, and apoptosis. Drugs that mimic the actions of glucocorticoids are widely used to treat diseases such as cancer, inflammation, and autoimmune disorders.
Robert H. Oakley, John A. Cidlowski
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Glucocorticoids are essential for life and play critical roles in many diverse physiological processes including metabolism, development, growth, inflammation, and apoptosis. Drugs that mimic the actions of glucocorticoids are widely used to treat diseases such as cancer, inflammation, and autoimmune disorders.
Robert H. Oakley, John A. Cidlowski
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Combined glucocorticoid resistance and hyperlactatemia contributes to lethal shock in sepsis
Cell Metabolism, 2021Karolien de Bosscher +2 more
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Polymorphisms of the Glucocorticoid Receptor Gene and Major Depression
Biological Psychiatry, 2006Marcus Ising +2 more
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Glucocorticoid receptor signaling in health and disease
Trends in Pharmacological Sciences, 2013John Cidlowski, Mahita Kadmiel
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