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Mammalian ionotropic glutamate receptors

Current Opinion in Neurobiology, 1993
Exciting new milestones in glutamate receptor (GluR) channel research include the following: the cloning of N-methyl-D-aspartate (NMDA) receptors; delineation of molecular determinants for ion flow through glutamate-gated channels; the discovery that Ca2+ permeability of non-NMDA receptor channels is determined by RNA editing; the construction of ...
Wisden, W., Seeburg, P.
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Glutamate and Glutamate Receptors in the Vertebrate Retina

2023
Book chapter published in: Kolb, H., Fernandez, E., Nelson, R., Webvision: The Organization of the Retina and Visual System [Internet].
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Molecular biology of glutamate receptors

Progress in Neurobiology, 1994
The ligand-gated receptors for L-glutamate play a central role in acute neuronal degeneration. Recently cDNAs have been isolated for subunits of several glutamate receptor subtypes. By sequence homology all these subunits clearly belong to one large gene family.
Schöpfer, R.   +12 more
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The Identity of Plant Glutamate Receptors

Science, 2001
Ion channels are important in the perception and transduction of environmental signals in essentially all organisms. Plants are no exception. Completion of the Arabidopsis genome-sequencing project has revealed that among the 600 Arabidopsis genes predicted to encode membrane transport proteins ...
Lacombe, B   +13 more
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Glutamate receptor channel signatures

Trends in Pharmacological Sciences, 2001
Genes encoding glutamate receptor channel subunits were identified in genomes from Drosophila melanogaster and Caenorhabditis elegans by homology search with amino acid sequences that participate in the conserved channel pore. The predicted sequences of the putative glutamate receptor subunits revealed a distinct channel pore signature for each ...
Sprengel, R.   +5 more
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Glutamate Receptors and Glutamate Corticofugal Pathways

1986
Although the neurochemical anatomy of many pathways in human brain has been studied, little attention has been paid to the human pyramidal system. This pathway is very important for voluntary motor control in vertebrates, and pyramidal tract pathology leads to hemiparesis or hemiplegia in primates and man (Phillips and Porter, 1977).
Anne B. Young   +3 more
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Glutamate Receptors in Taste Receptor Cells

2007
Glutamate plays a double role in the physiology of TRCs. As a free-occurring component of some foodstuff, glutamate is detected by TRCs and conveys information about the presence of protein-rich source. As a substance released by TRC and/or nerve endings, it is involved in cell-to-cell communication at chemical synapses in taste organs.
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Glutamate Receptors in Pollen

Science Signaling, 2011
Amino acid modulation of Ca 2+ signaling guides growth of plant pollen tubes.
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Glutamate receptors

2000
Publisher Summary Glutamate receptors come in two types: ionotropic and metabotropic. The ionotropic receptors are ligand-gated ion channels. Traditionally, ionotropic glutamate receptors have been classified according to their preferred agonists into: AMPA (a-amino-3- hydroxy-5-methyl-4-isoxazoleproprionate), kainate and NMDA (N-methyl- D-aspartate ...
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Glutamate Receptor Antagonists

Headache Currents, 2004
GLUR5 Antagonists as Novel Migraine TherapiesBACKGROUND: L‐glutamate activates neurons in the trigeminal nucleus caudalis (TNC). Furthermore, non‐NMDA ionotropic glutamate receptors such as GluR5 are expressed in rat trigeminal ganglion (TG), and GluR5 receptors play an important role in central sensitization (CS).
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